Structural and Functional Characterization of a Putative Type VI Secretion System Protein in Cronobacter sakazakii as a Potential Therapeutic Target: A Computational Study [0.03%]
计算研究：肠杆菌素萨克扎基辅菌潜在的治疗靶标六型分泌系统假定蛋白的结构和功能表征
Nurun Nahar Akter,Md Moin Uddin,Nesar Uddin et al.
Nurun Nahar Akter et al.
Background: Cronobacter sakazakii, a foodborne pathogen with a fatality rate of 33%, is a rod-shaped, Gram-negative, non-spore-forming bacterium responsible for causing meningitis, bacteremia, and necrotizing enterocoliti...
Genome-Wide Identification and Characterization of the WRKY Gene Family and Their Associated Regulatory Elements in Fortunella hindsii [0.03%]
香圆中WRKY基因家族的全基因组鉴定与特征分析及其相关调控元件分析
Hadia Hussain,Aleena Alam,Iqra Mehar et al.
Hadia Hussain et al.
Background: The WRKY gene family is identified as one of the most prominent transcription factor families in plants and is involved in various biological processes such as metabolism, growth and development, and response ...
Phylodynamic Investigation of Yellow Fever Virus Sheds New Insight on Geographic Dispersal Across Africa [0.03%]
黄热病毒的谱系动态研究揭示了其在非洲大陆传播的新见解
Babatunde Olanrewaju Motayo,Adewale Opayele,Paul Akiniyi Akinduti et al.
Babatunde Olanrewaju Motayo et al.
Background: Molecular epidemiology has shown the presence of four genotypes circulating across Africa, a paucity of data exists regarding phylogeography of the African Yellow fever (YF) genotypes. The need to fill this ga...
In silico Characterization of a Hypothetical Protein (PBJ89160.1) from Neisseria meningitidis Exhibits a New Insight on Nutritional Virulence and Molecular Docking to Uncover a Therapeutic Target [0.03%]
链球菌属脑膜炎奈瑟菌中的假想蛋白(PBJ89160.1)的计算机表征为营养致病性提供了新的见解以及分子对接以发现治疗靶点
Israt Jahan Asha,Shipan Das Gupta,Md Murad Hossain et al.
Israt Jahan Asha et al.
Objective: Neisseria meningitidis is an encapsulated, diplococcus, kidney bean-shaped bacteria that causes bacterial meningitis. Our study hopes to advance our understanding of disease progression, the spread frequency of...
Comparative Phylogenetic Analysis and Protein Prediction Reveal the Taxonomy and Diverse Distribution of Virulence Factors in Foodborne Clostridium Strains [0.03%]
比较谱系分析和蛋白质预测揭示了食源性破伤风杆菌菌株的分类及毒力因子的多样性分布
Ming Zhang,Zhenzhen Yin
Ming Zhang
Background: Clostridium botulinum and Clostridium perfringens, 2 major foodborne pathogenic fusobacteria, have a variety of virulent protein types with nervous and enterotoxic pathogenic potential, respectively. ...
Comprehensive Profiling of Transcriptome and m6A Epitranscriptome Uncovers the Neurotoxic Effects of Yunaconitine on HT22 Cells [0.03%]
全转录组和m6A表观转录组分析揭示了玉蟾毒碱对HT22细胞的神经毒性作用
Beian Lin,Jian Zhang,Mengting Chen et al.
Beian Lin et al.
Objective: To explore different mRNA transcriptome patterns and RNA N6-methyladenosine (m6A) alteration in yunaconitine (YA)-treated HT22 mouse hippocampal neuron, and uncover the role of abnormal mRNA expression and RNA ...
An Effective Computational Method for Predicting Self-Interacting Proteins Based on VGGNet Convolutional Neural Network and Gray-Level Co-occurrence Matrix [0.03%]
基于VGGNet卷积神经网络和灰度共生矩阵的自相互作用蛋白质预测计算方法
Dan-Hua Chu,Ji-Yong An,Xiao-Mei Nie
Dan-Hua Chu
Introduction: Predicting Self-interacting proteins (SIPs) is a crucial area of research in predicting protein functions, as well as in understanding gene-disease and disease-drug associations. These interactions are integ...
Nam Anh Dao,Manh Hung Le,Xuan Tho Dang
Nam Anh Dao
The identification of potential interactions and relationships between diseases and drugs is significant in public health care and drug discovery. As we all know, experimenting to determine the drug-disease interactions is very expensive in...
Single-cell RNA Sequencing Identifies Natural Kill Cell-Related Transcription Factors Associated With Age-Related Macular Degeneration [0.03%]
单细胞RNA测序识别与年龄相关性黄斑变性相关的自然杀伤细胞转录因子
Yili Luo,Jianpeng Liu,Wangqiang Feng et al.
Yili Luo et al.
Background: Age-related Macular Degeneration (AMD) poses a growing global health concern as the leading cause of central vision loss in elderly people. Ob...
Recombination Events Among SARS-CoV-2 Omicron Subvariants: Impact on Spike Interaction With ACE2 Receptor and Neutralizing Antibodies [0.03%]
SARS-CoV-2奥密克戎亚变体的重组事件及其对刺突与ACE2受体和中和抗体相互作用的影响
Marwa Arbi,Marwa Khedhiri,Kaouther Ayouni et al.
Marwa Arbi et al.
The recombination plays a key role in promoting evolution of RNA viruses and emergence of potentially epidemic variants. Some studies investigated the recombination occurrence among SARS-CoV-2, without exploring its impact on virus-host int...