Inhibitory Effort of MLN2238 on Basal-Like Breast Cancer: An Investigation Based on the Gene Set Enrichment Analysis [0.03%]
MLN2238抑制基底样乳腺癌的效应及基因集合富集分析研究
Dapeng Wang,Yunyan Li,Fushen Luo et al.
Dapeng Wang et al.
Basal cell-like breast cancer (BLBC), one subtype of breast cancer, has the characteristics of a high recurrence rate and strong invasiveness. Therefore, it is necessary to exploit new drugs for the therapy of BLBC. The data on small molecu...
Identification of Key Biomarkers in Hepatocellular Carcinoma Induced by Non-alcoholic steatohepatitis or Metabolic Syndrome via Integrated Bioinformatics Analysis [0.03%]
通过整合生物信息学分析识别由非酒精性肝炎或代谢综合征诱导的肝细胞癌的关键生物标志物
Bing Wang,Yiqing Zhang,Lin Gai et al.
Bing Wang et al.
The burden of hepatocellular carcinoma (HCC) is steadily growing because obesity, type 2 diabetes, and nonalcoholic fatty liver disease (NAFLD) are replacing viral- and alcohol-related liver disease as major pathogenic promoters. The curren...
Expression and clinical significance of Capase3 and C-IAP1/2 in ectopic endometrium of patients with endometriosis [0.03%]
子宫内膜异位症病灶中半胱氨酸天冬氨酸蛋白酶3和凋亡抑制蛋白1/2的表达及临床意义
Xiaoyun Zhang,Weiying Zhao
Xiaoyun Zhang
To analyze the expression of capase3 and C-IAP1/2 in endometriosis and their relationship with clinical practice. Ectopic and eutopic endometrial tissues were collected from women with endometriosis, and the control tissues were obtained fr...
miR-15a-5p up-regulates TLR4 and induces the formation of hypertrophic scars and keloids [0.03%]
miR-15a-5p上调TLR4诱导异常瘢痕形成
Junyao Pang,Lijiao Zhu,Yongquan Lv et al.
Junyao Pang et al.
The formation of hypertrophic scar and keloid is considered to be a very complex pathological process. Our previous studies have shown that miR-15a-5p is an important miRNA in HTS tissues, and its expression level is significantly increased...
Correlation Analysis of Vascular Endothelial Growth Factor Level with Clinicopathological Features and Prognosis in Patients with Diabetic Nephropathy: A Biopsy-based Study [0.03%]
糖尿病肾病患者血管内皮生长因子与临床病理特征和预后相关性分析：一项活检研究
Junlin Zhang,Huixian Zhu,Qiong Tang et al.
Junlin Zhang et al.
Globally, Type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic diseases, which poses a great potential threat to the human body. Diabetic nephropathy (DN), a very common complication in T2DM, is also the main trigger for end...
LncRNA-CBR3-AS1 promotes and enhances the malignancy of ulcerative colitis via targeting miRNA-145-5p/FN1 [0.03%]
长链非编码RNA-CBR3-AS1通过靶向miRNA-145-5p/FN1促进并增强溃疡性结肠炎的恶性表型
Jingmei Cao,Qing Zhao,Qing Jia et al.
Jingmei Cao et al.
Growing evidence suggested that long non-coding RNA (lncRNA) played a crucial role in the progression of ulcerative colitis (UC). Therefore, the purpose of this study is to understand how the lncRNA CBR3-AS1, which has been found to be up-r...
Denosumab Improves Glycaemic Parameters in Postmenopausal Osteoporosis Patients with Combined Type 2 Diabetes Mellitus [0.03%]
地舒单抗可改善绝经后骨质疏松症合并2型糖尿病患者的血糖指标
Ke Wang,Liu Gao,Chang Liu et al.
Ke Wang et al.
This study aimed to determine whether RANKL inhibitors in postmenopausal osteoporosis patients with combined type 2 diabetes mellitus (T2DM) could improve their glucose metabolism index. First of all, 84 patients affected with postmenopausa...
Regulatory effect and mechanism of LncRNA SOX2OT in idiopathic pulmonary fibrosis [0.03%]
SOX2OT环状RNA在特发性肺纤维化中的功能及机制研究
Man Qiao,Dongsheng Li,Yuan He et al.
Man Qiao et al.
This study discusses the role played by long noncoding RNA (lncRNA) SOX2OT (SOX2OT) in idiopathic pulmonary fibrosis (IPF). By inducing human embryonic lung fibroblasts (MRC5) through hypoxia, the researchers observed changes in SOX2OT expr...
Icariin prevents depression-like behaviors in chronic unpredictable mild stress-induced rats through Bax/cytoplasm C/caspase-3 axis to alleviate neuronal apoptosis [0.03%]
淫羊藿次黄酮通过Bax/细胞质C/Caspase-3轴预防慢性轻度不可预测压力诱导的大鼠抑郁行为以缓解神经元凋亡
Xiao Wu,Xiaona Zhang,Lulu Sun et al.
Xiao Wu et al.
Major depressive disorder (MDD) affects approximately 16% of the global population. Our previous study has demonstrated that icariin (ICA) exhibits anti-depressant activity by increasing the expression of Brain-Derived Neurotrophic Factor (...
Nuclear factor-kappa B p50-induced microRNA-20a-3p plays a detrimental role in sepsis-induced acute kidney injury [0.03%]
NF-κB p50诱导的miR-20a-3p在脓毒症急性肾损伤中发挥有害作用
Weihong Mao,Xiaoming Wang,Yongchen Zhang et al.
Weihong Mao et al.
Sepsis is the most common cause of acute kidney injury (AKI). Based on microarray-based clustering analysis of miRNAs altered in the kidneys of LPS-AKI mice, miR-20a-3p was upregulated in the kidney tissues of lipopolysaccharide (LPS)-treat...