Stachydrine: A Systematic Review of Its Multi-Targeted Therapeutic Potential in Cardiovascular, Oncology, Renal, Gynecological, and Inflammatory Disorders [0.03%]
Songlin Tang,Yongpan Huang
Songlin Tang
Background: Stachydrine, a principal bioactive alkaloid derived from Leonurus japonicus (motherwort), has attracted significant interest due to its diverse pharmacological activities and nutritional relevance. This system...
Baicalin as a Multifunctional Regulator of Gut Health: Integrative Mechanisms Involving Inflammation, Barrier Integrity, and Gut-Organ Axis [0.03%]
Weiyu Zhu,Chaoyi Jia,Tianyuan Fei et al.
Weiyu Zhu et al.
Intestinal health is sustained by coordinated control of mucosal immunity, epithelial barrier integrity, and the gut microbiota and its metabolites. Disruption of these tightly coupled systems contributes to a wide spectrum of disorders, ra...
Exploring Chinese Herbal Medicines for Acute Kidney Injury: Pharmacological Mechanisms and Clinical Potential [0.03%]
Yuan Zhou,Sijia Li,Minghai Shao et al.
Yuan Zhou et al.
Background: Acute kidney injury (AKI) is a serious clinical condition marked by a rapid decline in renal function, leading to high morbidity, mortality, and healthcare burden. Despite advances in supportive care, effectiv...
Nanoencapsulated α-Mangostin Loaded Chitosan-Alginate Hydrogel Films for Enhanced Topical Anti Acne Therapy [0.03%]
Nia Yuniarsih,Anis Yohana Chaerunisaa,Ahmed Fouad Abdelwahab Mohammed et al.
Nia Yuniarsih et al.
Background: α-Mangostin (α-M) is a natural antimicrobial and anti-inflammatory compound with promising anti-acne potential; however, its poor solubility and instability limit its topical use. This study developed and ev...
High-Dose Propofol Induces Cytotoxicity by Elevating Intracellular Ca2⁺ via GABAA Receptor and IP3R in HT22 Cells [0.03%]
Hao Zhou,Huimin Zhou,Xi Tan et al.
Hao Zhou et al.
Objective: Disruption of calcium (Ca2⁺) homeostasis has been implicated as a key pathological mechanism underlying propofol-induced neurodevelopmental and cognitive deficits. However, the mechanisms underlying propofol-i...
Sugammadex for Neuromuscular Blockade Reversal and Postoperative Recovery in Laparoscopic Bariatric Surgery: A Randomized Controlled Trial [0.03%]
Qian-Qian Wang,Jun-Li Duan,Ling-Tong Li et al.
Qian-Qian Wang et al.
Objective: The aim of this study was to evaluate the effect of sugammadex on the quality of postoperative recovery among patients undergoing laparoscopic bariatric surgery. ...
From Methotrexate Resistance to Biologic and Targeted Pharmacotherapy: A Decade of Phase 4 Clinical Trials Evidence in Rheumatoid Arthritis [0.03%]
Shaker T Alsharif
Shaker T Alsharif
Background: Methotrexate (MTX) remains the cornerstone of rheumatoid arthritis (RA) management; however, up to 30-40% of patients experience inadequate response or intolerance, necessitating escalation to advanced therape...
Effects of Voriconazole on the Safety, Pharmacokinetics and Pharmacodynamics of Ciprofol (HSK3486), a Novel Intravenous Anaesthetic, in Healthy Participants: A Prospective, Randomized, Crossover Clinical Trial [0.03%]
Yicong Bian,Tao Hu,Qingqing Deng et al.
Yicong Bian et al.
Purpose: Ciprofol, a novel intravenous anaesthetic, is an analogue of propofol with superior anaesthetic efficacy. Ciprofol is widely metabolized in humans, and cytochrome P450 enzymes (CYPs) are involved in its metabolis...
Randomized Controlled Trial
Drug design, development and therapy. 2026 Jan 8:20:562125. DOI:10.2147/DDDT.S562125 2026
Circadian Variation in Ropivacaine Requirement for Initiation of Epidural Labour Analgesia: A Random-Allocation Graded Dose-Response Study [0.03%]
Xiao-Dong Huang,Fei Xiao,Bing Hu et al.
Xiao-Dong Huang et al.
Purpose: There is evidence that labor pain and the doses of drugs used to treat it exhibit circadian variation. Previously, we reported that during the night, the effective dose (ED50) of epidural ropivacaine for labor an...
Fosaprepitant versus Ondansetron for Preventing Postoperative Nausea and Vomiting After Video-Assisted Thoracoscopic Lung Resection: A Randomized Controlled Clinical Trial [0.03%]
Xiuqing Qi,Jinying Zhang,Jiaojiao Sun et al.
Xiuqing Qi et al.
Purpose: Postoperative nausea and vomiting (PONV) is a frequent complication after video-assisted thoracoscopic lung resection, particularly in patients at moderate to high risk, and substantially hinders recovery. Fosapr...