Modulation of visceral nociception, inflammation and gastric mucosal injury by cinnarizine [0.03%]
桂利嗪对内脏痛觉过敏、炎症及胃黏膜损伤的调节作用
Omar M E Abdel-Salam
Omar M E Abdel-Salam
The effect of cinnarizine, a drug used for the treatment of vertigo was assessed in animal models of visceral nociception, inflammation and gastric mucosal injury. Cinnarizine (1.25-20 mg/kg, s.c.) caused dose-dependent inhibition of the ab...
Effect of ribavirin alone or combined with silymarin on carbon tetrachloride induced hepatic damage in rats [0.03%]
利巴韦林或与水飞蓟素合用对四氯化碳致大鼠肝损伤的影响
Omar M E Abdel Salam,Amany A Sleem,Enayat A Omara et al.
Omar M E Abdel Salam et al.
The effect of the antiviral agent ribavirin given alone or in combination with silymarin on the development of liver injury induced in rats with carbon tetrachloride (CCl(4); 2.8 ml/kg followed by 1.4 ml/kg after one week) was studied. Riba...
Cyclophilin and viruses: cyclophilin as a cofactor for viral infection and possible anti-viral target [0.03%]
环孢菌素依赖型亲菌蛋白和病毒：亲菌蛋白作为病毒的辅助因子及其潜在抗病毒作用靶点
Koichi Watashi,Kunitada Shimotohno
Koichi Watashi
Cyclophilin (CyP) is a peptidyl prolyl cis/trans isomerase, catalyzing the cis-trans isomerization of proline residues in proteins. CyP plays key roles in several different aspects of cellular physiology including the immune response, trans...
Long-term L-carnitine administration reduces erythropoietin resistance in chronic hemodialysis patients with thalassemia minor [0.03%]
长期左旋肉碱治疗可降低输血依赖性β-地中海贫血维持血液透析患者促红细胞生成素的抵抗作用
Biagio R Di Iorio,Pasquale Guastaferro,Nicola Cillo et al.
Biagio R Di Iorio et al.
Background and aim: Both thalassemia and carnitine deficiency represent independent causes of erythropoietin resistance, and thus anemia, in uremic patients. We evaluated the unknown long-term effects of L-carnitine admin...
The Way that PEGyl-DSPC Liposomal Doxorubicin Particles Penetrate into Solid Tumor Tissue [0.03%]
PEGyl-DSPC脂质包封多柔比星纳米粒穿透实体瘤组织的方式研究
Xing Qing Pan,Susie Jones,Karen Cox
Xing Qing Pan
Background: For enhancement of drug effectiveness and reduction of drug toxicity, liposomal drugs have been studied in laboratories and clinics for decades. Although the results obtained from in vitro are encouraging, but...
Modification of Monoaminergic Activity by MAO Inhibitors Influences Methamphetamine Actions [0.03%]
单胺氧化酶抑制剂对苯丙胺的作用的影响通过修改单胺能活性实现
Junichi Kitanaka,Nobue Kitanaka,Motohiko Takemura
Junichi Kitanaka
Methamphetamine (METH) abuse is a serious health and social problem worldwide. At present, however, there are no effective medications for the treatment of METH abuse. Of the intracellular METH target proteins, monoamine oxidase (MAO) is in...
Philippe Taupin
Philippe Taupin
The recent evidence that neurogenesis occurs throughout adulthood and neural stem cells (NSCs) reside in the adult central nervous system (CNS) suggests that the CNS has the potential for self-repair. Beside this potential, the function of ...
Thomas W Stief
Thomas W Stief
Background: The contact phase of coagulation is of physiologic/pathophysiologic importance, whenever unphysiologic polynegative substances such as cell fragments (microparticles) get in contact with blood. There are sever...
Philippe Taupin
Philippe Taupin
Alzheimer's disease (AD) is a neurodegenerative disease, characterized in the brain by amyloid plaque deposits and neurofibrillary tangles. It is the most common form of dementia among older people. There is at present no cure for AD, and c...