Endogenous ligand of the APJ receptor Apelin-13 inhibits cell apoptosis and oxidative stress of cardiomyocytes [0.03%]
内源性APJ受体配体阿普利林-13抑制心肌细胞凋亡及氧化应激作用研究
Hu Jin,Longmeng Cao,Dachao Tang et al.
Hu Jin et al.
The present study aimed to investigate the effect of Apelin-13 on nicotine-induced injuries of cardiomyocytes. To establish an H9c2 cell model of nicotine-induced apoptosis, H9c2 cells were divided into the control group, nicotine group, an...
Detection of TP53 gene mutation in blood of breast cancer patients based on circulating tumor DNA and its application in prognosis [0.03%]
基于循环肿瘤DNA的乳腺癌患者TP53基因突变的血液检测及其预后价值研究
Qiran Lu,Luxin Wei,Shenbin Cai et al.
Qiran Lu et al.
This experiment was carried out to explore the application value of high throughput gene sequencing technology in detecting TP53 gene mutations in the blood of patients with breast cancer by detecting ctDNA gene mutations, and exploring the...
Actin cytoskeleton aggregation involves the water channel protein aquaporin 1-mediated human chondrocyte degeneration [0.03%]
肌动蛋白细胞骨架聚集涉及水通道蛋门蛋白1介导的人类软骨细胞退变
Xiaoliang Chen,Xiucai Ma,Peng Liu et al.
Xiaoliang Chen et al.
Water metabolism and actin cytoskeleton remoulding act as essential characters in the process of osteoarthritis (OA). However, the relation between water channel protein aquaporin 1 (AQP1) and actin filament during chondrocytes (CHs) degene...
A novel necroptosis-related model predicts the prognosis and immunocompetence of head and neck squamous cell carcinoma [0.03%]
一种新的坏死性凋亡相关模型可预测头颈鳞状细胞癌的预后和免疫学特征
Jixia Zhang,Anli Wang,Lin Qiu
Jixia Zhang
Head and neck squamous cell carcinoma (HNSCC) is a disease characterized by profound immunosuppression and the prognosis of HNSCC patients remains poor. Necroptosis is a programmed lytic cell-death mechanism that can promote tumor growth, a...
Inhibition of Galectin-1 attenuates lung fibroblast activation and proliferation in lung fibrosis [0.03%]
抑糖蛋白-1可减轻肺纤维化中肺成纤维细胞活化和增殖
Jing Xue,Shaojun Li
Jing Xue
The purpose of this study was to investigate the parenchymal changes in idiopathic pulmonary fibrosis (IPF) caused by massive fibroblastic infiltration and proliferation in lung tissue. Galectin-1 (Gal-1) has been reported to be involved in...
Ghrelin alleviates hypoxia/reoxygenation-induced H9C2 injury by activating autophagy and AMPK/ULK1 pathway [0.03%]
ghrelina通过激活自噬和AMPK / ULK1通路缓解H9C2细胞的缺氧/复氧损伤
Hui Liu,Wei Lv,Li Ouyang et al.
Hui Liu et al.
The research aims to explore the protective effects of ghrelin and its underlying molecular mechanisms in an H9C2 hypoxia/reoxygenation model. H9C2 cells were transfected with ghrelin overexpression lentiviral vector. The hypoxia/reoxygenat...
Effect of IP-10/CXCR3 signaling pathway on rats with diabetic retinopathy [0.03%]
IP-10/CXCR3信号通路对糖尿病视网膜病变大鼠的影响
Fei Ji,Hongjie Zhang,Qian Ge
Fei Ji
This study aimed to investigate the effect of the interferon-inducible protein-10 (IP-10)/C-X-C motif chemokine receptor 3 (CXCR3) signaling pathway on rats with diabetic retinopathy. A total of 21 Sprague-Dawley rats were selected as the o...
Modulation of muscarinic receptors by anisodine hydrobromide in cerebral ischemia [0.03%]
氢溴酸阿尼丁对脑缺血的毒扁豆碱受体调节作用
Feng Wan,Linlu Jin,Yixue Qin et al.
Feng Wan et al.
Ischemic cerebrovascular diseases pose significant challenges due to their high mortality, disability rates, and recurrence risk, imposing substantial societal and healthcare burdens. Current treatment modalities, including medication and s...
The effect of Cornus mas extract on nıcotıne-ınduced oxıdatıve stress and ıntratestıcular damage ın male rats [0.03%]
Cornus mas提取物对雄性大鼠尼古丁诱导的氧化应激和曲细精管损伤的影响
Ünal Öztekin,Mehmet Caniklioğlu,Şükrü Ateş et al.
Ünal Öztekin et al.
The role of oxidative stress in disease pathogenesis has been extensively investigated. Researchers have gathered sufficient evidence related to oxidative stress-mediated intratesticular damage. The aim of this was study to evaluate the eff...
Study on the reversal of epileptic drug resistance by tetramethylpyrazine in combination with carbamazepine through modulation of P-Glycoprotein expression in rat brain microvessel endothelial cell [0.03%]
四甲吡嗪联合卡马西平逆转难治性癫痫的研究及其对脑血管内皮细胞P-糖蛋白表达的调节作用研究
Xia Qian,Yuqing Deng,Na Zhong et al.
Xia Qian et al.
The purpose of this study was to detect the changes of P-Glycoprotein (P-GP) expression in rat brain microvessel endothelial cell line RBE4 after the action of Tetramethylpyrazine (TMP) on Carbamazepine (CBZ), so as to clarify the potential...