Antonis A Manolis,Theodora A Manolis,Dimitri P Mikhailidis et al.
Antonis A Manolis et al.
Lipid-lowering therapies, particularly non-statin regimens, are underutilized as ~2/3 of patients with atherosclerotic cardiovascular (CV) disease (CVD) are not optimally managed, and do not attain target low-density lipoprotein cholesterol...
The Evolving Landscape of Biomarkers for Immune Checkpoint Blockade in Genitourinary Cancers [0.03%]
免疫检查点抑制在泌尿生殖系统肿瘤生物标志物中的演变景观
Seema Mustafa,Caroline S Jansen,Yash Jani et al.
Seema Mustafa et al.
In the past decade, immune checkpoint inhibitors (ICI) have been approved for treatment of genitourinary malignancies and have revolutionized the treatment landscape of these tumors. However, despite the remarkable success of these therapie...
Comparative Analysis of Biomarkers in Type 2 Diabetes Patients With and Without Comorbidities: Insights Into the Role of Hypertension and Cardiovascular Disease [0.03%]
伴与不伴并发症的2型糖尿病患者生物标志物比较分析：高血压和心血管疾病作用机制的新见解
Symeon Savvopoulos,Haralampos Hatzikirou,Herbert F Jelinek
Symeon Savvopoulos
Background: Type 2 diabetes mellitus (T2DM) are 90% of diabetes cases, and its prevalence and incidence, including comorbidities, are rising worldwide. Clinically, diabetes and associated comorbidities are identified by b...
Evaluating the Role of Methylated Circulating Tumor DNA in Combination With Pathological Prognostic Factors for Predicting Recurrence of Colorectal Cancer [0.03%]
甲基化循环肿瘤DNA联合病理预后因素在预测结直肠癌复发中的作用评估
Hiba Al Naji,Jean M Winter,Susanne K Pedersen et al.
Hiba Al Naji et al.
Background: Colorectal cancer (CRC) has a high rate of recurrence, in particular for advanced disease, but prognosis based on staging and pathology at surgery can have limited efficacy. The presence of circulating tumor D...
mRNA Expression and Methylation of the RAD51, ATM, ATR, BRCA1, and BRCA2 Genes in Gastric Adenocarcinoma [0.03%]
胃腺癌中RAD51、ATM、ATR、BRCA1和BRCA2基因的mRNA表达及甲基化情况研究
Joel Del Bel Pádua,Carolline Fontes Alves Mariano,Alexandre Todorovic Fabro et al.
Joel Del Bel Pádua et al.
Background: Immunohistochemical prognostic significance of the homologous recombination-related proteins RAD51, ATM, BRCA1, and BRCA2 is known in gastric adenocarcinoma, one of the deadliest cancers. ...
Prognostic Value of Neutrophils-to-Lymphocytes Ratio and Platelets-to-Lymphocytes Ratio in Sepsis Patients With Lymphopenia [0.03%]
中性粒细胞淋巴细胞比率和血小板淋巴细胞比率在淋巴细胞减少症脓毒症患者中的预后价值
Xianming Qiu,Quanzhen Wang,Yuke Zhang et al.
Xianming Qiu et al.
Background: Inflammation plays a critical role in sepsis. The integration of neutrophil-to-lymphocyte ratio (NLR) and platelets-to-lymphocytes ratio (PLR) from multiple cell types offers a novel approach to rapidly assess...
Detection of Inflammatory Biomarker suPAR in COVID-19 Disease With CHORUS TRIO Instrument [0.03%]
使用CHORUS TRIO仪器检测COVID-19疾病中的炎症生物标志物suPAR
Cerutti Helena,Tesi Giulia,Cartocci Alessandra et al.
Cerutti Helena et al.
Background: Deregulation in the urokinase-type plasminogen activator receptor (uPA/uPAR) system is reported in many diseases where the immune system is activated. During SARS-CoV-2 infection, a rise in soluble uPAR (suPAR...
Multiomic Approaches for Cancer Biomarker Discovery in Liquid Biopsies: Advances and Challenges [0.03%]
液体活检中用于癌症生物标志物发现的多组学方法：进展与挑战
Paola Monterroso Diaz,Ashton Leehans,Prashanth Ravishankar et al.
Paola Monterroso Diaz et al.
Cancer is a complex and heterogeneous disease that poses a significant threat to global health. Early diagnosis and treatment are critical for improving patient outcomes, and the use of liquid biopsies has emerged as a promising approach fo...
The Latest Developments in Using Proteomic Biomarkers from Urine and Serum for Non-Invasive Disease Diagnosis and Prognosis [0.03%]
基于尿液和血清的蛋白质组生物标志物的最新进展及其在非侵入性疾病诊断和预后中的应用
Anurag Shama,Thomson Soni,Ishwerpreet Kaur Jawanda et al.
Anurag Shama et al.
Due to diagnostic improvements, medical diagnostics is demanding non-invasive or minimally invasive methods. Non-invasively obtained body fluids (eg., Urine, serum) can replace cerebral fluid, amniotic fluid, synovial fluid, bronchoalveolar...
Implementation of a Customized Tertiary Analysis Platform for the Reporting of Somatic Variants [0.03%]
一种用于报告体细胞变异的定制三级分析平台的实现
Kala F Schilter,Sarah Dubay,Matt Stachowiak et al.
Kala F Schilter et al.
Precision medicine for oncology requires the evaluation of variants identified in molecular profiling of solid tumors and hematologic malignancies. This includes evaluation of pre-analytical and postanalytical quality metrics, variant inter...