Stefan Stefanov,James Lautenberger,Bert Gold
Stefan Stefanov
We developed an efficient pipeline to analyze genome-wide association study single nucleotide polymorphism scan results. Purl scripts were used to convert genotypes called using the BRLMM algorithm into a modified PB format. We computed sum...
Decentralized data sharing of tissue microarrays for investigative research in oncology [0.03%]
用于肿瘤学调查研究的组织微列阵去中心化数据共享
Wenjin Chen,Cristina Schmidt,Manish Parashar et al.
Wenjin Chen et al.
Tissue microarray technology (TMA) is a relatively new approach for efficiently and economically assessing protein and gene expression across large ensembles of tissue specimens. Tissue microarray technology holds great potential for reduci...
Statistical issues and analyses of in vivo and in vitro genomic data in order to identify clinically relevant profiles [0.03%]
统计问题及体内和体外基因组数据分析以识别临床相关信息配置文件的问题与分析
Laila M Poisson,Debashis Ghosh
Laila M Poisson
In vitro experimentation provides a convenient controlled environment for testing biological hypotheses of functional genomics in cancer induction and progression. However, it is necessary to validate resulting gene signatures from these in...
Classifying Variants of Undetermined Significance in BRCA2 with protein likelihood ratios [0.03%]
采用蛋白预测概率比值法对BRCA2基因变异意义不明的变异进行分类的研究
Rachel Karchin,Mukesh Agarwal,Andrej Sali et al.
Rachel Karchin et al.
Background: Missense (amino-acid changing) variants found in cancer predisposition genes often create difficulties when clinically interpreting genetic testing results. Although bioinformatics has developed approaches to ...
Effect of quantitative nuclear image features on recurrence of Ductal Carcinoma In Situ (DCIS) of the breast [0.03%]
定量核图像特征对乳腺导管原位癌(DCIS)复发的影响
David E Axelrod,Naomi A Miller,H Lavina Lickley et al.
David E Axelrod et al.
Background: Nuclear grade has been associated with breast DCIS recurrence and progression to invasive carcinoma; however, our previous study of a cohort of patients with breast DCIS did not find such an association with o...
A computational model of quantitative chromatin immunoprecipitation (ChIP) analysis [0.03%]
定量染色质免疫沉淀分析的计算模型
Jingping Xie,Philip S Crooke,Brett A McKinney et al.
Jingping Xie et al.
Chromatin immunoprecipitation (ChIP) analysis is widely used to identify the locations in genomes occupied by transcription factors (TFs). The approach involves chemical cross-linking of DNA with associated proteins, fragmentation of chroma...
Investigation of miRNA biology by bioinformatic tools and impact of miRNAs in colorectal cancer--regulatory relationship of c-Myc and p53 with miRNAs [0.03%]
生物信息学工具研究微小核糖核酸的生物学并探讨微小核糖核酸对结直肠癌的影响及c-Myc和p53与微小核糖核酸的调控关系
Yaguang Xi,John R Edwards,Jingfang Ju
Yaguang Xi
MicroRNAs (miRNAs) are a class of small non-coding RNAs that mediate gene expression at the posttranscriptional and translational levels and have been demonstrated to be involved in diverse biological functions. Mounting evidence in recent ...
Computational methods for the analysis of array comparative genomic hybridization [0.03%]
阵列 Comparative Genomic Hybridization 分析的计算方法
Raj Chari,William W Lockwood,Wan L Lam
Raj Chari
Array comparative genomic hybridization (array CGH) is a technique for assaying the copy number status of cancer genomes. The widespread use of this technology has lead to a rapid accumulation of high throughput data, which in turn has prom...
Ganesh Shankar,Michael R Rossi,Devin E McQuaid et al.
Ganesh Shankar et al.
Array-Comparative Genomic Hybridization (aCGH) is a powerful high throughput technology for detecting chromosomal copy number aberrations (CNAs) in cancer, aiming at identifying related critical genes from the affected genomic regions. Howe...
An Immunogenic Cell Death-Related Gene Signature Predicts the Prognosis and Immune Infiltration of Cervical Cancer [0.03%]
与免疫原性细胞死亡相关的基因特征可预测宫颈癌的预后和免疫浸润情况
Objectives: Immunogenic cell death (ICD) has been demonstrated to play a critical role in the development and progression of malignant tumors by modulating the anti-tumor immune response. However, its function in cervical...