Machine Learning Approach and Bioinformatics Analysis Discovered Key Genomic Signatures for Hepatitis B Virus-Associated Hepatocyte Remodeling and Hepatocellular Carcinoma [0.03%]
机器学习方法和生物信息学分析发现乙型肝炎病毒相关肝细胞重塑及肝癌关键基因标志物
Adane Adugna,Gashaw Azanaw Amare,Mohammed Jemal
Adane Adugna
Hepatitis B virus (HBV) causes liver cancer, which is the third most common cause of cancer-related death worldwide. Chronic inflammation via HBV in the host hepatocytes causes hepatocyte remodeling (hepatocyte transformation and immortaliz...
DNA Methylation Biomarker Discovery for Colorectal Cancer Diagnosis Assistance Through Integrated Analysis [0.03%]
通过综合分析用于结直肠癌辅助诊断的DNA甲基化生物标志物发现
Yi-Hsuan Tsai,Yi-Husan Lai,Shu-Jen Chen et al.
Yi-Hsuan Tsai et al.
Objective: This study aimed to identify biomarkers for colorectal cancer (CRC) with representative gene functions and high classification accuracy in tissue and blood samples. ...
Twenty Year History of Cancer Informatics (CiX) - A Long and Established Legacy of Quality Research and Scientific Advances in the Field of Oncology [0.03%]
癌症信息学(CiX)二十年的历史-肿瘤学领域高质量研究和科学进展的悠久而悠久的传统
Jimmy T Efird
Jimmy T Efird
Over a 20 year period, the journal Cancer Informatics has played an important role defining and forging a bridge between bioinformations and translational cancer research. The main focus of the journal has been to advance the prevention, di...
Single-cell Analysis Highlights Anti-apoptotic Subpopulation Promoting Malignant Progression and Predicting Prognosis in Bladder Cancer [0.03%]
单细胞分析揭示了促进膀胱癌恶性进展和预测预后的抗凋亡亚群
Linhuan Chen,Yangyang Hao,Tianzhang Zhai et al.
Linhuan Chen et al.
Backgrounds: Bladder cancer (BLCA) has a high degree of intratumor heterogeneity, which significantly affects patient prognosis. We performed single-cell analysis of BLCA tumors and organoids to elucidate the underlying m...
Integrated Bioinformatic Analyses Reveal Thioredoxin as a Putative Marker of Cancer Stem Cells and Prognosis in Prostate Cancer [0.03%]
综合生物信息学分析揭示硫氧还蛋白可能是前列腺癌癌症干细胞和预后潜在标志物
Shigeru Sugiki,Tetsuhiro Horie,Kenshiro Kunii et al.
Shigeru Sugiki et al.
Objectives: Prostate cancer stem cells (CSCs) play an important role in cancer cell survival, proliferation, metastasis, and recurrence; thus, removing CSCs is important for complete cancer removal. However, the mechanism...
Identification of Molecular Subtypes and Prognostic Features of Breast Cancer Based on TGF-β Signaling-related Genes [0.03%]
基于TGF-β信号相关基因的乳腺癌分子亚型和预后特征识别
Jia Qu,Mei-Huan Wang,Yue-Hua Gao et al.
Jia Qu et al.
Objectives: The TGF-β signaling pathway is widely acknowledged for its role in various aspects of cancer progression, including cellular invasion, epithelial-mesenchymal transition, and immunosuppression. Immune checkpoi...
Utilizing an In-silico Approach to Pinpoint Potential Biomarkers for Enhanced Early Detection of Colorectal Cancer [0.03%]
利用计算机模拟方法寻找结直肠癌早期检测潜在生物标志物
Alireza Gharebaghi,Saeid Afshar,Leili Tapak et al.
Alireza Gharebaghi et al.
Objectives: Colorectal cancer (CRC) is a prevalent disease characterized by significant dysregulation of gene expression. Non-invasive tests that utilize microRNAs (miRNAs) have shown promise for early CRC detection. This...
Cathepsin L in Lung Adenocarcinoma: Prognostic Significance and Immunotherapy Response Through a Multi Omics Perspective [0.03%]
肺癌腺癌组织中Cathepsin L的表达及其预后价值和免疫治疗反应的多组学研究
Jianming Lu,Jiaqi Liang,Gang Xiao et al.
Jianming Lu et al.
Objectives: Lung adenocarcinoma (LUAD), a predominant form of lung cancer, is characterized by a high rate of metastasis and recurrence, leading to a poor prognosis for LUAD patients. This study aimed to identify and rigo...
Detecting the Tumor Prognostic Factors From the YTH Domain Family Through Integrative Pan-Cancer Analysis [0.03%]
基于泛癌分析的YTH结构域家族肿瘤预后因子识别研究
Chong-Ying Zhu,Qi-Wei Yang,Xin-Yue Mu et al.
Chong-Ying Zhu et al.
Objectives: Emerging evidence suggests that N6-methyladenosine (m6A) methylation plays a critical role in cancers through various mechanisms. This work aims to reveal the essential role of m6A methylation "readers" in reg...
Unveiling Recurrence Patterns: Analyzing Predictive Risk Factors for Breast Cancer Recurrence after Surgery [0.03%]
揭示复发模式：手术后乳腺癌复发的预测风险因素分析
Monireh Shahmoradi,Ahmad Fazilat,Mostafa Ghaderi-Zefrehei et al.
Monireh Shahmoradi et al.
Objectives: Breast cancer (BC) stands as the second-leading cause of female-specific cancer-related fatalities globally, necessitating comprehensive research to address its critical aspects. This study aimed to explore th...