Targeting Streptococcus pneumoniae UDP-glucose pyrophosphorylase (UGPase): in vitro validation of a putative inhibitor [0.03%]
靶向肺炎链球菌尿苷二磷酸葡萄糖焦磷酸化酶（UGPase）：潜在抑制剂的体外验证研究
Monica Sharma,Swati Sharma,Pallab Ray et al.
Monica Sharma et al.
Background: Genome plasticity of Streptococcus pneumoniae is responsible for the reduced efficacy of various antibiotics and capsular polysaccharide-based vaccines. Therefore, targets independent of capsular types are sou...
Prevalence of multidrug-resistant and extended-spectrum beta-lactamase (ESBL)-producing gram-negative bacilli: A meta-analysis report in Ethiopia [0.03%]
埃塞俄比亚多重耐药及广谱β-内酰胺酶（ESBL）产生革兰氏阴性菌的流行率：一项荟萃分析报告
Mengistu Abayneh,Teshale Worku
Mengistu Abayneh
Multidrug-resistant (MDR) extended-spectrum beta-lactamase (ESBL)-producing bacterial isolates have emerged as a global threat to human health. Little is known about the overall prevalence of multidrug resistance profile and ESBL-producing ...
Khadija Ayed,Islam Latifa Hadj Khalifa,Salma Mokaddem et al.
Khadija Ayed et al.
Introduction: Salbutamol and terbutaline are short-acting β2 adrenergic agonists that produce bronchial smooth muscle relaxation and are widely used in obstructive pulmonary diseases. Nevertheless, their use has been the...
Identification of the possible therapeutic targets in the insulin-like growth factor 1 receptor pathway in a cohort of Egyptian hepatocellular carcinoma complicating chronic hepatitis C type 4 [0.03%]
在埃及四型慢性丙型肝炎并发的肝细胞癌队列中鉴定胰岛素样生长因子1受体途径的潜在治疗靶点
Nada M K Mabrouk,Dalal M Elkaffash,Mona Abdel-Hadi et al.
Nada M K Mabrouk et al.
Background: Molecular targeted drugs are the first line of treatment of advanced hepatocellular carcinoma (HCC) due to its chemo- and radioresistant nature. HCC has several well-documented etiologic factors that drive hep...
Kathleen B Orrico
Kathleen B Orrico
This basic review of genetic principles will aid pharmacists in preparing for their eventual role of translating gene-drug associations into clinical practice. Genes, which are stretches of deoxyribonucleic acid (DNA) contained on the 23 pa...
Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies [0.03%]
健忘症疾病中具有神经保护作用的 Bacopa monnieri 领导研究：其属性，作用机制及药理和临床试验综述
Aimi Syamima Abdul Manap,Shantini Vijayabalan,Priya Madhavan et al.
Aimi Syamima Abdul Manap et al.
Alzheimer disease is a neurodegenerative disease that is signified by cognitive decline, memory loss, and erratic behavior. Till date, no cure for Alzheimer exists and the current Alzheimer medications have limited effectiveness. However, h...
Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies [0.03%]
健忘症疾病中的神经保护因素—— Bacopa monnieri lead：关于其特性，作用机制及前期和临床研究的综述
Aimi Syamima Abdul Manap,Shantini Vijayabalan,Priya Madhavan et al.
Aimi Syamima Abdul Manap et al.
Alzheimer disease is a neurodegenerative disease that is signified by cognitive decline, memory loss, and erratic behavior. Till date, no cure for Alzheimer exists and the current Alzheimer medications have limited effectiveness. However, h...
Crhistian-Mario Oblitas,Francisco Galeano-Valle,Laura Vela-De La Cruz et al.
Crhistian-Mario Oblitas et al.
A 43-year-old man with a history of severe extrinsic allergic asthma treated with once-monthly omalizumab (600 mg) for the last 15 months. He presented to the emergency room with a 2-week history of right lower limb pain and chest pleuritic...
Vernakalant in Atrial Fibrillation: A Relatively New Weapon in the Armamentarium Against an Old Enemy [0.03%]
Vernakalant在房颤治疗中的地位：抵抗旧敌的新式武器
Antoine Kossaify
Antoine Kossaify
Atrial fibrillation is the most common sustained cardiac arrhythmia, and its prevalence is increasing with age; also it is associated with significant morbidity and mortality. Rhythm control is advised in recent-onset atrial fibrillation, a...
A Comprehensive Review of Pegvaliase, an Enzyme Substitution Therapy for the Treatment of Phenylketonuria [0.03%]
佩加利塞酶替代疗法治疗苯酮尿症的全面回顾
Tasmina Hydery,Valerie Azzopardi Coppenrath
Tasmina Hydery
Objective: To review the pharmacology, pharmacokinetics, efficacy, safety, and place in therapy of a phenylalanine-metabolizing enzyme indicated to reduce blood phenylalanine concentrations, pegvaliase injection. ...