Effects and Safety of Linagliptin as an Add-on Therapy in Advanced-Stage Diabetic Nephropathy Patients Taking Renin-Angiotensin-Aldosterone System Blockers [0.03%]
利格列汀在使用肾素-血管紧张素-醛固酮系统阻滞剂的糖尿病肾病综合症晚期患者中的疗效及安全性研究
Yuichiro Ueda,Hiroki Ishii,Taisuke Kitano et al.
Yuichiro Ueda et al.
Background: We investigated the effects and safety of linagliptin as an add-on therapy in patients with advanced-stage diabetic nephropathy (DMN) taking renin-angiotensin-aldosterone system (RAAS) blockers. ...
Gentamicin-Impregnated Collagen Sponge: Effectiveness in Preventing Sternal Wound Infection in High-Risk Cardiac Surgery [0.03%]
含金霉素胶原海绵防治高危冠脉手术患者胸骨伤口感染的有效性研究
Filippo Rapetto,Vito D Bruno,Gustavo Guida et al.
Filippo Rapetto et al.
Sternal wound infections represent one of the most frequent complications after cardiac surgery and are associated with high postoperative mortality. Several preventive methods have been introduced, and recently, gentamicin-impregnated coll...
Paraskevi Fragkou,Maria Souli,Maria Theochari et al.
Paraskevi Fragkou et al.
Until recently, chemotherapy for metastatic melanoma had disappointing results. The identification of immune checkpoints such as CTLA-4 and PD-1/PD-L1 has led to the development of an array of monoclonal antibodies (Mabs). These immunologic...
Case Reports
Drug target insights. 2016 May 22:10:9-12. DOI:10.4137/DTI.S31565 2016
Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose [0.03%]
脑组胺N-甲基转移酶可能是冰毒中毒的治疗靶点
Junichi Kitanaka,Nobue Kitanaka,F Scott Hall et al.
Junichi Kitanaka et al.
Stereotypical behaviors induced by methamphetamine (METH) overdose are one of the overt symptoms of METH abuse, which can be easily assessed in animal models. Currently, there is no successful treatment for METH overdose. There is increasin...
Preliminary In Vivo Evaluation of a Hybrid Armored Vascular Graft Combining Electrospinning and Additive Manufacturing Techniques [0.03%]
结合静电纺丝和增材制造技术的杂化血管移植物的体内初步评估研究
Cristiano Spadaccio,Francesco Nappi,Federico De Marco et al.
Cristiano Spadaccio et al.
In this study, we tested in vivo effectiveness of a previously developed poly-l-lactide/poly-ε-caprolactone armored vascular graft releasing heparin. This bioprosthesis was designed in order to overcome the main drawbacks of tissue-enginee...
Screening Analogs of β-OG Pocket Binder as Fusion Inhibitor of Dengue Virus 2 [0.03%]
筛选登革热病毒2型融合抑制剂β-OG结合袋类类似物
Usman Sf Tambunan,Hilyatuz Zahroh,Arli A Parikesit et al.
Usman Sf Tambunan et al.
Dengue is an infectious disease caused by dengue virus (DENV) and transmitted between human hosts by mosquitoes. Recently, Indonesia was listed as a country with the highest cases of dengue by the Association of Southeast Asian Nations. The...
Management of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume Retention [0.03%]
与肾病综合征相关糖尿病的管理：达格列净治疗持续性容量潴留的潜在疗效
Toshimi Imai,Tetsu Akimoto,Chiharu Ito et al.
Toshimi Imai et al.
A 48-year-old female was admitted to our hospital presenting with a chief complaint of progressive swelling because of diabetic nephrotic syndrome. Dapagliflozin seemed to play a role in accelerating the patient's urinary sodium excretion a...
Case Reports
Drug target insights. 2015 Nov 11:9:29-31. DOI:10.4137/DTI.S31710 2015
Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection [0.03%]
回肠造口术后的炎症性肠病患者血浆copeptin水平升高
Bodil Ohlsson,Olle Melander
Bodil Ohlsson
Evidence of interactions between the enteric nervous system, neuropeptides, and the immune system is growing. The aim of this study was to examine basal plasma levels of a variety of peptide precursors in patients with inflammatory bowel di...
Medicinal Plants: A Potential Source of Compounds for Targeting Cell Division [0.03%]
药用植物：一种针对细胞分裂的化合物潜在来源
Ihsan N Zulkipli,Sheba R David,Rajan Rajabalaya et al.
Ihsan N Zulkipli et al.
Modern medicinal plant drug discovery has provided pharmacologically active compounds targeted against a multitude of conditions and diseases, such as infection, inflammation, and cancer. To date, natural products from medicinal plants rema...
7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice [0.03%]
7-尼和ODQ干扰小鼠增强型十字迷宫、莫里斯水迷宫及空间八臂迷宫试验中的记忆形成
Oguz Mutlu,Furuzan Akar,Ipek Komsuoglu Celikyurt et al.
Oguz Mutlu et al.
Nitric oxide (NO) is an atypical neurotransmitter that causes changes in cognition. Nitric oxide synthase (NOS) and guanylate cyclase (GC) inhibitors have been shown to exert some effects on cognition in previous studies; however, the findi...