RBD mutations at the residues K417, E484, N501 reduced immunoreactivity with antisera from vaccinated and COVID-19 recovered patients [0.03%]
RBD位点K417、E484和N501突变降低了与疫苗接种或新冠康复者血清的反应性
Dablu Lal Gupta,Jhasketan Meher,Anjan Kumar Giri et al.
Dablu Lal Gupta et al.
Introduction: It is unclear whether induced spike protein-specific antibodies due to infections with SARS-CoV-2 or to the prototypic Wuhan isolate-based vaccination can immune-react with the emerging variants of SARS-CoV-...
Nerges F Mistry
Nerges F Mistry
The dark side of drug repurposing. From clinical trial challenges to antimicrobial resistance: analysis based on three major fields [0.03%]
药物再利用的阴暗面：从临床试验挑战到抗微生物药物耐药性：基于三大领域的分析
Iyad Y Natsheh,Majd M Alsaleh,Ahmad K Alkhawaldeh et al.
Iyad Y Natsheh et al.
Drug repurposing is a strategic endeavor that entails the identification of novel therapeutic applications for pharmaceuticals that are already available in the market. Despite the advantageous nature of implementing this particular strateg...
Long-term response with the atypical reaction to nivolumab in microsatellite stability metastatic colorectal cancer: A case report [0.03%]
nivolumab对微卫星稳定转移性结直肠癌的长期非典型反应一例报告
Nataliya Babyshkina,Nataliya Popova,Evgeny Grigoryev et al.
Nataliya Babyshkina et al.
Immunotherapy has become an integral part of a comprehensive treatment approach to metastatic colorectal cancer (mCRC). Nivolumab (Opdivo) is a human immunoglobulin G4 monoclonal antibody that blocks the interaction between the programmed c...
Case Reports
Drug target insights. 2024 Jan 23:18:4-7. DOI:10.33393/dti.2024.2637 2024
Evaluation of non-conformities in the drafting of bulletins for urine cytobacteriological examinations at Sikasso Hospital (Mali) [0.03%]
评估西索科医院（马里）尿液细胞细菌学检查通报书写中的不合格项目
Luka Diarra,Moussa Mariko,Salif Traore et al.
Luka Diarra et al.
Background: Non-compliance in the drafting of examination bulletins makes it difficult to perform them and interpret the results. With the aim of continuously improving laboratory services and guaranteeing the quality of ...
Management of urinary tract infections in the era of antimicrobial resistance [0.03%]
抗菌素耐药时代尿路感染的治疗
Ria Pothoven
Ria Pothoven
Urinary tract infections (UTIs) are among the most common infections globally, imposing a substantial personal and economic burden on individuals and health resources. Despite international health concerns and sustained public awareness cam...
Mortality rate and factors associated with mortality of carbapenem-resistant Enterobacteriaceae infection [0.03%]
碳氢霉烯耐药肠杆菌感染的病死率及影响死亡的因素分析
Apichart So-Ngern,Naphol Osaithai,Atibordee Meesing et al.
Apichart So-Ngern et al.
Background:: Carbapenem-resistant Enterobacteriaceae (CRE) is a serious pathogen with high mortality. Recognition of factors associated with mortality and treating these modifiable factors are crucial to reducing mortalit...
First-line tepotinib for a very elderly patient with metastatic NSCLC harboring MET exon 14 skipping mutation and high PD-L1 expression [0.03%]
替泊利单抗治疗高PD-L1表达的转移性MET外显子14跳跃突变非小细胞肺癌非常老年患者的一线治疗案例报告
Alessandro Inno,Giuseppe Bogina,Giulio Settanni et al.
Alessandro Inno et al.
Optimal treatment for metastatic non-small cell lung cancer (NSCLC) with mesenchymal epithelial transition gene (MET) exon 14 skipping mutation has not been established yet. MET inhibitors were demonstrated to be effective and tolerated in ...
Case Reports
Drug target insights. 2023 Oct 6:17:110-113. DOI:10.33393/dti.2023.2626 2023
Prevalence of antibiotic misuse in cases of pneumonia and diarrhea in Saudi Arabia [0.03%]
沙特阿拉伯肺炎和腹泻病例中抗生素误用的流行率
Ebtehaj Saud Almughais,Fatmah Fahad Alreshidi,Hussain Gadelkarim Ahmed
Ebtehaj Saud Almughais
Background: Antibiotic misuse is a major public health issue with long-term repercussions. Objective: The purpose of this investigation...
Identification of anti-pathogenic activity among in silico predicted small-molecule inhibitors of Pseudomonas aeruginosa LasR or nitric oxide reductase (NOR) [0.03%]
计算识别假单胞菌LasR或一氧化氮还原酶(NOR)的小分子抑制剂的抗病原作用
Gemini Gajera,Niel Henriksen,Bryan Cox et al.
Gemini Gajera et al.
Introduction: Antibiotic-resistant Pseudomonas aeruginosa strains cause considerable morbidity and mortality globally. Identification of novel targets in this notorious pathogen is urgently warranted to facilitate discove...