Clinical utility of targeted treatments in the management of epithelial ovarian cancer [0.03%]
靶向治疗在上皮性卵巢癌管理中的临床效用
Cheryl Twu,Ernest S Han
Cheryl Twu
Epithelial ovarian cancer is typically found in its advanced stages, where a combination of surgical debulking and platinum/taxane-based chemotherapy is recommended. Although over 70%-80% of patients achieve remission, a significant proport...
Nitin Patil,Mohammed Abba,Heike Allgayer
Nitin Patil
Cancer progression is a highly complex process that is driven by a constellation of deregulated signaling pathways and key molecular events. In non-small-cell lung cancer (NSCLC), as in several other cancer types, the epidermal growth facto...
Hepatocellular carcinoma: natural history, current management, and emerging tools [0.03%]
肝细胞癌：自然史、现有的治疗方法及新兴的辅助工具
Christopher L Tinkle,Daphne Haas-Kogan
Christopher L Tinkle
Hepatocellular carcinoma (HCC) is the most common primary liver tumor and represents the third-leading cause of cancer-related death in the world. The incidence of HCC continues to increase worldwide, with a unique geographic, age, and sex ...
Sustained maintenance of clinical remission after adalimumab dose reduction in patients with early psoriatic arthritis: a long-term follow-up study [0.03%]
阿达木单抗减量对早期银屑病关节炎患者临床缓解的维持作用：一项长期随访研究
Fabrizio Cantini,Laura Niccoli,Emanuele Cassarà et al.
Fabrizio Cantini et al.
Purpose: The primary purpose of this study was to evaluate the proportion of psoriatic arthritis (PsA) patients maintaining clinical remission after adalimumab (ADA) dose reduction compared with patients with rheumatoid a...
Significant neutralizing activities against H2N2 influenza A viruses in human intravenous immunoglobulin lots manufactured from 1993 to 2010 [0.03%]
1993至2010年生产的丙种球蛋白中具有针对H2N2亚型流感病毒的显著中和活性
Ritsuko Kubota-Koketsu,Mikihiro Yunoki,Yoshinobu Okuno et al.
Ritsuko Kubota-Koketsu et al.
Influenza A H2N2 virus, also known as the Asian flu, spread worldwide from 1957 to 1967, although there have been no cases reported in humans in the past 40 years. A vaccination program was introduced in Japan in the 1960s. Older Japanese d...
Rituximab is more effective than second anti-TNF therapy in rheumatoid arthritis patients and previous TNFα blocker failure [0.03%]
对于TNFα拮抗剂治疗失败的类风湿关节炎患者，利妥昔单抗比二线肿瘤坏死因子拮抗剂更有效
Joern Kekow,Ulf Mueller-Ladner,Hendrik Schulze-Koops
Joern Kekow
Purpose: To assess the efficacy of one course of rituximab (two 1-g doses) compared to an alternative tumor necrosis factor-α (TNFα) blocker in rheumatoid arthritis patients who had experienced one previous TNFα blocke...
Steve Elliott,Angus M Sinclair
Steve Elliott
Erythropoietin (Epo) is an essential hormone that binds and activates the Epo receptor (EpoR) resident on the surface of erythroid progenitor cells, thereby promoting erythropoiesis. Recombinant human erythropoietin has been used successful...
Effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate? [0.03%]
生物制剂对类风湿关节炎影像学进展的影响：是否比甲氨蝶呤更有优势？
Graeme Jones,Erica Darian-Smith,Michael Kwok et al.
Graeme Jones et al.
There have been substantial advances in the treatment of rheumatoid arthritis in recent years. Traditional disease-modifying antirheumatic drugs (DMARDs) have been shown to have small effects on the progression of radiographic damage. This ...
Carole Sourbier
Carole Sourbier
With about 22,000 new cases estimated in 2012 in the US and 15,500 related deaths, ovarian cancer is a heterogeneous and aggressive disease. Even though most of patients are sensitive to chemotherapy treatment following surgery, recurring d...
Judith Meza-Junco,Michael B Sawyer
Judith Meza-Junco
Gastric cancer (GC) is currently the second leading cause of cancer death worldwide; unfortunately, most patients will present with locally advanced or metastatic disease. Despite recent progress in diagnosis, surgery, chemotherapy, and rad...