Integrative Analyses of Individual Patient Genomic-Data to Discover Novel Biomarkers: Application to Cervical Pre-Cancer DNA-Methylation Datasets [0.03%]
对个体患者基因组数据的综合分析以发现新型生物标志物：应用于宫颈癌前DNA甲基化数据集
Innas Widiasti,Putri Wikie Novianti
Innas Widiasti
Objective: The growing availability of public genomic repositories led to increased use of integrative and meta-analytic approaches to combine multi-omics datasets for biomarker discovery. Building on this framework, our ...
The Multitalented Marvels: Exploring the Versatile Potential of Natural Products in Osteosarcoma Treatment [0.03%]
多才多艺的奇迹：探索天然产物在骨肉瘤治疗中 versatile potential 的广泛应用潜力
Chenxu Jia,Qingtao Meng,Mingna Huo et al.
Chenxu Jia et al.
Osteosarcoma (OS) is a malignant neoplasm arising from bone tissue. The OS exhibited a significant degree of heterogeneity, with a high incidence of local invasion and a high rate of metastasis. Approximately 25% of those diagnosed with OS ...
The Association of Neutrophil-To-Lymphocyte and Platelet-To-Lymphocyte Ratios With Distant Metastasis in Vietnamese Gastric Cancer Patients [0.03%]
中性粒细胞与淋巴细胞及血小板与淋巴细胞比值与越南胃癌患者远处转移的关系研究
N Tran,D N L Tran,T H D Phan et al.
N Tran et al.
Background: Gastric cancer (GC) remains a leading cause of mortality in Vietnam, where distant metastasis is frequently present at diagnosis. Since accessible biomarkers are scarce, we evaluated the association of Neutrop...
Clostridium-Derived p-Cresyl Metabolites Induce Inflammation and Apoptosis in Biliary Epithelial Cells [0.03%]
胆汁酸促进肠道菌群中产生对肝脏有害的代谢物
Haiyan Yu,Haiyan Fu,Jiamin Xu et al.
Haiyan Yu et al.
Objective: Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease, and the effects of p-cresyl sulfate (PCS) and p-cresyl glucuronide (PCG) in PBC remain unclear. This study aimed to evaluate the pro...
Trends and Disparities in Mortality from Malignant Parotid Gland Tumors in the United States, 1999-2023: A Population-Based Analysis [0.03%]
1999-2023年美国恶性腮腺肿瘤死亡率的流行趋势及不平等现象：基于人口的分析研究
Qianqian Xu,Sunjun Li,Fangyuan Liao et al.
Qianqian Xu et al.
Introduction: Malignant parotid gland tumors account for less than 1% of all cancers yet represent a substantial proportion of head and neck malignancies. Long-term mortality trends and demographic disparities remain poor...
Development and Validation of a Six-Gene Signature of Myeloid Antigen Presentation Dysfunction Based on Single-Cell and Multi-Cohort Transcriptomics for Predicting Prognosis and Recurrence of Hepatocellular Carcinoma [0.03%]
基于单细胞和多队列转录组学的六基因特征在预测肝癌患者预后及复发中的开发与验证：髓系抗原呈递功能障碍相关标志物研究
Ye Tan,Jingxuan Xiang,Zehan Wang et al.
Ye Tan et al.
Background: Myeloid antigen-presentation dysfunction is a central but incompletely translated immune state in hepatocellular carcinoma (HCC). This study aimed to develop a compact prognostic and recurrence model directly ...
Widening Health Inequality and Causal Metabolic Drivers in Global Colorectal Cancer: A Multi-Dimensional Study [0.03%]
全球结直肠癌的健康不平等加剧及其因果代谢驱动因素：一项多维度研究
Song Gao,Mingying Peng,Susu Han et al.
Song Gao et al.
Objectives: To describe the geographical distribution of global colorectal cancer (CRC) and the time trend of its disease burden from 1990 to 2021, and to predict its future development. ...
GFAP-Dependent Transcriptional Dynamics and Cellular Heterogeneity in Primary, Recurrent, and Grade III Gliomas [0.03%]
以GFAP依赖性转录动力学和细胞异质性为主的原发、复发及三级胶质瘤的研究
Morteza Hadizadeh,Seyedeh Zahra Mousavi,Sorayya Ghasemi
Morteza Hadizadeh
Objectives: Glioma tumors, especially glioblastoma (GBM), are among the most heterogeneous brain cancers, and this characteristic is considered the main cause of treatment resistance and disease recurrence. The aim of thi...
Translating Data Into Clinical Tools: An Integrative Strategy for Precision Biomarker Identification in Soft Tissue Sarcoma Diagnosis and Prognosis [0.03%]
数据向临床工具转化：软组织肉瘤诊断和预后精确诊断标志物识别的集成策略
Masoume Avateffazeli,Rahem Rahmati,Abdolreza Mohammadnia et al.
Masoume Avateffazeli et al.
Objectives: Soft tissue sarcomas (STSs) are rare, heterogeneous cancers with over 70 subtypes, often diagnosed late due to diagnostic complexity, leading to poor outcomes. We aimed to identify and validate novel transcrip...
The MAPK Pathway Coordinates an Immunosuppressive Microenvironment in Colorectal Cancer: A Single-Cell Guided Prognostic Model [0.03%]
单细胞指导的预后模型揭示MAPK信号途径在结直肠癌中塑造免疫抑制微环境的作用
Yao Zhang,Xizheng Zhang,Jiayu Wei et al.
Yao Zhang et al.
Background: The immunosuppressive tumor microenvironment in colorectal cancer is a key factor in its progression and treatment resistance, yet the coordinated mechanisms of its cellular composition and signaling networks ...