Translating Liquid Biopsy into Practice- The Promise and Challenges of Circulating Tumor Cells in Ovarian and Lung Cancer Management [0.03%]
液体活检技术的临床实践之路——循环肿瘤细胞在卵巢癌及肺癌诊疗中的机遇与挑战
Nashrah Mustafa,Mehrin Haque Tanisha,Fariha Tasneem et al.
Nashrah Mustafa et al.
The increasing mortality from ovarian and lung cancers worldwide is largely due to late diagnosis and therapeutic resistance. Conventional biomarkers such as CA125 and CYFRA 21-1 lack the sensitivity or the specificity for monitoring real t...
Circulating EMID2 as a Prognostic Biomarker of Poor Outcomes in Patients with Metastatic Colorectal Cancer [0.03%]
循环EMID2蛋白作为转移性结直肠癌不良预后的生物标志物
Marina Crespo-Bravo,Sine R Syversen,Jeppe Thorlacius-Ussing et al.
Marina Crespo-Bravo et al.
Background: EMID1 and EMID2 (also known as type XXVI collagen) are extracellular matrix (ECM) proteins that belong to the EDEN gene superfamily. Both proteins feature EMI domains, implicating them in protein-protein inter...
Molecular Insights into the Regulatory Mechanisms Mediated by Hypoxia-Conditioned Skeletal Muscle Exosomal miRNAs [0.03%]
缺氧条件骨骼肌外泌体介导的miRNA调控机制的分子见解
Haijiao Wang,Baochang Shi,Wenting Song et al.
Haijiao Wang et al.
Background: Hypoxia alters skeletal muscle metabolism and function through complex regulatory mechanisms, including exosome-mediated microRNA (miRNA) signaling. ...
Galectin-3 Is Independently Associated With Short-Term Mortality and Identifies Low-Risk Patients With Acute Dyspnea in the Emergency Department: A Retrospective Cohort Study [0.03%]
甘露聚糖结合凝集素补体 lect2型受体3与短期死亡率的独立关联及其在急诊呼吸困难患者风险分层中的作用：回顾性队列研究
Ahmad Zwawi,Ardavan M Khoshnood,Ulf Ekelund et al.
Ahmad Zwawi et al.
Background: Dyspnea is a common and diagnostically challenging symptom in the emergency department (ED), particularly among older adults with multimorbidity. Traditional risk stratification tools often perform poorly in t...
Abnormal Serum Albumin, Alanine Aminotransferase, and Blood Urea Nitrogen are Associated with Higher Risks for Mechanical Ventilation and In-Hospital Mortality in COVID-19 Positive US Veterans [0.03%]
新冠肺炎阳性美国退伍军人血清白蛋白，丙氨酸氨基转移酶和血液尿素氮异常与机械通气和住院死亡率增高有关
Whitney D Moss,Giovanna R Pires,Guo Wei et al.
Whitney D Moss et al.
Background: Since the first reported case of Coronavirus Disease 2019 (COVID-19), clinicians and scientists have been challenged to contrive ideal prevention, detection, and treatment strategies. As the death toll surpass...
Salivary Proteomics & Gene Expression Analysis: Applications in Orthodontics and Oral Health Care Research-A Pilot Project [0.03%]
唾液蛋白质组及基因表达分析在口腔正畸和口腔健康护理研究中的应用-一个初步项目
Vaibhav Gandhi,Po-Jung Chen,Sumit Yadav
Vaibhav Gandhi
Background: Advances in analytical techniques, including salivary proteomics and gene expression analysis, have enabled the identification of thousands of proteins and specific genetic markers, providing a comprehensive u...
The Additional Prognostic Value of Serial Biomarker Measurements for Extubation Failure Among Patients With COVID-19 Acute Respiratory Distress Syndrome [0.03%]
新型冠状病毒肺炎急性呼吸窘迫综合征患者拔管失败的生物标志物指标动态预测价值研究
Carline N L Groenland,Adinde H Siemers,Eric A Dubois et al.
Carline N L Groenland et al.
Background: Extubation failure is associated with adverse outcomes in critically ill patients. While single biomarker measurements can aid prediction, repeated biomarker measurements can help to timely recognize underlyin...
Exploring Sex-Related Difference in Cerebrospinal Fluid/Blood Quotient of Albumin in Older Patients Undergoing Hip Fracture Surgery: Insight From the ORTODEL and BIODEL Study [0.03%]
基于ORTODEL和BIODEL研究的老年髋部骨折患者术中脑脊液/血清白蛋白商数性别差异的分析
Massimiliano Castellazzi,Maria Cristina Ferrara,Beatrice Arosio et al.
Massimiliano Castellazzi et al.
Background: The blood-cerebrospinal fluid barrier (BCSFB) regulates substance exchange between the blood and cerebrospinal fluid (CSF). Objectives: ...
Advancing Clinical Use of Neurofilament Light Chain: Translational Insights From Research to Routine Practice [0.03%]
神经丝轻链的临床应用进展：从研究到常规实践的转化见解
Evelina La Civita,Valerio Nicolella,Mariano Fiorenza et al.
Evelina La Civita et al.
Neurofilament Light Chain (NfL) has emerged as a promising biomarker for neurological diseases. NfL, a structural component of axons, is released into cerebrospinal fluid (CSF) and blood following neuro-axonal damage. Highly sensitive immun...
Extracellular Vesicle-Derived miRNAs as Diagnostic Biomarkers for Pancreatic Ductal Adenocarcinoma: A Systematic Review of Methodological Rigour and Clinical Applicability [0.03%]
外泌体来源的miRNA作为胰腺导管腺癌诊断生物标志物的方法学严谨性及临床适用性系统评价
Ryhan Divyang Patel,Bhavik Patel,Tatjana Crnogorac-Jurcevic
Ryhan Divyang Patel
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with currently limited early detection options. Extracellular vesicle (EV)-derived microRNAs (miRNAs) have gained interest as non-invasive ...