Circ_0006251 mediates the proliferation and apoptosis of vascular smooth muscle cells in CAD via enhancing TET3 and PPM1B expression [0.03%]
circ_0006251通过增强TET3和PPM1B的表达介导冠状动脉疾病血管平滑肌细胞增殖及凋亡
Weibing Zhong,Lin Wang,Lingbing Xiong
Weibing Zhong
Coronary artery disease (CAD) is a serious global problem that has been considered to be a major cause of death. Circular RNAs (circRNAs) as a key player in the regulation of cardiac progression and disease. Nevertheless, most circRNAs are ...
LOXL1-AS1 promotes cell proliferation in hepatocellular carcinomathrough miR-1224-5p/ITPRIPL2/AKT axis [0.03%]
LOXL1-AS1通过miR-1224-5p/ITPRIPL2/AKT轴促进肝细胞癌细胞增殖
Tangen Chen,Shuyun Zeng,Quanyuan Liu et al.
Tangen Chen et al.
LncRNA has been validated to be related to different cancers, whereas its regulation mechanism in hepatocellular carcinoma (HCC) is poorly known. In this study, LOXL1-AS1 was overexpressed in HCC cell lines, and LOXL1-AS1 knockdown represse...
Application Value of Next-Generation Sequencing of Bronchial Alveolar Lavage Fluid in Emergency Patients with Infection [0.03%]
急诊感染患者的支气管肺泡灌洗液下一代测序应用价值评估研究
Weiqin Wu,Xiang Han,Hongmei Zhao et al.
Weiqin Wu et al.
This study was performed to explore the application value of next-generation sequencing (NGS) of bronchial alveolar lavage fluid (BALF) in emergency patients with infection. In this regard, a total of 52 patients with infection who were dia...
DUSP1 regulates the JAK2/STAT3 signaling pathway through targeting miR-21 in cervical cancer cells [0.03%]
DUSP1通过靶向miR-21调节Janus激酶2/信号转导和转录激活因子3信号通路在宫颈癌细胞中的作用
Hailin Chen,Songsen Ren,Hui Wan et al.
Hailin Chen et al.
This study was to investigate the effect of DUSP1 on cervical cancer (CC) cells by targeting the miR-21 regulatory JAK2/STAT3 signaling pathway. For this purpose, fifteen CC patients treated at our hospital from January 2021 to February 202...
Expression and Function of VEGFRs in Normal Epidermis and Psoriatic Lesional Keratinocytes [0.03%]
正常表皮和银屑病皮损角质形成细胞VEGFR表达及功能差异的研究
Yong Wang,Yong Yan,Huiwen Yu et al.
Yong Wang et al.
The study aimed to explore the expression and function of VEGFRs in normal epidermis and keratinocytes of psoriatic lesions. In this study, the expression and role of VEGFRs in keratinocytes were examined using examples from psoriatic and h...
Bioinformatics-based analysis of core genes and pathway enrichment in early diabetic nephropathy [0.03%]
基于生物信息学的早期糖尿病肾病核心基因及通路富集分析
Yangwenxuan Han,Xiaoyan Liu,Jing Shang et al.
Yangwenxuan Han et al.
Diabetic nephropathy (DN) is the main cause of end-stage renal disease (ESRD). Bioinformatics technology was adopted to screen and analyze the core genes of early DN to explore its pathogenesis. GSE30528, GSE96804, and GSE30122 chip data we...
The discovery of the natural compound Boeravinone-C as a potential antiobesity drug candidate targeting pancreatic lipase using chemo-informatics-based approaches [0.03%]
基于化学信息学方法发现天然产物博尔纳vinone C作为靶向胰脂肪酶的潜在减肥药物候选物
Aziz Unnisa,Sirajuddin Anwar,Chettupalli Ananda K et al.
Aziz Unnisa et al.
Obesity is a metabolic disorder distinguished by excess fat deposition in fatty tissues. Pancreatic lipase is one of the promising drug targets for treating obesity due to its critical role in the hydrolysis of triglycerides into mono-glyce...
Effects of celecoxib on AQP-1, NF-κB and apoptosis in lung tissue of neonatal rats with hyperoxia-induced lung injury [0.03%]
塞来昔布对氧损伤新生儿大鼠肺组织AQP-1、NF-κB及凋亡的影响
Zhengfei Fan,Yuan Shen
Zhengfei Fan
To analyze the effects of AQP-1, NF-κB and apoptosis in lung tissue of neonatal rats with hyperoxia-induced lung injury (HILI).162 neonatal SD rats were divided into control group (COG), model group (MOG) and celecoxib group (CEG), 54 rats...
Secretion of related factors and AMPK/PGC-1 α signal pathway by alveolar macrophages in viral acute lung injury [0.03%]
病毒感染所致急性肺损伤中肺泡巨噬细胞相关因子的释放及AMPK/PGC-1α信号途径的影响
Zhengfei Fan,Jiawei Zhu
Zhengfei Fan
This study was to investigate the secretion of related factors by alveolar macrophages and AMPK/PGC-1 α signal pathway in viral acute lung injury (VALI) patients. 30 SD rats were randomly divided into blank control group (BCG) and VALI gro...
Effect of 4-AP on MPP+/ MPTP-induced Parkinson's disease model [0.03%]
4-AP对1-甲基-4-苯基吡啶离子/1-甲基-4-苯基四氢吡啶诱导的帕金森病模型的影响
Qiongwen Rong,Chang Zhou,Yuanyuan Ma
Qiongwen Rong
To study the effect of 4-AP on Parkinson's disease (PD) cells and animal model. PD cells were pretreated with different concentrations of 4-AP for 24 hours, then PD cells were prepared by MPP+, and the cell activity was detected by CCK8 kit...