Yen-Chang Chang,Chun-Liang Lin,Tanagorn Jennawasin
Yen-Chang Chang
Efforts have been made to establish computer models of genetic oscillation. We have developed a real structured genetic algorithm (RSGA) which combines advantages of the traditional real genetic algorithm (RGA) with those of the structured ...
EDGE-pro: Estimated Degree of Gene Expression in Prokaryotic Genomes [0.03%]
EDGE-pro：估计基因在原核生物基因组中的表达量
Tanja Magoc,Derrick Wood,Steven L Salzberg
Tanja Magoc
Background: The expression levels of bacterial genes can be measured directly using next-generation sequencing (NGS) methods, offering much greater sensitivity and accuracy than earlier, microarray-based methods. Most bio...
A Unifying Mathematical Framework for Genetic Robustness, Environmental Robustness, Network Robustness and their Trade-off on Phenotype Robustness in Biological Networks Part I: Gene Regulatory Networks in Systems and Evolutionary Biology [0.03%]
生物网络中基因调控网络的遗传鲁棒性、环境鲁棒性、网络鲁棒性及其对表型鲁棒性的权衡研究（第一部分）数学统一框架构建系统与进化生物学中的遗传鲁棒性、环境鲁棒性、网络鲁棒性及它们之间的trade-off在生物网络中的遗传鲁棒性、环境鲁棒性、网络鲁棒性及其对表型鲁棒性的权衡研究（第I部分）：基因调控网络
Bor-Sen Chen,Ying-Po Lin
Bor-Sen Chen
Robust stabilization and environmental disturbance attenuation are ubiquitous systematic properties observed in biological systems at different levels. The underlying principles for robust stabilization and environmental disturbance attenua...
A Unifying Mathematical Framework for Genetic Robustness, Environmental Robustness, Network Robustness and their Trade-offs on Phenotype Robustness in Biological Networks. Part III: Synthetic Gene Networks in Synthetic Biology [0.03%]
基因遗传鲁棒性、环境鲁棒性、网络鲁棒性及其以生物网络为平台的表型鲁棒性的权衡问题的统一数学框架 III：合成生物学中的合成基因网络
Bor-Sen Chen,Ying-Po Lin
Bor-Sen Chen
Robust stabilization and environmental disturbance attenuation are ubiquitous systematic properties that are observed in biological systems at many different levels. The underlying principles for robust stabilization and environmental distu...
A Unifying Mathematical Framework for Genetic Robustness, Environmental Robustness, Network Robustness and their Tradeoff on Phenotype Robustness in Biological Networks Part II: Ecological Networks [0.03%]
生物网络中遗传鲁棒性、环境鲁棒性、网络鲁棒性和其表型鲁棒性权衡的统一数学框架（第二部分：生态网络）
Bor-Sen Chen,Ying-Po Lin
Bor-Sen Chen
In ecological networks, network robustness should be large enough to confer intrinsic robustness for tolerating intrinsic parameter fluctuations, as well as environmental robustness for resisting environmental disturbances, so that the phen...
A proximity-based method to identify genomic regions correlated with a continuously varying environmental variable [0.03%]
一种基于临近性的方法，识别与连续变化的环境变量相关的基因组区域
Cornelia Di Gaetano,Giuseppe Matullo,Alberto Piazza et al.
Cornelia Di Gaetano et al.
Knowledge of markers in the human genome which show spatial patterns and display extreme correlation with different environmental determinants play an important role in understanding the factors which affect the biological evolution of our ...
The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling Pathway [0.03%]
胰岛素/FOXO信号通路的分子进化模式
Minghui Wang,Qishan Wang,Zhen Wang et al.
Minghui Wang et al.
The insulin/insulin growth factor-1(IGF1)/FOXO (IIF) signal transduction pathway plays a core role in the endocrine system. Although the components of this pathway have been well characterized, the evolutionary pattern remains poorly unders...
Evolutionary Analysis of Sequence Divergence and Diversity of Duplicate Genes in Aspergillus fumigatus [0.03%]
烟曲霉基因组中重复基因的序列分化和多样化的进化分析
Ence Yang,Amanda M Hulse,James J Cai
Ence Yang
Gene duplication as a major source of novel genetic material plays an important role in evolution. In this study, we focus on duplicate genes in Aspergillus fumigatus, a ubiquitous filamentous fungus causing life-threatening human infection...
A novel multi-scale modeling approach to infer whole genome divergence [0.03%]
一种用于推断全基因组差异的新型多尺度建模方法
Eli Reuveni,Alessandro Giuliani
Eli Reuveni
We propose a novel and simple approach to elucidate genomic patterns of divergence using principal component analysis (PCA). We applied this methodology to the metric space generated by M. musculus genome-wide SNPs. Distance profiles were c...
Phylogenetic analysis and comparative genomics of purine riboswitch distribution in prokaryotes [0.03%]
嘌呤核糖开关在原核生物中的谱系分析及比较基因组学研究
Payal Singh,Supratim Sengupta
Payal Singh
Riboswitches are regulatory RNA that control gene expression by undergoing conformational changes on ligand binding. Using phylogenetic analysis and comparative genomics we have been able to identify the class of genes/operons regulated by ...