Genome-wide Analysis of Mycoplasma hominis for the Identification of Putative Therapeutic Targets [0.03%]
MGH基因组的全基因组分析以鉴定潜在治疗靶点
Md Masud Parvege,Monzilur Rahman,Mohammad Shahnoor Hossain
Md Masud Parvege
Ever increasing propensity of antibiotic resistance among pathogenic bacteria raises the demand for the development of novel therapeutic agents to control this grave problem. Advances in the field of bioinformatics, genomics, and proteomics...
The Expression of Serum Antibodies Against Gonadotropin-releasing Hormone (GnRH1), Progonadoliberin-2, Luteinizing Hormone (LH), and Related Receptors in Patients with Gastrointestinal Dysfunction or Diabetes Mellitus [0.03%]
胃肠功能障碍或糖尿病患者促性腺激素释放素(GnRH1)、促生殖素-2、黄体生成素(LH)及其相关受体的血清抗体表达式样研究
Bodil Roth,Kerstin Berntorp,Bodil Ohlsson
Bodil Roth
Gonadotropin-releasing hormone (GnRH) 1 and 2 and luteinizing hormone (LH) receptors have been described in the gastrointestinal tract. We have previously demonstrated antibodies in serum against GnRH1 in patients with gastrointestinal dysf...
Febuxostat for hyperuricemia in patients with advanced chronic kidney disease [0.03%]
慢性肾病晚期患者痛风及高尿酸血症的新疗法：febuxostat治疗
Tetsu Akimoto,Yoshiyuki Morishita,Chiharu Ito et al.
Tetsu Akimoto et al.
Febuxostat is a nonpurine xanthine oxidase (XO) inhibitor, which recently received marketing approval. However, information regarding the experience with this agent among advanced chronic kidney disease (CKD) patients is limited. In the cur...
Molecular and Kinetic Characterization of Babesia microti Gray Strain Lactate Dehydrogenase as a Potential Drug Target [0.03%]
巴贝斯虫灰株乳酸脱氢酶的分子和动力学表征作为潜在药物靶点的研究
Patrick Vudriko,Tatsunori Masatani,Shinuo Cao et al.
Patrick Vudriko et al.
Babesia microti is an emerging zoonotic protozoan organism that causes "malaria-like" symptoms that can be fatal in immunocompromised people. Owing to lack of specific therapeutic regiment against the disease, we cloned and characterized B....
Effects of zaprinast and rolipram on olfactory and visual memory in the social transmission of food preference and novel object recognition tests in mice [0.03%]
扎普拉司特和罗利普拉姆对小鼠社交传递食物偏爱和社会新型物体识别试验中嗅觉和视觉记忆的影响
Furuzan Akar,Oguz Mutlu,Ipek K Celikyurt et al.
Furuzan Akar et al.
The role of phosphodiesterase (PDE) inhibitors in central nervous system has been investigated and shown to stimulate neuronal functions and increase neurogenesis in Alzheimer patients. The aim of this study is to investigate effect of PDE5...
The Antidepressant Agomelatine Improves Memory Deterioration and Upregulates CREB and BDNF Gene Expression Levels in Unpredictable Chronic Mild Stress (UCMS)-Exposed Mice [0.03%]
抗抑郁药物阿戈美拉汀改善不可预测慢性轻度应激小鼠记忆减退并上调CREB和BDNF基因表达水平
Esen Gumuslu,Oguz Mutlu,Deniz Sunnetci et al.
Esen Gumuslu et al.
Agomelatine, a novel antidepressant with established clinical efficacy, acts as an agonist of melatonergic MT1 and MT2 receptors and as an antagonist of 5-HT2C receptors. The present study was undertaken to investigate whether chronic treat...
In Silico Molecular Characterization of Cysteine Protease YopT from Yersinia pestis by Homology Modeling and Binding Site Identification [0.03%]
基于同源建模和结合位点鉴定的鼠疫耶尔森菌半胱氨酸蛋白酶YopT的分子模拟研究
Md Anayet Hasan,S M Alauddin,Mohammad Al Amin et al.
Md Anayet Hasan et al.
Plague is a major health concern and Yersinia pestis plays the central causal role in this disease. Yersinia pestis has developed resistance against the commonly available drugs. So, it is now a key concern to find a new drug target. Cystei...
Microscopic colitis and reproductive factors related to exposure to estrogens and progesterone [0.03%]
与接触雌激素和黄体酮相关的微结肠炎及生殖因素
Bodil Roth,Jonas Manjer,Bodil Ohlsson
Bodil Roth
Microscopic colitis (MC) often debuts around or after menopause and is divided into lymphocytic- and collagenous colitis. The aim of this study was to examine whether factors influencing sex hormone levels differed between subgroups of MC a...
Hsp60 chaperonin acts as barrier to pharmacologically induced oxidative stress mediated apoptosis in tumor cells with differential stress response [0.03%]
肿瘤细胞的热休克蛋白60在药物诱导的氧化应激介导的凋亡中的屏障作用及其不同应激反应机制的研究
Upasana Sarangi,Manish Kumar Singh,Kanugovi Vijaya Vittal Abhijnya et al.
Upasana Sarangi et al.
Mitochondrial functions play a central role in energy metabolism and provide survival fitness to both normal and tumor cells. Mitochondrial chaperonin Hsp60 is involved in both pro- and anti-apoptotic functions, but how Hsp60 senses the mit...
Md Lutful Amin
Md Lutful Amin
P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the body and is responsible for limiting cellular uptake and the distribution of xenobiotics and toxic substances. Hundreds of structurally diverse ther...