A Model for NAD(P)H:Quinoneoxidoreductase 1 (NQO1) Targeted Individualized Cancer Chemotherapy [0.03%]
一种针对NAD(P)H：广义辅酶Q氧化还原酶1（NQO1）的目标个体化癌症化疗模型
Asher Begleiter,Nadia El-Gabalawy,Laurie Lange et al.
Asher Begleiter et al.
NQO1 (NAD(P)H:quinoneoxidoreductase 1) is a reductive enzyme that is an important activator of bioreductive antitumor agents. NQO1 activity varies in individual tumors but is generally higher in tumor cells than in normal cells. NQO1 has be...
Effects of ascorbic Acid, alpha-tocopherol and allopurinol on ischemia-reperfusion injury in rabbit skeletal muscle: an experimental study [0.03%]
维生素C、维生素E和别嘌呤醇对兔骨骼肌缺血-再灌注损伤的保护作用：实验研究
Bilgehan Erkut,Ahmet Özyazıcıoğlu,Bekir Sami Karapolat et al.
Bilgehan Erkut et al.
Purpose: Ischemia reperfusion injury to skeletal muscle, following an acute arterial occlusion is important cause of morbidity and mortality. The aim of the present study was to determine and evaluate the effects of ascor...
Platelet-derived growth factor as a therapeutic target for systemic autoimmune diseases [0.03%]
血小板源性生长因子作为系统性自身免疫性疾病治疗靶点的研究进展
Hideto Kameda,Miyuki Suzuki,Tsutomu Takeuchi
Hideto Kameda
Some systemic rheumatic diseases and disorders, especially fibrotic and vascular disorders, are often refractory to corticosteroid therapy. Recently, ever accumulating evidence suggests that platelet-derived growth factor (PDGF) is involved...
Bodil Ohlsson,Sabina Janciauskiene
Bodil Ohlsson
Our understanding of the physiology of digestion, absorption, secretion, and motility in the gastrointestinal tract has improved immensely. Today it is well established that the gross functions of the gastrointestinal tract depend on the co...
Effect of live Salmonella Ty21a in dextran sulfate sodium-induced colitis [0.03%]
活Salmonella Ty21a在葡聚糖硫酸钠诱导的结肠炎中的作用
Gunnar Nysœter,Kari Erichsen,Anne Marita Milde et al.
Gunnar Nysœter et al.
Background: Intestinal microbiota seems to play an essential role in the development of inflammatory bowel diseases (IBD). We hypothesised that an oral vaccine based on live Salmonella typhi would be well tolerated and co...
Use and safety of anthroposophic medications for acute respiratory and ear infections: a prospective cohort study [0.03%]
人智学药物治疗急性呼吸道和耳部感染的使用及安全性：前瞻性队列研究
Harald J Hamre,Anja Glockmann,Michael Fischer et al.
Harald J Hamre et al.
Objective: Anthroposophic medications (AMED) are widely used, but safety data on AMED from large prospective studies are sparse. The objective of this analysis was to determine the frequency of adverse drug reactions (ADR...
N S Ningaraj,B P Salimath,U T Sankpal et al.
N S Ningaraj et al.
Brain tumor is associated with poor prognosis. The treatment option is severely limited for a patient with brain tumor, despite great advances in understanding the etiology and molecular biology of brain tumors that have lead to breakthroug...
R R Resende,H A M Torres,K K Yuahasi et al.
R R Resende et al.
The notorious biotechnological advance of the last few decades has allowed the development of experimental methods for understanding molecular mechanisms of genes and new therapeutic approaches. Gene therapy is maturing into a viable, pract...
Targeting human immunodeficiency virus type 1 assembly, maturation and budding [0.03%]
针对人类免疫缺陷病毒组装、成熟和出芽的抑制作用
Johanna Wapling,Seema Srivastava,Miranda Shehu-Xhilaga et al.
Johanna Wapling et al.
The targets for licensed drugs used for the treatment of human immunodeficiency virus type 1 (HIV-1) are confined to the viral reverse transcriptase (RT), protease (PR), and the gp41 transmembrane protein (TM). While currently approved drug...
Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications [0.03%]
用于皮肤病学领域的聚合物纳米颗粒、纳米球和纳米囊技术
Sílvia S Guterres,Marta P Alves,Adriana R Pohlmann
Sílvia S Guterres
This review presents an overview about pharmaceutical and cosmetic topical products containing polymeric nanoparticles (nanospheres and nanocapsules), reporting the main preparation and characterization methods and the studies of penetratio...