Weighted gene co-expression network analysis of hub genes in lung adenocarcinoma [0.03%]
加权基因共表达网络分析肺癌腺癌核心基因
Xuan Luo,Lei Feng,WenBo Xu et al.
Xuan Luo et al.
Lung adenocarcinoma (LUAD) is a tumor with high incidence. This study aimed to identify the central genes of LUAD. LUAD were analyzed by weighted gene co-expression network (WGCNA), and differentially expressed genes (DEGs) were identified....
Grafting Methionine on 1F1 Ab Increases the Broad-Activity on HA Structural-Conserved Residues of H1, H2, and H3 Influenza a Viruses [0.03%]
在1F1抗体上嫁接甲硫氨酸可增强其对H1、H2和H3亚型流感病毒HA结构保守位点的广谱活性
Hoa Thanh Le,Phuc-Chau Do,Ly Le
Hoa Thanh Le
A high level of mutation enables the influenza A virus to resist antibiotics previously effective against the influenza A virus. A portion of the structure of hemagglutinin HA is assumed to be well-conserved to maintain its role in cellular...
The Functional Classification of ORF8 in SARS-CoV-2 Replication, Immune Evasion, and Viral Pathogenesis Inferred through Phylogenetic Profiling [0.03%]
通过系统发育分析推断SARS-CoV-2复制、免疫逃逸和致病过程中的ORF8功能分类
Muhamad Fahmi,Hiromu Kitagawa,Gen Yasui et al.
Muhamad Fahmi et al.
ORF8 is a highly variable genomic region of SARS-CoV-2. Although non-essential and the precise functions are unknown, it has been suggested that this protein assists in SARS-CoV-2 replication in the early secretory pathway and in immune eva...
Plasmodium falciparum Malaria Parasites in Ghana Show Signatures of Balancing Selection at Artemisinin Resistance Predisposing Background Genes [0.03%]
加纳的恶性疟原虫在蒿甲醚耐药易感背景基因上显示出平衡选择的迹象
Kwesi Z Tandoh,Lucas Amenga-Etego,Neils B Quashie et al.
Kwesi Z Tandoh et al.
Sub-Saharan Africa is courting the risk of artemisinin resistance (ARTr) emerging in Plasmodium falciparum malaria parasites. Current molecular surveillance efforts for ARTr have been built on the utility of P. falciparum kelch13 (pfk13) va...
Exploration of Prognostic Biomarkers among Replication Factor C Family in the Hepatocellular Carcinoma [0.03%]
肝癌中复制蛋白C家族的预后生物标志物探索研究
Jianxiong Deng,Fangyan Zhong,Weiguo Gu et al.
Jianxiong Deng et al.
Hepatocellular carcinoma (HCC) is one of the common cancers with a high incidence and mortality. The human replication factor C (RFC) family contains 5 subunits that play an important role in DNA replication and DNA damage repair. RFCs are ...
Full-Length 16S rRNA and ITS Gene Sequencing Revealed Rich Microbial Flora in Roots of Cycas spp. in China [0.03%]
全长16S rRNA和ITS基因测序揭示了中国苏铁根部丰富的微生物群落
Melissa H Pecundo,Aimee Caye G Chang,Tao Chen et al.
Melissa H Pecundo et al.
Cycads have developed a complex root system categorized either as normal or coralloid roots. Past literatures revealed that a great diversity of key microbes is associated with these roots. This recent study aims to comprehensively determin...
Temperature and Latitude Correlate with SARS-CoV-2 Epidemiological Variables but not with Genomic Change Worldwide [0.03%]
温度和纬度与SARS-CoV-2的流行病学变量相关但与全球基因组变化无关
Prakruthi Burra,Katiria Soto-Díaz,Izan Chalen et al.
Prakruthi Burra et al.
The SARS-CoV-2 virus that causes the COVID-19 disease has spread quickly and massively around the entire globe, causing millions of confirmed cases and deaths worldwide. The disease poses a serious ongoing threat to public health. This stud...
An Intron of Invertebrate Microphthalmia Transcription Factor Gene Is Evolved from a Longer Ancestral Sequence [0.03%]
无脊椎动物microphthalmia转录因子基因的一个内含子由一个更长的祖先序列进化而来
Jun-Ming Mao,Yong Wang,Liu Yang et al.
Jun-Ming Mao et al.
Introns are highly variable in number and size. Sequence simulation is an effective method to elucidate intron evolution patterns. Previously, we have reported that introns are more likely to evolve through mutation-and-deletion (MD) rather...
NLPEI: A Novel Self-Interacting Protein Prediction Model Based on Natural Language Processing and Evolutionary Information [0.03%]
基于自然语言处理和进化信息的新型自相互作用蛋白质预测模型NLPEI
Li-Na Jia,Xin Yan,Zhu-Hong You et al.
Li-Na Jia et al.
The study of protein self-interactions (SIPs) can not only reveal the function of proteins at the molecular level, but is also crucial to understand activities such as growth, development, differentiation, and apoptosis, providing an import...
Analysis of Adaptive Evolution and Coevolution of rbc L Gene in the Genus Hildenbrandia (Rhodophyta) [0.03%]
霍氏鱼腥藻rbcL基因适应进化和协同进化的分析研究
Nan Fangru,Han Yuxin,Liu Xudong et al.
Nan Fangru et al.
The adaptive evolution and coevolution of the ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit (rbcL) gene in the genus Hildenbrandia were studied based on phylogenetic tree construction and the physicochemical properties and t...