Indication Expansion Dynamics and Trial Characteristics of Novel Multi-Indication Anti-Cancer Drugs in China (2000-2024): A Cross-Sectional Study [0.03%]
Xiaoyi Chen,Huan Li,Shunlong Ou et al.
Xiaoyi Chen et al.
Purpose: To perform a cross-sectional analysis of the indication expansion trends and pivotal trial features of novel multi-indication anti-cancer drugs approved in China from 2000 to 2024. ...
Development, Characterization, and Clinical Evaluation of a 6% Nitroglycerin-Aloe Vera Transdermal Gel for Stable Angina Management [0.03%]
Muhammad Omer Iqbal,Kashaf Khan Anjum Bhutta,Imran Ahmad Khan et al.
Muhammad Omer Iqbal et al.
Purpose: This study aimed to develop, characterize, and clinically evaluate a novel 6% nitroglycerin (NTG) Aloe vera gel formulation as a transdermal alternative to conventional sublingual NTG therapy in patients with sta...
Ahmad Nazrun Shuid,Siti Farah Alwani Mohd Nawi,Siti Norsyafika Kamarudin et al.
Ahmad Nazrun Shuid et al.
The increasing prevalence of antibiotic-resistant bacteria has intensified the search for alternative antimicrobial agents, with plant-derived extracts emerging as promising candidates. The Acmella genus, known for its rich array of bioacti...
Dexmedetomidine Use and Intraoperative Bradycardia During Radiofrequency Rhizotomy for Trigeminal Neuralgia: A Retrospective Observational Study [0.03%]
Chen-Hsi Tang,Shao-Chun Wu,Chung-Ming Yu et al.
Chen-Hsi Tang et al.
Purpose: Intraoperative bradycardia is a recognized complication during radiofrequency (RF) rhizotomy for trigeminal neuralgia, primarily related to the trigeminal-cardiac reflex. Dexmedetomidine is commonly used for its ...
Observational Study
Drug design, development and therapy. 2026 Mar 7:20:592347. DOI:10.2147/DDDT.S592347 2026
Traditional Chinese Medicine and Ferroptosis in Alzheimer's Disease: A Potential Therapeutic Approach [0.03%]
Annan Liu,Liping Xing,Jianhui Li et al.
Annan Liu et al.
Alzheimer's disease (AD) represents a prevalent neurodegenerative disorder associated with considerable morbidity and mortality. Currently, no therapeutic agents exist that can achieve a fundamental reversal or complete cure for this condit...
Huike Ma,Xiawei Zhang,Ruonan Li et al.
Huike Ma et al.
Hypericin, a polycyclic quinone derived from *Hypericum perforatum* (St. John's Wort), has gained attention for its broad pharmacological activities, including anti-inflammatory, antimicrobial, and antitumor effects. It modulates key signal...
Sugammadex vs Neostigmine for Reversal of Neuromuscular Blockade and Association with Postoperative Atelectasis After Video-Assisted Thoracoscopic Surgery: A Propensity Score-Matched Cohort Study [0.03%]
Kuo-Chuan Hung,Hsiu-Lan Weng,Jheng-Yan Wu et al.
Kuo-Chuan Hung et al.
Purpose: Postoperative atelectasis remains a significant concern after video-assisted thoracoscopic surgery (VATS). This study aimed to evaluate the association between sugammadex use and postoperative atelectasis in pati...
Comparative Study
Drug design, development and therapy. 2026 Mar 6:20:593657. DOI:10.2147/DDDT.S593657 2026
Perioperative EGFR-Targeted Therapy in Resectable EGFR-Mutated NSCLC: A Narrative Review from Drug Design to Pain-Informed MRD-Guided Care [0.03%]
Lile Xiong,Xiufen Yang,Hua Yuan et al.
Lile Xiong et al.
Perioperative EGFR-targeted therapy has transformed the management of resectable EGFR-mutated NSCLC. However, prolonged exposure introduces chronic toxicity and pain that may erode long-term benefit. This narrative review synthesizes eviden...
ED90 of Remimazolam for Moderate Sedation in Children Undergoing Neurosurgery [0.03%]
用于接受神经外科手术的儿童中度镇静的remimazolam的ED90剂量响应关系研究
Fei-Yu Tao,Yan-Jie Yang,Lu-Chao Gao et al.
Fei-Yu Tao et al.
Background: Preoperative sedation is critical to alleviate anxiety in children undergoing neurosurgery, but the role of remimazolam is still uncertain such as its unestablished dosing and safety. This study was aimed to d...
Effect of Preoperative Esketamine Nebulized Inhalation on Cough Reflex, Sedation, and Postoperative Sore Throat in Extubation of Surgical Patients: A Prospective, Double-Blind, Randomized Controlled Trial [0.03%]
术前右美托咪啶雾化吸入对术后拔管患者咳嗽反射、镇静及咽痛的影响：一项前瞻性双盲随机对照试验
Zheng-Qin Zhang,Rui Yang,Jing-Jing Li et al.
Zheng-Qin Zhang et al.
Purpose: This study aims to explore the effect of preoperative esketamine nebulized inhalation on cough reflex during extubation for surgical patients who received general anesthesia. ...