NOTCH1 gene signaling pathway in the development and progression of carcinomas: an integrative review in cellular and molecular contexts [0.03%]
notch1基因信号通路在癌变发生和发展中的作用：细胞和分子角度下的整合分析
Leticia Milene Silva da Silva,Ana Gabrielly de Melo Matos,Kwang Ii Marciaga Teófilo et al.
Leticia Milene Silva da Silva et al.
The NOTCH1 gene and its signaling pathway play a critical role in the oncogenesis and progression of various carcinomas through complex cellular and molecular mechanisms. This integrative literature review examines 21 selected studies acros...
Pomegranate seed oil combined with low-frequency electromagnetic field enhances apoptosis in HT29 colon cancer cells via modulating caspase-3, caspase-9, Bax, and Bcl-2 expression [0.03%]
石榴籽油联合低频电磁场通过调节半胱天冬酶-3、半胱天冬酶-9、Bax 和 Bcl-2 表达增强 HT29 结肠癌细胞凋亡
Neda Ghorbani,Javad Baharara,Maryam Lotfi
Neda Ghorbani
Colon cancer is one of the most prevalent cancers globally, characterized by the abnormal growth of cells in the intestines. Numerous studies have explored the effects of pomegranate-derived products, such as pomegranate seed oil (PSO), as ...
Molecular mechanisms of allergic type 2 immunity in the pathogenesis of Crohn's disease: From epithelial alarmins to IgE signaling [0.03%]
过敏型2免疫的分子机制在克罗恩病发病机制中的作用：从上皮警报素到IgE信号转导
Alexander V Blagov,Marina D Sazonova,Anastasia I Ryzhkova et al.
Alexander V Blagov et al.
Crohn's disease (CD) is a chronic inflammatory bowel disorder driven by complex interactions between genetic susceptibility, gut microbiota, and immune dysregulation, typically associated with Th1 and Th17 responses. However, emerging evide...
Antiviral ribavirin binding to human serum albumin in diabetes and uraemia: A molecular docking study [0.03%]
分子对接研究中针对糖尿病和尿毒症患者的利巴韦林与人血清白蛋白结合能力的差异分析
Fahad M Almutairi,Mohammad Rehan Ajmal
Fahad M Almutairi
Human Serum Albumin (HSA) is abundant plasma protein in human blood. It plays a critical role in the transport and distribution of endogenous and exogenous compounds. Protein binding affects free fraction of a drug thus affecting pharmacoki...
Molecular insights into the interaction of Coptis teeta protoberberine alkaloids with human topoisomerase 1B-DNA complex: an integrated computational study [0.03%]
毛果芸香素小檗碱类生物碱与人拓扑异构酶1- DNA复合物相互作用的分子机制：一种集成计算研究
Jagadish Babu Dasari,Mahesh Babu Dasari,Aparna Chimalamari et al.
Jagadish Babu Dasari et al.
Human topoisomerase 1B (hTopo1B) is a validated anticancer target due to its key role in relieving torsional stress during DNA replication and transcription, as well as its overexpression in rapidly proliferating tumor cells. Camptothecin (...
The pivotal role of mitochondrial disorders in cancer development with a special focus on mitochondria-mediated apoptosis [0.03%]
线粒体疾病在癌症发展中的关键作用——特别关注线粒体介导的细胞凋亡
Alexander V Blagov,Nikolay A Orekhov,Ulyana Rozhkova et al.
Alexander V Blagov et al.
Emerging evidence indicates that mitochondrial dysfunction is not merely a consequence but a driving force in cancer progression. Unlike normal cells, cancer cells rewire their mitochondrial metabolism to support uncontrolled proliferation,...
Mengjie Xiong,Wenxian Zheng,Tongxin Jia et al.
Mengjie Xiong et al.
Telomeres are protected by the shelterin complex and consist of TTAGGG repeats. Their gradual erosion triggers replicative senescence unless counteracted by telomerase or the telomerase-independent Alternative Lengthening of Telomeres (ALT)...
Lithium carbonate attenuates behavioral alterations and partially reverses reduced prefrontal BDNF mRNA expression induced by post-weaning social isolation in male rats [0.03%]
碳酸锂改善仔鼠断奶后社会孤立诱发的雄性大鼠行为异常及降低前额叶BDNF mRNA表达
Hanieh Mansouri Dobarji,Batool Ghorbani Yekta,Mahsa Ale-Ebrahim et al.
Hanieh Mansouri Dobarji et al.
Social isolation is an environmental stressor that can adversely affect behavioral function and neuroplasticity-related pathways. Brain-derived neurotrophic factor (BDNF) is one of the key molecules implicated in these changes. Lithium has ...
Differential effects of high-sucrose and high-fat diets on metabolic syndrome, BBB integrity, and hippocampal Aβ accumulation [0.03%]
高蔗糖和高脂肪饮食对代谢综合征、血脑屏障完整性及海马区Aβ沉积影响的差异性研究
Carlos Francisco Aguilar-Gamas,Eduardo Martínez-Abundis,Erick De la Cruz-Hernández et al.
Carlos Francisco Aguilar-Gamas et al.
Metabolic syndrome (MS) is a global health problem and a recognized risk factor for cognitive impairment and Alzheimer's disease (AD), but the different effects of specific dietary components on MS-related neurological damage remain unclear...
Mohsen Almakrami,Zubair Ahmed,Ghadah M Alali et al.
Mohsen Almakrami et al.
Cancer is the leading cause of morbidity and mortality globally, underscoring the need for precise diagnostic approaches and effective therapeutic strategies. The invention of the CRISPR (Clustered Regularly Interspaced Short Palindromic Re...