Semaglutide Inhibits Osteoblast Ferroptosis Induced by Diabetic Periodontitis via Modulating the Wnt5a/Ror2/p38 MAPK Signaling Pathway [0.03%]
司美格鲁肽通过调节Wnt5a/Ror2/p38MAPK信号通路抑制糖尿病牙周炎诱导的成骨细胞铁死亡
Zhen Zhang,Delong Niu,Wenjie Qiu et al.
Zhen Zhang et al.
Background: Type 2 diabetes mellitus (T2DM) is a major risk factor for periodontitis, often leading to exacerbated alveolar bone loss. Ferroptosis, an iron-dependent regulated cell death pathway, contributes to osteoblast...
Methylene Blue for Prevention of Perioperative Neurocognitive Disorders: Mechanisms and Recent Clinical Evidence [0.03%]
亚甲蓝预防围术期神经认知障碍的机制和最新临床证据
Yu Wu,Jinbao Wang,Xiaojian Wan
Yu Wu
Background: Perioperative neurocognitive disorders (PND), encompassing postoperative delirium (POD) and delayed neurocognitive recovery (dNCR), affect 15-40% of elderly surgical patients and are associated with accelerate...
Clarifying Baseline Cognitive Eligibility and Cross-Scale Follow-Up in a Randomized Trial of Remimazolam Tosylate for Laparoscopic Surgery [Response To Letter] [0.03%]
瑞莫马唑托磺酸盐用于腹腔镜手术的随机试验的认知基线符合标准和跨规模随访的澄清答复信
Jingya Liu,Mengyu Li,Huimin Wang et al.
Jingya Liu et al.
Efficacy and Safety of Ciprofol versus Propofol for Tracheal Intubation in Pediatric Patients Undergoing Laparoscopic Hernia Repair: An Assessor-Blinded Randomised Controlled Trial [0.03%]
小儿腹腔镜疝气修复气管插管中使用希捷倍乐较普利姆的疗效及安全性：研究者盲法随机对照试验
Jieze Pan,Tianhao Zhong,Yiwen Lv et al.
Jieze Pan et al.
Background: Ciprofol, a novel GABAA receptor agonist, might be an alternative for pediatric anesthesia. This study aimed to determine the ED95 of ciprofol, and compare its efficacy and safety with propofol for tracheal in...
Randomized Controlled Trial
Drug design, development and therapy. 2026 May 22:20:602666. DOI:10.2147/DDDT.S602666 2026
Adequate Sedation or Deep Sedation? Interpreting Sex-Neutral Dexmedetomidine ED50 Findings in Upper Limb Surgery [Letter] [0.03%]
足够的镇静还是深度镇静？上肢手术中性别无关的右美托咪定ED50结果解读[信函]
Yuanyuan Li,Gen Li,Bin Zhang
Yuanyuan Li
An LC-MS/MS Method for Simultaneous Determination of Almonertinib and Atorvastatin: Evaluating Their Drug-Drug Interactions in Rat [0.03%]
大鼠体内阿洛莫芬替尼和阿托伐他汀的药物相互作用评价及其LC-MS/MS测定方法
Huanchen Li,Hongkun Wu,Shouhong Gao et al.
Huanchen Li et al.
Objective: Atorvastatin is frequently used in combination with almonertinib in lung cancer patients who present with comorbid dyslipidemia. Both drugs are metabolized by CYP3A4, potentially leading to drug-drug interactio...
Single-Injection Liposomal Bupivacaine Adductor Canal Block for Pain Control and Recovery After Total Knee Arthroplasty: A Randomized Controlled Double‑Blinded Study [0.03%]
单剂量布比卡因脂质体 adductor 神经丛阻滞用于全膝关节置换术后镇痛和加速康复：一项随机双盲研究
Jiajun Wen,Haobin Peng,Ying Jiang et al.
Jiajun Wen et al.
Objective: The efficacy of the adductor canal block (ACB) in multimodal analgesia following total knee arthroplasty (TKA) remains controversial. This study investigates the effects of local anesthetics single-injection AC...
Randomized Controlled Trial
Drug design, development and therapy. 2026 May 20:20:587861. DOI:10.2147/DDDT.S587861 2026
Pharmacokinetics, Safety and Tolerability of HPP737, a Novel PDE4 Inhibitor, in Healthy Chinese Participants: Phase I Study [0.03%]
HPP737（一种新型磷酸二酯酶-4抑制剂）在中国受试者中的药代动力学、安全性和耐受性：I期研究
Lijun Ye,Lin Wang,Xuexia Tao et al.
Lijun Ye et al.
Background and objective: HPP737, a novel phosphodiesterase 4 (PDE4) inhibitor, was designed to treat chronic obstructive pulmonary disease (COPD). This study aimed to evaluate its pharmacokinetics, safety and tolerabilit...
The ED90 of Oliceridine for Tracheal Intubation in Children: A Biased-Coin Up-and-Down Parallel Dose-Finding Study [0.03%]
用于儿童气管插管的Oliceridine的ED90剂量：平行剂量寻找研究（小偏 coin 上下随机法）
Liqun Cheng,Jing Jiang,Mengqi Li et al.
Liqun Cheng et al.
Background: Oliceridine as a novel biased μ-opioid receptors agonist that selectively activates G protein-mediated signaling, has been associated with a lower incidence of opioid-related adverse events (ORAEs). However, ...
Randomized Controlled Trial
Drug design, development and therapy. 2026 May 19:20:601178. DOI:10.2147/DDDT.S601178 2026
Alfentanil May Reduce Early Postoperative Nausea and Vomiting in Moderate-to-High Risk Patients Undergoing Gastrointestinal Endoscopy: A Prospective Double-Blind Randomized Study [0.03%]
Alfentanيل可能减少中高风险胃肠内镜患者的早期术后恶心和呕吐：一项前瞻性双盲随机研究
Xiao-Yu Gu,Jin-Feng Cao,Xin-Yang Zhang et al.
Xiao-Yu Gu et al.
Objective: This trial aimed to compare the effects of alfentanil and sufentanil on postoperative nausea and vomiting (PONV) in patients at moderate-to-high risk undergoing sedated gastrointestinal endoscopy. ...
Randomized Controlled Trial
Drug design, development and therapy. 2026 May 20:20:598415. DOI:10.2147/DDDT.S598415 2026