Distribution, Phylogeny and Evolution of Clinical and Environmental Vibrio vulnificus Antibiotic-Resistant Genes [0.03%]
临床和环境中的副溶血弧菌的耐药基因的分布、系统发育及进化研究
Nan Geng,Guojin Sun,Wen-Jia Liu et al.
Nan Geng et al.
Vibrio vulnificus is an emergent marine pathogen and is the cause of a deadly septicemia. However, the evolution mechanism of antibiotic-resistant genes (ARGs) is still unclear. Twenty-two high-quality complete genomes of V. vulnificus were...
Bioinformatics-based Characterization of the Sequence Variability of Zika Virus Polyprotein and Envelope Protein (E) [0.03%]
基于生物信息学的寨卡病毒多蛋白和包膜蛋白(E)序列变异特征分析
Carlos Polanco,Vladimir N Uversky,Alberto Huberman et al.
Carlos Polanco et al.
Background: Zika virus, which is widely spread and infects humans through the bites of Aedes albopictus and Aedes aegypti female mosquitoes, represents a serious global health issue. ...
Integrated Analysis of Multi-Omics Data to Establish a Hypoxia-Related Prognostic Model in Osteosarcoma [0.03%]
整合多组学数据建立骨肉瘤低氧相关预后模型的综合分析
Ye Tong,Xiaoqing Zhang,Ye Zhou
Ye Tong
Background: Osteosarcoma (OS) is the most common malignant bone tumor in clinical practice, and currently, the ability to predict prognosis in the diagnosis of OS is limited. There is an urgent need to find new diagnostic...
Stability of scRNA-Seq Analysis Workflows is Susceptible to Preprocessing and is Mitigated by Regularized or Supervised Approaches [0.03%]
预处理会影响scRNA-seq分析流程的稳定性，可通过正则化或监督学习方法缓解该问题
Arda Durmaz,Jacob G Scott
Arda Durmaz
Background: Statistical methods developed to address various questions in single-cell datasets show increased variability to different parameter regimes. In order to delineate further the robustness of commonly utilized m...
Construction of a Prognostic Nomogram Based on Autophagy-Related Genes for Children With Neuroblastoma [0.03%]
基于自噬相关基因的儿童神经母细胞瘤预后 nomogram 的构建
Guogang Ye,Yue Wang
Guogang Ye
Neuroblastoma (NB) is the most common solid malignancy in children. MYCN gene amplification is the most relevant genetic alteration in patients with NB and is associated with poor prognosis. Autophagy plays specific roles in the occurrence,...
Transcriptomics of a Greenlandic Snailfish Reveals Exceptionally High Expression of Antifreeze Protein Transcripts [0.03%]
格陵兰深海鱼转录组测序揭示其高表达抗冻蛋白 transcriptomes
John A Burns,David F Gruber,Jean P Gaffney et al.
John A Burns et al.
Polar fishes have evolved antifreeze proteins (AFPs) that allow them to survive in subzero temperatures. We performed deep transcriptomic sequencing on a postlarval/juvenile variegated snailfish, Liparis gibbus (Actinopterygii: Scorpaenifor...
Bioinformatics Analysis Identifies Potential Related Genes in the Pathogenesis of Intrauterine Fetal Growth Retardation [0.03%]
生物信息学分析鉴定出宫内胎儿生长受限发病相关的潜在基因
Chao Xiao,Yao Wang,Yuchao Fan
Chao Xiao
Background: Intrauterine growth retardation (IUGR) affects approximately 10% to 15% of all pregnancies worldwide. IUGR is not only associated with stillbirth and newborn death, but also the delay of cognition in childhood...
Computational Structural and Functional Analyses of ORF10 in Novel Coronavirus SARS-CoV-2 Variants to Understand Evolutionary Dynamics [0.03%]
新型冠状病毒SARS-CoV-2变异株ORF10的生物信息学结构与功能分析及其进化动力学研究
Seema Mishra
Seema Mishra
Introduction: In an effort to combat SARS-CoV-2 through multi-subunit vaccine design, during studies using whole genome and immunome, ORF10, located at the 3' end of the genome, displayed unique features. It showed no hom...
Analysis of Competitive Endogenous RNA Regulatory Network of Exosomal Breast Cancer Based on exoRBase [0.03%]
基于exoRBase的乳腺癌外泌体竞争内源性RNA调控网络分析
Kangle Zhu,Qingqing Wang,Lian Wang
Kangle Zhu
Objective: To construct a competitive endogenous RNA (ceRNA) regulatory network derived from exosomes of human breast cancer (BC) by using the exoRbase database, to explore the possible pathogenesis of BC, and to develop ...
Umair Ayub,Hammad Naveed
Umair Ayub
Motivation: The advancement of high-throughput PPI profiling techniques results in generating a large amount of PPI data. The alignment of the PPI networks uncovers the relationship between the species that can help under...