Tracing the Evolutionary Dynamics and the Transcriptional Partitioning of Terpene Synthase Gene Family in Coffea arabica and Its Diploid Progenitors [0.03%]
Coffea arabica及其二倍体祖先中萜类合酶基因家族的转录分隔及进化动态分析
Makarim Elfadil M Osman,Mohanad A Ibrahim,Rieham Sallah H Osman et al.
Makarim Elfadil M Osman et al.
Terpenes represent a diverse class of plant secondary metabolites that play important roles in development, ecological interactions, and aroma, and are synthesized by the terpene synthase (TPS) gene family. To investigate the evolutionary h...
Hidden in the Pangenome? Machine Learning-Driven Discovery of Antimicrobial Potential in Corynebacterium glutamicum [0.03%]
隐藏在泛基因组中？机器学习驱动的发现天冬氨酸棒杆菌抗菌潜能
Sk Injamamul Islam,Khandker Shahed,Mst Mahmuda Parvin et al.
Sk Injamamul Islam et al.
Antimicrobial resistance poses an increasing global challenge, driving the urgent need for alternative strategies to identify novel therapeutic agents. Microbial natural products encoded by biosynthetic gene clusters (BGCs) remain among the...
In silico Design and Analysis of Engineered Proteins Containing Multi-Epitope and Immunodominant Domains Derived From Rickettsia prowazekii A ntigens [0.03%]
基于康氏立克次体抗原的多表位与优势B细胞表位工程蛋白质的计算机设计和分析
Massrehaw Assnakew Abebe,Desye Melese Sisay,Abebaw Fekadu et al.
Massrehaw Assnakew Abebe et al.
Epidemic louse-borne typhus caused by Rickettsia prowazekii and transmitted by the human body louse, remains a major public health threat in many developing regions. Historical records indicate that outbreaks have resulted in up to million ...
Chemoinformatic Approaches to Identify Bioactive Inhibitors Against Type I Dehydroquinase (DHQ1) Enzyme of Typhoidal Salmonella [0.03%]
用于鉴定伤寒沙门氏菌I型脱氢酶(DHQ1)的生物活性抑制剂的化学信息学方法
Aqsa Ashfaq,Safah Mariyam,Ubair Aziz et al.
Aqsa Ashfaq et al.
The incidence of antibiotic resistance is critically jeopardizing the public health of the new millennium, affecting both clinical and therapeutic outcomes. Typhoid perforation in low- and middle-income countries (LMICs) is mostly caused by...
Web-Based Graphical User Interface Design Integrating MATLAB Server for the Mathematical Model of Human Cardiovascular-Respiratory System [0.03%]
基于MATLAB服务器的人体心血管呼吸系统数学模型的网页界面设计
Jean Marie Ntaganda,Solange Mukeshimana,Marcel Ndengo et al.
Jean Marie Ntaganda et al.
A mathematical model of the human cardiovascular-respiratory system is proposed in several MATLAB graphical user interface (GUI) designs. However, it is observed that the latter are not web-based designed, making it hard for users to use th...
Listeria Genome Identification Using DNABERT Embedding With LightGBM and SHAP-Based Explainable Classification [0.03%]
基于DNABERT嵌入和LightGBM以及SHAP可解释分类的李斯特菌基因组识别
Sajeev Ram Arumugam,Ananth J P,Sankar Ganesh Karuppasamy et al.
Sajeev Ram Arumugam et al.
Prompt and accurate identification of Listeria monocytogenes at the whole-genome level is essential for food safety surveillance and outbreak prevention, yet existing culture-based, PCR, and next-generation sequencing (NGS) workflows are ei...
A Novel Bioinformatics Pipeline and a Machine-Learning Approach for Antimicrobial Resistance Phenotypic Prediction [0.03%]
一种预测抗菌药物敏感性的生物信息学新流程及机器学习方法
Owen Visser,Victor Agboli,Somnath Datta
Owen Visser
Overuse of antimicrobial drugs is known to cause an increase in bacterial resistance among surviving pathogens, reducing the effectiveness of future treatments. Publicly available sequencing collections, such as the National Center for Biot...
Integrated Computational Profiling Links Position-specific O-Methylation to Spontaneous Complexation and Improved Binding in Flavonoid-HER2 Systems [0.03%]
集成计算定位甲基化黄酮类化合物与HER2系统的自发螯合及结合改善作用的关系
Precious A Akinnusi,Samuel O Olubode,David N A Okai et al.
Precious A Akinnusi et al.
Human epidermal growth factor receptor 2-positive (HER2+) breast cancer is characterized by amplification and overexpression of HER2. This study used a computational workflow to identify O-methylated flavonoids with favorable binding to the...
Computational Characterization of Nabilone-Induced Disruption of the CB2-HER2 Receptor Complex in HER2+ Breast Cancer [0.03%]
纳博灵诱导的CB2-HER2受体复合物在乳腺癌中的干扰的计算表征
Abbou Hanane,Zegrari Razana,Gaouzi Zainab et al.
Abbou Hanane et al.
Human epidermal growth factor receptor 2-positive (HER2+) breast cancer, accounting for 15% to 20% of cases, is often resistant to treatment. Delta-9-tetrahydrocannabinol (THC) disrupts HER2-cannabinoid receptor (2CB2) receptor complexes an...
Integrated Analysis of lncRNA-miRNA-mRNA ceRNA Network and Identification of Hub lncRNAs in Molecular Subtypes of Gastric Cancer as Potential Prognostic Indicators [0.03%]
胃癌分子亚型的长链非编码RNA-微小RNA-信使RNA竞争性内源RNA网络综合分析及潜在预后标志物核心长链非编码RNA识别
Seyed Navid Goftari,Ahmad Reza Bahrami,Maryam M Matin
Seyed Navid Goftari
Background: Gastric cancer (GC) is the fourth most common cause of death among cancers in the world, and the most prevalent type of GC is adenocarcinoma. The Cancer Genome Atlas (TCGA) project introduced 4 molecular subty...