Exploring the inhibitory mechanisms of indazole compounds against SAH/MTAN-mediated quorum sensing utilizing QSAR and docking [0.03%]
基于QSAR和对接的吲唑类化合物抑制SAH/MTAN介导的群体感应机制研究
Sisir Nandi,Mohit Kumar,Rashmi Kumari et al.
Sisir Nandi et al.
The world is under the great threat of antimicrobial resistance (AMR) leading to premature deaths. Microorganisms can produce AMR via quorum sensing mechanisms utilizing S-adenosyl homocysteine/methylthioadenosine nucleosidase (SAH/MTAN) bi...
Antimicrobial resistance surveillance system mapping in different countries [0.03%]
不同国家的抗菌素耐药性监测系统绘图
Ramendra Pati Pandey,Riya Mukherjee,Chung-Ming Chang
Ramendra Pati Pandey
Objectives:: Excessive use of antibiotics has increased antimicrobial resistance (AMR) worldwide, which is a major public concern among the countries. To control this threat proper monitoring of the antimicrobial usage wi...
Understanding the environmental drivers of clinical azole resistance in Aspergillus species [0.03%]
理解环境因素对曲霉属物种临床唑类抗性的影响
Pooja Sen,Mukund Vijay,Shweta Singh et al.
Pooja Sen et al.
Aspergilli are ubiquitous fungal pathogens associated with severe life-threatening infections, especially in immunocompromised patients. Azoles are the first line of defence in the fight against most Aspergillus-related infections. However,...
Redefining genomic view of Clostridioides difficile through pangenome analysis and identification of drug targets from its core genome [0.03%]
通过泛基因组分析及其核心基因组中药物靶标的鉴定来重新定义艰难梭状芽胞杆菌的基因组观点
Nikita Chordia Golchha,Anand Nighojkar,Sadhana Nighojkar
Nikita Chordia Golchha
Introduction:: Clostridioides difficile infection (CDI) is a leading cause of gastrointestinal infections and in the present day is a major concern for global health care system. The unavailability of specific antibiotics...
The association of ESBL Escherichia coli with mortality in patients with Escherichia coli bacteremia at the emergency department [0.03%]
产ESBL大肠埃希菌血症与急诊科患者的死亡率相关性研究
Pariwat Phungoen,Jessada Sarunyaparit,Korakot Apiratwarakul et al.
Pariwat Phungoen et al.
Background:: Escherichia coli is a common bloodstream infection pathogen in the emergency department (ED). Patients with extended-spectrum beta-lactamase (ESBL) E. coli have a higher risk of morbidity. However, there is s...
Anatomical and functional responses to single brolucizumab injection in neovascular age-related macular degeneration patients not responding to antiangiogenics: a case series [0.03%]
抗血管内皮生长因子治疗无效的湿性年龄相关性黄斑变性患者单次注射brolucizumab后的解剖和功能反应：病例系列研究报告
Silvio Zuccarini,Fabrizio Puce,Alessandro Crisà
Silvio Zuccarini
Introduction:: Neovascular age-related macular degeneration (nAMD) is treated with antivascular endothelial growth factor (anti-VEGF) drugs. However, resistance to anti-VEGF therapy is observed in some patients. Brolucizu...
Erythrodermic psoriasis and palmoplantar hyperkeratosis successfully treated with secukinumab: a case report [0.03%]
塞库奴单抗治疗红皮病型银屑病和掌跖部角化过度1例报告
Martino Carriero
Martino Carriero
Introduction:: Erythrodermic psoriasis (EP) is a rare and severe form of psoriasis that affects 1% to 2.25% of patients, increasing mortality risk. To date, very few therapies have been approved for the treatment of this ...
Case Reports
Drug target insights. 2022 Mar 7:16:1-5. DOI:10.33393/dti.2022.2355 2022
Hexarelin modulates lung mechanics, inflammation, and fibrosis in acute lung injury [0.03%]
六氢relin调节急性肺损伤的肺力学，炎症和纤维化
Vanessa Zambelli,Laura Rizzi,Paolo Delvecchio et al.
Vanessa Zambelli et al.
Introduction:: Acute respiratory distress syndrome (ARDS) is an acute form of diffuse lung injury characterized by (i) an intense inflammatory response, (ii) increased pulmonary vascular permeability, and (iii) the loss o...
Clinical factors predictive of appropriate treatment in COPD: a community hospital setting [0.03%]
社区医院COPD适当治疗的临床预测因素
Sukanya Tongdee,Bundit Sawunyavisuth,Wattana Sukeepaisarnjaroen et al.
Sukanya Tongdee et al.
Background:: Chronic obstructive pulmonary disease (COPD) is a common respiratory disease. The appropriate treatment according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline was 19-60%. How...
The role of patient preferences in adherence to treatment in chronic disease: a narrative review [0.03%]
患者偏好在慢性疾病治疗依从性中的作用：一项叙述性综述
Serena Losi,Cesare Celeste Federico Berra,Riccardo Fornengo et al.
Serena Losi et al.
Adherence to prescribed medication is important to the management of all diseases, especially those of chronic nature. Drug effectiveness is substantially compromised by therapy nonadherence. We reviewed the available evidences on the impac...