Integration of Network Pharmacology, Transcriptomics, and Metabolomics Strategies to Uncover the Mechanism of Chaihuang Qingfu Pill in Treating Sepsis-Induced Liver Injury [0.03%]
基于网络药理学、转录组学及代谢组学探讨柴胡清肺颗粒治疗脓毒症肝损伤的机制研究
Chenbin Zhang,Fang Chen,Yu Jiang et al.
Chenbin Zhang et al.
Background: Sepsis is a critical condition triggered by infection and characterized by systemic inflammation and subsequent multiorgan failure. Chaihuang Qingfu Pill (CHQF), an in-hospital formulation developed by Hunan P...
Sheng-Jiang Powder Alleviates Th17/Treg Immune Imbalance of Experimental Autoimmune Encephalomyelitis by Regulating the Fatty Acids Metabolism [0.03%]
细辛粉末通过调节脂肪酸代谢改善实验性自身免疫性脑脊髓炎的Th17/Treg失衡
Lulu Wu,Haoyou Xu,Hui Xia et al.
Lulu Wu et al.
Background: Multiple sclerosis (MS) is one of the leading causes of disability among young people, and the immune imbalance between T helper cell 17 (Th17) and regulatory T cells (Tregs) plays a crucial role in its pathog...
The Influence of Age on the Effective Dosage of Intravenous Remimazolam for the Relief of Preoperative Anxiety in Pediatric Patients at Median and 95% Effective Doses: A Prospective Study [0.03%]
年龄对儿童患者中位数和95％有效剂量下静脉注射remimazolam缓解术前焦虑的影响：一项前瞻性研究
Yueyue Chen,Wenhua Zhang,Junyi Ma et al.
Yueyue Chen et al.
Purpose: Preoperative anxiety is an urgent problem in pediatric patients. This trial evaluated intravenous remimazolam for preoperative sedation in pediatric patients, assessing efficacy, safety, and age-dependent dose ef...
The Efficacy of Sodium Bicarbonate Ringer's Solution and Lactate Ringer's Solution in Patients Undergoing Long-Term Abdominal Open Surgery: A Multicenter Prospective Randomized Controlled Study [0.03%]
碳酸氢盐林格液和乳酸林格液在长时间开腹手术患者中有效性的多中心前瞻性随机对照研究
Susu Zhou,Kai Zhao,Chunmei Liu et al.
Susu Zhou et al.
Purpose: Sodium bicarbonate Ringer's solution (BRS) is an intravenous fluid that does not rely on hepatic or renal metabolism. It contains bicarbonate ions (HCO3 -) and lacks lactate ions. This study hypothesizes that BRS...
Rhein Alleviates Cisplatin-Induced Acute Kidney Injury via Downregulation of NOX4-COX2/PGFS Signaling Pathway [0.03%]
Rhein通过下调NOX4-COX2/PGFS信号通路缓解顺铂引起的急性肾损伤
Xi Yuan,Luosha Long,Minghui Wang et al.
Xi Yuan et al.
Purpose: Cisplatin (cis-diamminedichloroplatinum II, CDDP), a widely used chemotherapeutic agent, is clinically limited by nephrotoxicity. Rhein, an anthraquinone from Radix Rhein Et Rhizome, shows nephroprotective potent...
Effect of Intraoperative Intravenous Infusion of Esketamine Combined with Dexmedetomidine on Postoperative Sleep Disturbance in Patients Undergoing Radical Mastectomy [0.03%]
右美托咪定联合艾司氯胺酮围术期输注对乳腺癌根治术患者术后睡眠障碍的影响
Xingyu Geng,Yutian Pu,Ziwei Hu et al.
Xingyu Geng et al.
Objective: Postoperative sleep disturbance(POSD) is a problem in breast cancer patients after surgery. Little is known about the differences in the treatment of POSD with esketamine combined with dexmedetomidine under the...
Randomized Controlled Trial
Drug design, development and therapy. 2025 May 31:19:4629-4640. DOI:10.2147/DDDT.S510222 2025
Mechanistic Exploration of Shugan Jianpi Formula for Treating Triple-Negative Breast Cancer Under Chronic Stress: A Network Pharmacology-Guided Experimental Study [0.03%]
基于网络药理学指导下的舒肝健脾方治疗慢性应激三阴性乳腺癌的机制探索研究
Fen Liu,Luning Li,Yiming Zhang et al.
Fen Liu et al.
Purpose: This study aimed to investigate the pharmacological mechanisms of Shugan Jianpi Formula (SGJPF) in treating TNBC using network pharmacology and molecular biology approaches. ...
Effects of Remimazolam Tosilate Combined with Esketamine on Anesthetic Efficacy and Psychiatric Symptoms in Patients Undergoing Ambulatory Surgery: A Randomized Controlled Study [0.03%]
托瑞米松联合艾司氯胺酮对门诊手术患者麻醉效果及精神症状的影响：一项随机对照研究
Xuan Yu,Xinpeng Xu,Jing Wang et al.
Xuan Yu et al.
Background: The choice of anesthetic drugs is crucial in ambulatory surgery. Esketamine has anesthetic, analgesic, and sedative effects, but it is associated with dose-dependent psychiatric symptoms. Benzodiazepines can a...
Dolutegravir Derivatives Alleviate LPS-Induced Microglial Inflammation by Suppressing STAT1/3 Nuclear Translocation [0.03%]
多替拉韦衍生物通过抑制STAT1/3核转位缓解LPS诱导的小胶质细胞炎症
Lan Wang,Xiaoting Zhang,Yimian Wang et al.
Lan Wang et al.
Purpose: Microglial inflammation plays a significant role in a variety of neurological disorders. Dolutegravir as a antiretroviral drug has been reported to inhibit the secretion of pro-inflammatory cytokines. Meanwhile, ...
Mechanisms of Zanthoxyli Pericarpium-Zingiberis Rhizoma in the Treatment of Gastric Cancer Based on Network Pharmacology and Experimental Validation [0.03%]
基于网络药理学和实验验证的木香槟榔联合生姜治疗胃癌的作用机制研究
Qian Gu,Shuai Duan,Joanna Japhet Tibenda et al.
Qian Gu et al.
Background: Malignant tumors, as a major challenge in global public health, have posed a significant threat to human life and health. Although traditional chemotherapy can inhibit tumor growth, it is often associated with...