Joint Modeling of Repeated Measurements of Different Biomarkers Predicts Mortality in COVID-19 Patients in the Intensive Care Unit [0.03%]
不同生物标志物的重复测量联合建模可预测ICU中COVID-19患者的死亡率
Kirby Tong-Minh,Yuri van der Does,Joost van Rosmalen et al.
Kirby Tong-Minh et al.
Introduction: Predicting disease severity is important for treatment decisions in patients with COVID-19 in the intensive care unit (ICU). Different biomarkers have been investigated in COVID-19 as predictor of mortality,...
Nephrotoxic Biomarkers with Specific Indications for Metallic Pollutants: Implications for Environmental Health [0.03%]
具有特定金属污染物指示性的肾毒性生物标志物对环境健康的意义
István Pócsi,Mark E Dockrell,Robert G Price
István Pócsi
Environmental and occupational exposure to heavy metals and metalloids is a major global health risk. The kidney is often a site of early damage. Nephrotoxicity is both a major consequence of heavy metal exposure and potentially an early wa...
The Role of Biomarkers in Hospitalized COVID-19 Patients With Systemic Manifestations [0.03%]
生物标志物在出现全身表现的住院COVID-19患者中的作用
Michael Schneider
Michael Schneider
The following article aims to review COVID-19 biomarkers used in hospital practice. It is apparent that COVID-19 is not simply a pulmonary disease but has systemic manifestations. For this reason, biomarkers must be used in the management o...
Elevated Levels of Pleiotropic Interleukin-6 (IL-6) and Interleukin-10 (IL-10) are Critically Involved With the Severity and Mortality of COVID-19: An Updated Longitudinal Meta-Analysis and Systematic Review on 147 Studies [0.03%]
多效性白细胞介素-6（IL-6）和白细胞介素-10（IL-10）水平升高与新冠肺炎严重程度及病死率密切相关：基于147项研究的纵向荟萃分析与系统评价更新结果
Sarah Jafrin,Md Abdul Aziz,Mohammad Safiqul Islam
Sarah Jafrin
Objectives: Disruption in the natural immune reaction due to SARS-CoV-2 infection can initiate a potent cytokine storm among COVID-19 patients. An elevated level of IL-6 and IL-10 during a hyperinflammatory state plays a ...
Progress Toward a Multiomic Understanding of Traumatic Brain Injury: A Review [0.03%]
多组学视角下的创伤性脑损伤研究进展综述
Philip A Kocheril,Shepard C Moore,Kiersten D Lenz et al.
Philip A Kocheril et al.
Traumatic brain injury (TBI) is not a single disease state but describes an array of conditions associated with insult or injury to the brain. While some individuals with TBI recover within a few days or months, others present with persiste...
Host Transcriptional Signatures Predict Etiology in Community-Acquired Pneumonia: Potential Antibiotic Stewardship Tools [0.03%]
宿主转录标志预测社区获得性肺炎的病原体：潜在的抗生素管理工具
William W Siljan,Dhanasekaran Sivakumaran,Christian Ritz et al.
William W Siljan et al.
Background: Current approaches for pathogen identification in community-acquired pneumonia (CAP) remain suboptimal, leaving most patients without a microbiological diagnosis. If better diagnostic tools were available for ...
Volatile Organic Compounds Analysis as a Potential Novel Screening Tool for Breast Cancer: A Systematic Review [0.03%]
挥发性有机化合物分析作为乳腺癌潜在新型筛查工具的系统评价
Michelle Leemans,Pierre Bauër,Vincent Cuzuel et al.
Michelle Leemans et al.
Introduction: An early diagnosis is crucial in reducing mortality among people who have breast cancer (BC). There is a shortfall of characteristic early clinical symptoms in BC patients, highlighting the importance of inv...
Identification of Potential Urinary Metabolite Biomarkers of Pseudomonas aeruginosa Ventilator-Associated Pneumonia [0.03%]
铜绿假单胞菌呼吸机相关性肺炎潜在尿液代谢物生物标志物的鉴定
Bart&#x;s Jongers,An Hotterbeekx,Kenny Bielen et al.
Bart&#x;s Jongers et al.
Introduction: Ventilator-associated pneumonia (VAP) caused by Pseudomonas aeruginosa is a major cause of morbidity and mortality in hospital intensive care units (ICU). Rapid identification of P. aeruginosa-derived marker...
Cytokines in Abdominal Aortic Aneurysm: Master Regulators With Clinical Application [0.03%]
腹主动脉瘤中的细胞因子：具有临床应用价值的调控大师
Olesya A Puchenkova,Vladislav O Soldatov,Andrei E Belykh et al.
Olesya A Puchenkova et al.
Abdominal aortic aneurysm (AAA) is a potentially life-threatening disorder with a mostly asymptomatic course where the abdominal aorta is weakened and bulged. Cytokines play especially important roles (both positive and negative) among the ...
Tamsin E Tarling,Jennifer A Byrne,Peter H Watson
Tamsin E Tarling
Preserved biospecimens held in biobank inventories and clinical archives are important resources for biomarker research. Recent advances in technologies have led to an increase in use of clinical archives in particular, in order to study re...