The association of ESBL Escherichia coli with mortality in patients with Escherichia coli bacteremia at the emergency department [0.03%]
产ESBL大肠埃希菌血症与急诊科患者的死亡率相关性研究
Pariwat Phungoen,Jessada Sarunyaparit,Korakot Apiratwarakul et al.
Pariwat Phungoen et al.
Background:: Escherichia coli is a common bloodstream infection pathogen in the emergency department (ED). Patients with extended-spectrum beta-lactamase (ESBL) E. coli have a higher risk of morbidity. However, there is s...
Anatomical and functional responses to single brolucizumab injection in neovascular age-related macular degeneration patients not responding to antiangiogenics: a case series [0.03%]
抗血管内皮生长因子治疗无效的湿性年龄相关性黄斑变性患者单次注射brolucizumab后的解剖和功能反应：病例系列研究报告
Silvio Zuccarini,Fabrizio Puce,Alessandro Crisà
Silvio Zuccarini
Introduction:: Neovascular age-related macular degeneration (nAMD) is treated with antivascular endothelial growth factor (anti-VEGF) drugs. However, resistance to anti-VEGF therapy is observed in some patients. Brolucizu...
Erythrodermic psoriasis and palmoplantar hyperkeratosis successfully treated with secukinumab: a case report [0.03%]
塞库奴单抗治疗红皮病型银屑病和掌跖部角化过度1例报告
Martino Carriero
Martino Carriero
Introduction:: Erythrodermic psoriasis (EP) is a rare and severe form of psoriasis that affects 1% to 2.25% of patients, increasing mortality risk. To date, very few therapies have been approved for the treatment of this ...
Case Reports
Drug target insights. 2022 Mar 7:16:1-5. DOI:10.33393/dti.2022.2355 2022
Hexarelin modulates lung mechanics, inflammation, and fibrosis in acute lung injury [0.03%]
六氢relin调节急性肺损伤的肺力学，炎症和纤维化
Vanessa Zambelli,Laura Rizzi,Paolo Delvecchio et al.
Vanessa Zambelli et al.
Introduction:: Acute respiratory distress syndrome (ARDS) is an acute form of diffuse lung injury characterized by (i) an intense inflammatory response, (ii) increased pulmonary vascular permeability, and (iii) the loss o...
Clinical factors predictive of appropriate treatment in COPD: a community hospital setting [0.03%]
社区医院COPD适当治疗的临床预测因素
Sukanya Tongdee,Bundit Sawunyavisuth,Wattana Sukeepaisarnjaroen et al.
Sukanya Tongdee et al.
Background:: Chronic obstructive pulmonary disease (COPD) is a common respiratory disease. The appropriate treatment according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline was 19-60%. How...
The role of patient preferences in adherence to treatment in chronic disease: a narrative review [0.03%]
患者偏好在慢性疾病治疗依从性中的作用：一项叙述性综述
Serena Losi,Cesare Celeste Federico Berra,Riccardo Fornengo et al.
Serena Losi et al.
Adherence to prescribed medication is important to the management of all diseases, especially those of chronic nature. Drug effectiveness is substantially compromised by therapy nonadherence. We reviewed the available evidences on the impac...
Tamarind (Tamarindus indica L.) Seed a Candidate Protein Source with Potential for Combating SARS-CoV-2 Infection in Obesity [0.03%]
番石榴子作为潜在的蛋白质来源在肥胖人群对抗SARS-CoV-2感染中的作用
Ana H de A Morais,Amanda F de Medeiros,Isaiane Medeiros et al.
Ana H de A Morais et al.
Introduction:: Obesity and coronavirus disease (COVID)-19 are overlapping pandemics, and one might worsen the other. Methods:: This nar...
Corticosteroid treatment reduces headache in eosinophilic meningitis: a systematic review [0.03%]
糖皮质激素治疗可减轻嗜酸细胞性脑膜炎患者的头痛症状：系统性综述
Sittichai Khamsai,Kittisak Sawanyawisuth,Vichai Senthong et al.
Sittichai Khamsai et al.
Background:: Eosinophilic meningitis (EOM) is an emerging parasitic disease that can be found worldwide, of which acute severe headache is a presenting symptom. Although such headaches may persist for up to 2 months, stud...
Hironori Tsuchiya,Maki Mizogami
Hironori Tsuchiya
Introduction: Plasma membranes are not the homogeneous bilayers of uniformly distributed lipids but the lipid complex with laterally separated lipid raft membrane domains, which provide receptor, ion channel and enzyme pr...
Targeting Streptococcus pneumoniae UDP-glucose pyrophosphorylase (UGPase): in vitro validation of a putative inhibitor [0.03%]
靶向肺炎链球菌尿苷二磷酸葡萄糖焦磷酸化酶（UGPase）：潜在抑制剂的体外验证研究
Monica Sharma,Swati Sharma,Pallab Ray et al.
Monica Sharma et al.
Background: Genome plasticity of Streptococcus pneumoniae is responsible for the reduced efficacy of various antibiotics and capsular polysaccharide-based vaccines. Therefore, targets independent of capsular types are sou...