Tideglusib-Preactivated Osteoblasts Encapsulated in Ceramic Particle-Reinforced GelMA Hydrogel for Enhanced Critical-Size Bone Defect Regeneration [0.03%]
预激活成骨细胞封装于陶瓷颗粒增强明胶甲基丙烯酸酯水凝胶中用于大尺寸骨缺损修复
Keqin Cao,Hongxu Shang,Yexin Li et al.
Keqin Cao et al.
Purpose: Critical-size bone defects remain a clinical challenge due to limited intrinsic bone regeneration. This study developed a composite scaffold composed of osteoinductive biphasic calcium phosphate (BCP) ceramic par...
Wise as a Serpent and Gentle as a Dove: Pharmacological Targeting of NRF2/KEAP1 Pathway from Treasure Trove of Mother Nature [0.03%]
老练如蛇，温顺如鸽：从自然界宝库中靶向NRF2/KEAP1通路的药物学研究
Ammad Ahmad Farooqi,Sabit Zhussupov,Assiya Turgambayeva et al.
Ammad Ahmad Farooqi et al.
Discovery of NRF2 in 1994 was once assumed simplistic and classical but the following years witnessed phenomenal breakthroughs that led to a rapid increase in the components of complex molecular web. Emerging evidence has enabled us to deve...
Probiotics in Combination with C16 Peptide and Angiopoietin-1 Synergistically Ameliorate Multiple Sclerosis in Mice [0.03%]
益生元与C16肽和血管生成素-1联合协同改善小鼠多发性硬化症
Qiang Li,Yi Zhao,Lu Bai et al.
Qiang Li et al.
Background: Multiple sclerosis (MS) is a debilitating autoimmune disease of the central nervous system (CNS), characterized by demyelination, axonal loss, and neuronal injury. At present, effective treatment options remai...
Safety and Efficacy of Oliceridine Combined with Propofol for Painless Gastroscopy: A Single-Center, Randomized, Parallel Controlled Clinical Trial [0.03%]
奥曲肽联合丙泊酚无痛胃镜的镇痛安全性和有效性研究：一项单中心随机平行对照临床试验
Xuping Hu,Chunyuan Yang,Jun Li et al.
Xuping Hu et al.
Purpose: To explore the safety and efficacy of the novel G protein-biased μ-opioid receptor agonist oliceridine for painless gastroscopy. Methods: ...
Methodological Concerns Regarding ED95 Estimation and Outcome Interpretation in the Remimazolam Dose-Finding Study for HIFU Ablation [Letter] [0.03%]
关于瑞玛唑仑用于HIFU消融剂量寻找研究中ED95估算和结果解读的方法学问题[信函]
Shan Yu,Jie Meng,Jingdong Li
Shan Yu
Targeting Bruton's Tyrosine Kinase (BTK) in Autoimmunity: Achievements, Opportunities and Challenges [0.03%]
靶向布鲁顿酪氨酸激酶(BTK)治疗自身免疫病：现状、机遇与挑战
Sebastian Torke,Sarah Dybowski,Martin S Weber
Sebastian Torke
The selective inhibition of Bruton's tyrosine kinase (BTK) has emerged as a promising therapeutic strategy for autoimmune diseases by targeting key signaling pathways in both adaptive and innate immune cells. Initially developed for B cell ...
Effect of Oliceridine on the Acute Postoperative Pain Management After Elective Cesarean Delivery: A Randomized Non-Inferiority Trial [0.03%]
一项关于口服利克林啶对择期剖宫产术后急性疼痛管理影响的随机非劣效性试验
Jing Jiang,Guanghua Yuan,Yuhui Shi et al.
Jing Jiang et al.
Purpose: Effective postoperative analgesia following cesarean delivery is crucial for maternal recovery. Sufentanil, commonly administered via patient-controlled intravenous analgesia (PCIA), is associated with dose-depen...
The Effect of Esketamine on Peripheral Vascular Resistance in Elderly Patients During Anesthesia Induction: A Single-Center, Double-Blind, Prospective, Randomized Controlled Study [0.03%]
氯胺酮对老年患者麻醉诱导期外周血管阻力的影响：单中心、双盲、前瞻性随机对照试验
Jingjing Li,Yu Gao,Kailun Jing et al.
Jingjing Li et al.
Purpose: To investigate the effect of esketamine on peripheral vascular resistance in elderly patients during anesthesia induction. Patients and methods: ...
Real-World Comparative Weight Loss of GLP-1 Receptor Agonists in the All of Us Research Program: A Retrospective Cohort Study [0.03%]
在美国全民医学研究计划中的GLP-1受体激动剂真实世界体重比较观察性队列研究
Inyoung Hwang,Sang Won Lee,Yun Kim
Inyoung Hwang
Purpose: To assess the real-world associations of five glucagon-like peptide-1 receptor agonists (GLP-1RAs) with weight loss in a diverse US population of adults with obesity, with and without type 2 diabetes, and whether...
Comparative Study
Drug design, development and therapy. 2026 Jul 14:20:604247. DOI:10.2147/DDDT.S604247 2026
Obinutuzumab as a Rescue and Maintenance Strategy in Children with Difficult-to-Treat Nephrotic Syndrome After Rituximab-Based Treatment Failure or Intolerance: A Preliminary Single-Center Real-World Retrospective Study [0.03%]
奥滨尤单抗治疗利妥昔单抗治疗失败或不耐受的难治性儿童肾病综合征的有效性和安全性：一项初步回顾性单中心研究
Haoqiong Sun,Ling Guo,Panpan Shao et al.
Haoqiong Sun et al.
Purpose: This preliminary study aimed to describe the effectiveness and safety of obinutuzumab as a rescue and maintenance anti-CD20 strategy in children with difficult-to-treat nephrotic syndrome after failure or intoler...