Down-regulation of abaI, abaR, Bap and OmpA genes in Acinetobacter baumannii by ethanol extract of Glycyrrhiza glabra after toxicity assessment [0.03%]
毒力评估后甘草醇提取物下调阿伯菌abaI，abaR，Bap和OmpA基因
Trefa Salih Mohamad,Jwan Khidhr Rahman,Akhter Ahmed Ahmed et al.
Trefa Salih Mohamad et al.
Acinetobacter baumannii is a pathogen that has caused rising concerns within healthcare facilities in recent years. As antibiotic overuse and resistance rise, natural remedies with the potential have received attention as antibiotics that m...
Saxagliptin reduces the injury of Alzheimer's disease cell model by down-regulating the expression of miR-483-5p [0.03%]
saxagliptin通过下调miR-483-5p的表达降低阿尔茨海默病细胞模型的损伤
Yiting Hou,Lihua Dong,Lihua Cao
Yiting Hou
This study aimed to investigate the effect of saxagliptin on the injury of Alzheimer's disease (AD) cell model and its possible mechanism. SK-N-SH cells were cultured in vitro and divided into CON group, AD group, AD+L-SAX group, AD+M-SAX g...
CircBCAR3 sponges miR-27a-3p and mediates ferroptosis in human B-prolymphocytic leukaemia cells via SLC7A11 [0.03%]
Circular RNA CircBCAR3通过SLC7A11介导铁死亡调控人类B细胞性淋巴瘤细胞系中miR-27a-3p的功能研究
Guangwei Zhao,Huan Chen,Jianmin Luo
Guangwei Zhao
B-lymphocytic leukaemia is one of the most commonly diagnosed blood malignancies, and our knowledge of B-prolymphocytic leukaemia remained barely comprehensive. CircRNAs and miRNAs were identified of important regulatory roles in tumours. T...
MicroRNA-126-3P targets PIK3R2 to ameliorate autophagy and apoptosis of cortex in hypoxia-reoxygenation treated neonatal rats [0.03%]
microRNA-126-3P靶向PIK3R2缓解缺氧复氧大鼠皮层的自噬及凋亡
Jingjing Ge,Xiaoling Jiao,Hui Li
Jingjing Ge
Here, we explored a possible mechanism of microRNA-126-3p (miR-126-3p) on neonatal rats with hypoxia-reoxygenation injury (HI). After administering HI to newborn Sprague-Dawley rats, the expression of miR-126-3p in the brain injury was asse...
Identification of novel immune infiltration-related biomarkers of sepsis based on bioinformatics analysis [0.03%]
基于生物信息学分析的脓毒症相关新型免疫浸润标志物识别
Hua Li,Le Yang
Hua Li
This study aimed to analyze the gene expression characteristics of sepsis and search for potential biomarkers involved in the pathogenesis. The data on sepsis were obtained from the GEO database according to the keyword "sepsis". The CIBERS...
Resveratrol protects against high glucose-induced steroidogenesis and apoptosis in murine granulosa cells [0.03%]
白藜芦醇通过调节小鼠颗粒细胞中AMPK信号通路抑制高糖诱导的类固醇生成和凋亡
Ning Zhang,Yinghua Shan,Huayu Lian et al.
Ning Zhang et al.
Resveratrol (Res) is a polyphenolic compound that exhibits a diverse array of biological effects. Herein, we detected the ability of Res on murine granulosa cells (GCs) against impaired steroidogenesis and apoptotic death in response to hig...
LncRNA DCST1-AS1 drives the malignant progression of pediatric acute myeloid leukemia via regulating p53 methylation [0.03%]
长链非编码RNA DCST1-AS1通过调节p53甲基化驱动儿童急性髓系白血病恶性进展
Jian Wang,Yan Li,Zhe Xu et al.
Jian Wang et al.
To uncover the biological role of lncRNA DCST1-AS1 in the process of pediatric AML and its regulatory effect on p53 methylation. Serum level of DCST1-AS1 in AML children and healthy participants was detected by qRT-PCR. The role of DCST1-AS...
Ferroptosis-associated lncRNA prognostic signature predicts prognosis and immune response in laryngeal squamous carcinoma [0.03%]
与铁死亡相关长链非编码RNA预后标志物可预测喉部鳞癌的预后和免疫应答
Yuan Dong,Kai Zhao,Qibing Qiu et al.
Yuan Dong et al.
In order to construct a prognostic model of ferroptosis-related lncRNA associated with laryngeal carcinoma and to investigate its prognostic value, RNA sequencing, genomic mutation, and clinical data of laryngeal squamous carcinoma patients...
MiR-26a-5p exerts its influence by targeting EP300, a molecule known for its role in activating the PI3K/AKT/mTOR signaling pathway in CD8+tumor-infiltrating lymphocytes of colorectal cancer [0.03%]
MicroRNA-26a-5p通过靶向EP300在结直肠癌CD8+肿瘤浸润淋巴细胞PI3K/AKT/mTOR信号通路中发挥作用
Chao Wang,Haonan Lin,Wangqiang Zhao et al.
Chao Wang et al.
Surgical resection remains the primary approach for treating colorectal cancer, which is among the prevalent types of cancers affecting the digestive system. Tumor-infiltrating lymphocyte (TIL) therapy has emerged as a prominent area of stu...
The expression of p53, ki67 and COX-2 in erosive-type oral lichen planus [0.03%]
萎缩型扁平苔藓口腔黏膜癌变相关标志物的研究
Sayf Aziz,Shehab Hamad,Yosra Qasim
Sayf Aziz
Oral lichen planus is a chronic inflammatory disease that affects the oral mucosa and may undergo malignant changes, which can be reflected in the expression of specific proteins that are responsible for maintaining cellular mitosis and apo...