Effects of zaprinast and rolipram on olfactory and visual memory in the social transmission of food preference and novel object recognition tests in mice [0.03%]
扎普拉司特和罗利普拉姆对小鼠社交传递食物偏爱和社会新型物体识别试验中嗅觉和视觉记忆的影响
Furuzan Akar,Oguz Mutlu,Ipek K Celikyurt et al.
Furuzan Akar et al.
The role of phosphodiesterase (PDE) inhibitors in central nervous system has been investigated and shown to stimulate neuronal functions and increase neurogenesis in Alzheimer patients. The aim of this study is to investigate effect of PDE5...
The Antidepressant Agomelatine Improves Memory Deterioration and Upregulates CREB and BDNF Gene Expression Levels in Unpredictable Chronic Mild Stress (UCMS)-Exposed Mice [0.03%]
抗抑郁药物阿戈美拉汀改善不可预测慢性轻度应激小鼠记忆减退并上调CREB和BDNF基因表达水平
Esen Gumuslu,Oguz Mutlu,Deniz Sunnetci et al.
Esen Gumuslu et al.
Agomelatine, a novel antidepressant with established clinical efficacy, acts as an agonist of melatonergic MT1 and MT2 receptors and as an antagonist of 5-HT2C receptors. The present study was undertaken to investigate whether chronic treat...
In Silico Molecular Characterization of Cysteine Protease YopT from Yersinia pestis by Homology Modeling and Binding Site Identification [0.03%]
基于同源建模和结合位点鉴定的鼠疫耶尔森菌半胱氨酸蛋白酶YopT的分子模拟研究
Md Anayet Hasan,S M Alauddin,Mohammad Al Amin et al.
Md Anayet Hasan et al.
Plague is a major health concern and Yersinia pestis plays the central causal role in this disease. Yersinia pestis has developed resistance against the commonly available drugs. So, it is now a key concern to find a new drug target. Cystei...
Microscopic colitis and reproductive factors related to exposure to estrogens and progesterone [0.03%]
与接触雌激素和黄体酮相关的微结肠炎及生殖因素
Bodil Roth,Jonas Manjer,Bodil Ohlsson
Bodil Roth
Microscopic colitis (MC) often debuts around or after menopause and is divided into lymphocytic- and collagenous colitis. The aim of this study was to examine whether factors influencing sex hormone levels differed between subgroups of MC a...
Hsp60 chaperonin acts as barrier to pharmacologically induced oxidative stress mediated apoptosis in tumor cells with differential stress response [0.03%]
肿瘤细胞的热休克蛋白60在药物诱导的氧化应激介导的凋亡中的屏障作用及其不同应激反应机制的研究
Upasana Sarangi,Manish Kumar Singh,Kanugovi Vijaya Vittal Abhijnya et al.
Upasana Sarangi et al.
Mitochondrial functions play a central role in energy metabolism and provide survival fitness to both normal and tumor cells. Mitochondrial chaperonin Hsp60 is involved in both pro- and anti-apoptotic functions, but how Hsp60 senses the mit...
Md Lutful Amin
Md Lutful Amin
P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the body and is responsible for limiting cellular uptake and the distribution of xenobiotics and toxic substances. Hundreds of structurally diverse ther...
Bodil Roth,Jonas Manjer,Bodil Ohlsson
Bodil Roth
Microscopic colitis (MC) is a disease with intestinal mucosal inflammation causing diarrhea, affecting predominantly middle-aged women. The etiology is unknown, but increased prevalence of autoimmune diseases in these patients has been desc...
Impact of hepatocyte growth factor on skeletal myoblast transplantation late after myocardial infarction [0.03%]
肝细胞生长因子对心梗后骨骼肌前体细胞移植影响的研究
Stacy B O&#x;Blenes,Audrey W Li,Chris Bowen et al.
Stacy B O&#x;Blenes et al.
In clinical studies, skeletal myoblast (SKMB) transplantation late after myocardial infarction (MI) has minimal impact on left ventricular (LV) function. This may be related to our previous observation that the extent of SKMB engraftment is...
Antibodies against gonadotropin-releasing hormone in patients with posterior laryngitis [0.03%]
后喉炎患者的促性腺激素释放激素抗体
Hillevi Pendleton,Ragnar Alm,Gunilla Nordin Fredrikson et al.
Hillevi Pendleton et al.
Patients with functional gastrointestinal disorders express antibodies against gonadotropin-releasing hormone (GnRH) in serum. One common cause of posterior laryngitis (PL) is extra-esophageal reflux, but a functional etiology has also been...
Drug Target Exploitable Structural Features of Adenylyl Cyclase Activity in Schistosoma mansoni [0.03%]
活性腺苷酸环化酶在曼氏血吸虫中的药物靶标可利用的结构特征
Andreas N Mbah,Henri L Kamga,Omotayo R Awofolu et al.
Andreas N Mbah et al.
The draft genome sequence of the parasitic flatworm Schistosoma mansoni (S. mansoni), a cause of schistosomiasis, encodes a predicted guanosine triphosphate (GTP) binding protein tagged Smp_059340.1. Smp_059340.1 is predicted to be a member...