Health Technology Assessment of Oxazolidinones for MRSA-Associated Complicated Skin and Soft Tissue Infections [0.03%]
奥沙唑喃治疗耐甲氧西林金黄色葡萄球菌复杂性皮肤和软组织感染的卫生技术评估
Yucheng Zhao,Baisen Huang,Zunchang Yang et al.
Yucheng Zhao et al.
Purpose: This study aims to provide a reference for the introduction and utilization of oxazolidinone drugs in medical institutions, based on the authoritative Chinese guideline, Rapid Guideline for Drug Evaluation and Se...
Targeting Esophageal Cancer: Promising Drugs for the Clinical Landscape and Key Knowledge Gaps [0.03%]
瞄准食管癌：临床领域中前景良好的药物及关键知识空白点
Terzungwe Akumaga,Haeseong Park,A Craig Lockhart et al.
Terzungwe Akumaga et al.
Esophageal cancer remains a major global health burden, ranking seventh in cancer-related mortality. The prognosis is poor with five-year survival rates below 5% for metastatic disease. Tumor heterogeneity and the development of treatment r...
Solidification of SNEDDS Using Mesoporous Carriers (2020-2025): A Review of Design, Biopharmaceutical Enhancement, and Therapeutic Impact [0.03%]
利用介孔载体固化SNEDDS（2020-2025）：设计、生物药剂学增强和治疗影响综述
Sani Ega Priani,Adilah Nurhaliza,Anis Yohana Chaerunisaa et al.
Sani Ega Priani et al.
Self-nanoemulsifying drug delivery systems (SNEDDS) have been widely developed as a practical approach to enhance the bioavailability of poorly water-soluble drugs through nanoscale emulsification. To improve the stability and practicality ...
Impact of High Tacrolimus Exposure on Graft Function and Development of a Prediction Model in Kidney Transplant Recipients: A Single-Center Retrospective Cohort Study [0.03%]
高他克莫司暴露对肾移植受者移植物功能的影响及其预测模型的建立：单中心回顾性队列研究
Wenyu Yang,Renfei Xia,Peijin Zhao et al.
Wenyu Yang et al.
Purpose: To evaluate the association between early supratherapeutic tacrolimus exposure (trough concentration >20 ng/mL within the first postoperative week) and graft outcomes in kidney transplant recipients, and to devel...
Drug Repurposing as an Effective Drug Discovery Strategy: A Critical Review [0.03%]
药物再利用作为有效的药物发现策略：批判性综述
Abdulaziz H Al Khzem,Saad M Wali
Abdulaziz H Al Khzem
Drug repurposing, or repositioning, has emerged as a pivotal strategy in pharmaceutical research, offering a promising approach to uncover new therapeutic uses for existing drugs. While traditional de novo drug discovery typically requires ...
Therapeutic Targeting of Signaling Pathways in Abdominal Aortic Aneurysm: From Pathogenesis to Precision Medicine [0.03%]
腹主动脉瘤信号通路的治疗靶向：从发病机制到精准医学
Imran Ibrahim Shaikh,Shekhar Singh,Yuling Feng et al.
Imran Ibrahim Shaikh et al.
Abdominal aortic aneurysms (AAAs) are life-threatening cardiovascular disorders with limited treatment options, largely due to an incomplete understanding of their molecular and cellular pathogenesis. A comprehensive elucidation of the mech...
Copper-Induced Cell Death in Renal Diseases: Molecular Mechanisms and Therapeutic Implications [0.03%]
铜引起的肾病细胞死亡：分子机制和治疗意义
Daoyuan Lv,Yafen Yu
Daoyuan Lv
Copper dyshomeostasis and the resulting induction of cuproptosis, a novel regulated cell death pathway driven by mitochondrial copper overload, play a critical role in renal pathophysiology. Cuproptosis is characterized by FDX1-mediated cop...
A Comparison of the Effect of Remimazolam and Midazolam on Recovery and Preserved Memory Function for Patients with Dental Extraction Anxiety [0.03%]
瑞米唑仑与咪达唑仑对拔牙焦虑患者苏醒及记忆功能影响的比较
Quan Jing,Weijia Wang,Limeng Wu et al.
Quan Jing et al.
Purpose: Remimazolam is an ultrashort-acting benzodiazepine, which has been indicated to be effective in endoscopic surgery and general anaesthesia. Research on its use in outpatient dental procedures remains limited. Thi...
Sugammadex versus Neostigmine Reversal After Thoracoscopic Thymectomy in Myasthenia Gravis: A Multicenter, Randomized Controlled Trial [0.03%]
电视胸腔镜下重症肌无力胸腺切除术后舒更葡糖与新斯的明拮抗效果的多中心随机对照试验
Chunhua Hu,Shijiang Liu,Chunhua Xi et al.
Chunhua Hu et al.
Purpose: Rapid and complete reversal of residual neuromuscular blockade (rNMB) is essential for safe postoperative recovery in patients with myasthenia gravis (MG) undergoing video-assisted thoracoscopic (VATS) thymectomy...
Protective Effect of Dexmedetomidine Combined with Butorphanol on Perioperative Pulmonary Function in Patients Undergoing Laparoscopic Colorectal Cancer Resection: A Randomized, Double-Blind, 2 * 2 Factorial-Controlled Trial [0.03%]
右美托咪啶联合布托啡诺对结直肠癌腹腔镜手术患者围术期肺功能保护的疗效研究：一项随机、双盲、2×2因子对照试验
Huan Li,Guangyue Zhou,Haoxuan Chen et al.
Huan Li et al.
Background: Perioperative lung injury significantly affects the outcome of abdominal surgery. Research has shown that both dexmedetomidine and butorphanol can provide some perioperative lung protection. This study evaluat...