Glycerophosphoinositol is Elevated in Blood Samples From CLN3 Δex7-8 pigs, Cln3 Δex7-8 Mice, and CLN3-Affected Individuals [0.03%]
CLN3 Δex7-8猪，Cln3 Δex7-8小鼠和CLN3病患者血液样本中的甘油磷肌醇升高
Jon J Brudvig,Vicki J Swier,Tyler B Johnson et al.
Jon J Brudvig et al.
Introduction: CLN3 Batten disease is a rare pediatric neurodegenerative lysosomal disorder caused by biallelic disease-associated variants in CLN3. Despite decades of intense research, specific biofluid biomarkers of dise...
Serum ACE2 Level is Associated With Severe SARS-CoV-2 Infection: A Cross-Sectional Observational Study [0.03%]
血清ACE2水平与严重SARS-CoV-2感染的关系：一项横断面观察研究
Amjad Bani Hani,Nafez Abu Tarboush,Mo&#x;ath Bani Ali et al.
Amjad Bani Hani et al.
Objectives: Angiotensin-converting enzyme 2 (ACE2) represents the primary receptor for SARS-CoV-2 to enter endothelial cells, causing coronavirus disease of 2019 (COVID-19). In this study, we investigate the association b...
Measuring Some Oxidative Stress Biomarkers in Autistic Syrian Children and Their Siblings: A Case-Control Study [0.03%]
测量氧化应激生物标志物在叙利亚自闭症儿童及其兄弟姐妹中的水平：一项病例对照研究
Oula Nasrallah,Samar Alzeer
Oula Nasrallah
Objective: Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder whose cause remains unknown. Oxidative stress is one of the possible causes of many disorders, including neurological ones. This study aims...
High Levels of the Carcinogenic Tobacco-Specific Nitrosamine NNAL and Associated Findings in Children of Smokers: A Case Series [0.03%]
吸烟者子女体内致癌烟草特异性亚硝胺NNAL含量偏高及其相关研究：一系列病例报告
E Melinda Mahabee-Gittens,Georg E Matt,Ashley L Merianos
E Melinda Mahabee-Gittens
High levels of NNAL, the tobacco smoke exposure (TSE) biomarker of the carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), indicate future cancer risk. A prior study of smokers' children revealed NNAL levels as high as active s...
Joint Modeling of Repeated Measurements of Different Biomarkers Predicts Mortality in COVID-19 Patients in the Intensive Care Unit [0.03%]
不同生物标志物的重复测量联合建模可预测ICU中COVID-19患者的死亡率
Kirby Tong-Minh,Yuri van der Does,Joost van Rosmalen et al.
Kirby Tong-Minh et al.
Introduction: Predicting disease severity is important for treatment decisions in patients with COVID-19 in the intensive care unit (ICU). Different biomarkers have been investigated in COVID-19 as predictor of mortality,...
Nephrotoxic Biomarkers with Specific Indications for Metallic Pollutants: Implications for Environmental Health [0.03%]
具有特定金属污染物指示性的肾毒性生物标志物对环境健康的意义
István Pócsi,Mark E Dockrell,Robert G Price
István Pócsi
Environmental and occupational exposure to heavy metals and metalloids is a major global health risk. The kidney is often a site of early damage. Nephrotoxicity is both a major consequence of heavy metal exposure and potentially an early wa...
The Role of Biomarkers in Hospitalized COVID-19 Patients With Systemic Manifestations [0.03%]
生物标志物在出现全身表现的住院COVID-19患者中的作用
Michael Schneider
Michael Schneider
The following article aims to review COVID-19 biomarkers used in hospital practice. It is apparent that COVID-19 is not simply a pulmonary disease but has systemic manifestations. For this reason, biomarkers must be used in the management o...
Elevated Levels of Pleiotropic Interleukin-6 (IL-6) and Interleukin-10 (IL-10) are Critically Involved With the Severity and Mortality of COVID-19: An Updated Longitudinal Meta-Analysis and Systematic Review on 147 Studies [0.03%]
多效性白细胞介素-6（IL-6）和白细胞介素-10（IL-10）水平升高与新冠肺炎严重程度及病死率密切相关：基于147项研究的纵向荟萃分析与系统评价更新结果
Sarah Jafrin,Md Abdul Aziz,Mohammad Safiqul Islam
Sarah Jafrin
Objectives: Disruption in the natural immune reaction due to SARS-CoV-2 infection can initiate a potent cytokine storm among COVID-19 patients. An elevated level of IL-6 and IL-10 during a hyperinflammatory state plays a ...
Progress Toward a Multiomic Understanding of Traumatic Brain Injury: A Review [0.03%]
多组学视角下的创伤性脑损伤研究进展综述
Philip A Kocheril,Shepard C Moore,Kiersten D Lenz et al.
Philip A Kocheril et al.
Traumatic brain injury (TBI) is not a single disease state but describes an array of conditions associated with insult or injury to the brain. While some individuals with TBI recover within a few days or months, others present with persiste...
Host Transcriptional Signatures Predict Etiology in Community-Acquired Pneumonia: Potential Antibiotic Stewardship Tools [0.03%]
宿主转录标志预测社区获得性肺炎的病原体：潜在的抗生素管理工具
William W Siljan,Dhanasekaran Sivakumaran,Christian Ritz et al.
William W Siljan et al.
Background: Current approaches for pathogen identification in community-acquired pneumonia (CAP) remain suboptimal, leaving most patients without a microbiological diagnosis. If better diagnostic tools were available for ...