Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intravenous Administration JMKX003142 in Chinese Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Single, and Multiple Ascending Dose Phase I Clinical Trial [0.03%]
JMKX003142静脉给药在中国健康受试者中的安全性、耐受性、药代动力学和药效学：一项随机、双盲、安慰剂对照及单次/多次递增剂量I期临床试验
Cheng Cui,Jixiang Zhu,Zhiping Liu et al.
Cheng Cui et al.
Purpose: This study is the first-in-human study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) profiles of single ascending doses (SAD) and multiple ascending doses (MAD) of JMKX003...
Charting the Current Landscape and Future Prospects of Cancer Therapy-Related Cardiovascular Toxicity in Cancer Survivors: From Bench to Bedside [0.03%]
从实验室到临床：绘制癌症幸存者癌症治疗相关心血管毒性的当前格局和未来前景
Shiyi Tao,Lintong Yu,Lanxin Zhang et al.
Shiyi Tao et al.
Cardio-oncology represents an emerging interdisciplinary discipline focusing on optimizing oncologic efficacy while mitigating treatment-related cardiovascular complications. The advent of novel anticancer agents such as targeted therapies,...
Multi-Technology Empowers Dissolving Microneedles: A Novel Strategy in Rheumatoid Arthritis [0.03%]
多技术赋能溶解型微针：类风湿性关节炎的新策略
Tian-Tian Wei,Yu-Meng Song,Bing-Tao Zhai et al.
Tian-Tian Wei et al.
Rheumatoid arthritis (RA) is a systemic autoimmune disease associated with chronic inflammation. Current clinical management is confronted with multiple challenges, such as suboptimal drug bioavailability, insufficient joint targeting, and ...
Advances in Targeting the AGEs-RAGE Pathway for the Treatment of Diabetic Kidney Disease [0.03%]
靶向晚期糖基化终产物受体通路治疗糖尿病肾病新进展
Xiudan Li,Jingsong Mei
Xiudan Li
Diabetic kidney disease (DKD) represents the most severe microvascular complication of diabetes and is the leading cause of end-stage renal disease globally. Its pathogenesis is complex, and current treatments have limitations. Advanced gly...
Compatibility and Stability Study of Butorphanol, Nicardipine, Urapidil, and Tirofiban During Multidrug Simultaneous Infusion [0.03%]
布托啡诺、尼卡地平、乌拉地尔和替罗菲班联合输注的配伍与稳定性研究
Xiaoyu Zhao,Liting Zhang,Siqi Yu et al.
Xiaoyu Zhao et al.
Purpose: This study aimed to assess the physicochemical stability and compatibility of butorphanol tartrate, nicardipine hydrochloride, urapidil, and tirofiban hydrochloride to support safe infusion practices in the ICU. ...
Therapeutic Potential of Cannabinoids in Attenuating Amiodarone-Induced Pulmonary Fibrosis: An in vivo Experimental Study in Wistar Rats [0.03%]
大鼠体内实验研究：大麻素减轻胺碘酮所致肺纤维化的治疗潜力
Riyadh S Almalki
Riyadh S Almalki
Introduction: Amiodarone (AMIO) is one of the most prescribed antiarrhythmic medications and is commonly used to treat atrial and ventricular fibrillations. A notable adverse effect of AMIO is pulmonary fibrosis. Cannabin...
Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Intravenous Vancomycin in Intracranial Hemorrhage Patients with External Ventricular Drains: Implications for Dosing and Therapeutic Drug Monitoring [0.03%]
外引流颅内出血患者静脉注射万古霉素的群体药代动力学及脑脊液穿透：关于给药和治疗药物监测的启示
Yu-Ju Tseng,Liang Juan,Chien-Chih Wu et al.
Yu-Ju Tseng et al.
Purpose: Vancomycin is frequently used to treat central nervous system (CNS) infections, yet its cerebrospinal fluid (CSF) penetration remains poorly characterized in patients with intracranial hemorrhage (ICH) requiring ...
Observational Study
Drug design, development and therapy. 2026 Mar 2:20:574548. DOI:10.2147/DDDT.S574548 2026
Gut-Derived Hippuric Acid Alleviates Hepatic Lipid Metabolism via UGDH/FOXK1/CD36 Axis in Obese Mice [0.03%]
肠道衍生的水杨酸通过UGDH/FOXK1/CD36轴改善肥胖小鼠肝脂代谢
Shuai Chen,Jiaming Xue,Yuancheng Shao et al.
Shuai Chen et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease globally, creating an urgent need to elucidate its pathogenesis and develop effective therapeutic ...
Anti-Vascular Endothelial Growth Factor Combined with Dexamethasone Implant Therapy for Macular Edema: A Randomized Controlled Trial [0.03%]
抗血管内皮生长因子联合地塞米松植入治疗黄斑水肿的疗效：一项随机对照试验
Yunxi Ma,Junwen Wang,Mingzhu Yuan et al.
Yunxi Ma et al.
Purpose: To compare the efficacy and safety of intravitreal conbercept monotherapy versus conbercept combined with dexamethasone implant in eyes with macular edema (ME). ...
Randomized Controlled Trial
Drug design, development and therapy. 2026 Mar 3:20:587166. DOI:10.2147/DDDT.S587166 2026
Coenzyme Q10 Impact on Ovarian Reserve Measures and the Intra-Cytoplasmic Sperm Injection (ICSI) Outcomes in Women with Poor Ovarian Response: A Randomized Controlled Study [0.03%]
辅酶Q10对卵巢反应不良患者卵巢储备指标及卵胞浆内单精子显微注射(ICSI)结局的影响：一项随机对照研究
Mona A Abdelrahman,Mayar Gamal,Sara A Salem et al.
Mona A Abdelrahman et al.
Background: Poor ovarian response (POR) is a serious problem that decreases the effectiveness of conventional ovarian stimulation. Its concern is elevated production of reactive oxygen species, causing DNA destruction and...