Molecular docking study and ADMET prediction of the effects of some food alkaloids on thyroxine homeostasis through their interactions with human thyroxine-binding globulin [0.03%]
几种食物生物碱与人四碘甲状腺原氨酸结合球蛋白相互作用影响四碘甲状腺原氨酸稳态的分子对接研究及药物代谢预测
Naima Maouche,Nesrine Lenchi
Naima Maouche
Thyroid hormones (THs) play a vital role in several physiological functions of the body. At the circulatory level, thyroxine (T4) has been found to be the predominant form of THs. The distribution of T4 in the blood is mainly carried out by...
Bitter frankincense water modulates hepatic enzyme activity in female patients with irritable bowel syndrome [0.03%]
乳香调节女性肠易激综合征患者的肝酶活性
Khamaal Hussein Abod Al-Khafaji,Zahraa Mohammed Fakheir,Shaimaa Mohammed Ali Jasim
Khamaal Hussein Abod Al-Khafaji
This study aimed to determine and know the effect of bitter frankincense water on the levels of the functional liver enzymes in female patients with irritable bowel syndrome. This study was conducted in the consulting laboratories for patho...
Identification of novel variants with predicted pathogenicity as key targets in esophageal cancer [0.03%]
识别出具有致病性预测的新变异作为食管癌的关键靶点
Waqas Ahmad Abbasi,Sajida Qureshi,Muhammad Asif Qureshi et al.
Waqas Ahmad Abbasi et al.
Esophageal cancer (EC) remains a major global health challenge due to its aggressive nature and poor prognosis. Genetic alterations play a crucial role in tumor progression; however, a deeper understanding of the genetic landscape of EC is ...
Epigenetic and genetic events of oral squamous cell carcinoma: perspective on DNA methylation, silencing of tumor suppressor gene, and activating oncogenes [0.03%]
口腔鳞状细胞癌的表观遗传和基因事件：DNA甲基化、抑癌基因沉默及原癌基因激活的观点
Zainab Nizar Jawad
Zainab Nizar Jawad
Oral squamous cell carcinoma (OSCC) is a major health burden in most parts of the world, and pathogenesis of the disease is strongly associated with a complex combination between genetic mutations and epigenetic alterations. The current stu...
Molecular detection of Epstein-Barr virus in invasive ductal carcinoma of the breast: a case-control study [0.03%]
乳腺浸润性导管癌中EB病毒分子检测的病例对照研究
Mahmoud Mohammed Mahmoud,Abdulla Kamil Abdulla,Dler Omar Mohammed
Mahmoud Mohammed Mahmoud
The uncertain contribution of Epstein-Barr virus (EBV) to the etiological processes underlying invasive ductal carcinoma (IDC) of the mammary gland, especially in relation to its molecular interactions within inflamed histological contexts,...
Expression patterns and clinical significance of MMP-8, MMP-9 and MMP-13 in colorectal cancer [0.03%]
基质金属蛋白酶MMP-8、MMP-9和MMP-13在结直肠癌中的表达及临床意义
Rezvaneh Ghadyani,Zahra Mozooni,Zihab Sohbatzadeh et al.
Rezvaneh Ghadyani et al.
Colorectal cancer (CRC) is the most common malignancy of the gastrointestinal system in the world. By identifying specific gene expression patterns that indicate CRC in the early stages, it is possible to potentially diagnose the disease in...
Investigation of ovarian aging markers and hormonal regulation in menopausal transition [0.03%]
绝经过渡期卵巢衰老标记物及激素调节机制的研究
Samah Amer Hammood,Noor Alamer,Mohammed Kareem S ALquraish et al.
Samah Amer Hammood et al.
Menopause and ovarian dysfunction are consequences of ovarian aging, a continuous and natural process in women. Early symptoms of ovarian aging include inadequate response to ovarian stimulation, irregular menstruation, and loss of follicul...
Reciprocal regulation of mir-10b, aurora-a, p53, and e-cadherin in cisplatin resistance and cell invasion of lung cancer [0.03%]
肺癌顺铂耐药及细胞侵袭中mir-10b、aurora-a、p53和e-cadherin的相互调节作用研究
Chen-Chu Lin,Chun-Chi Wu
Chen-Chu Lin
Lung cancer remains a leading cause of cancer-related deaths in developed nations, including Taiwan, mainly due to drug resistance or malignant conditions such as metastasis. Abnormal expression levels of oncogenes or tumor suppressors are ...
Combinatorial targeting of PI3K/AKT pathway with BKM120 increases cisplatin sensitivity and apoptotic response in A549 lung cancer cells [0.03%]
PI3K途径的组合靶向制剂BKM120能够增加顺铂对A549肺癌细胞的敏感性并增强其促凋亡反应
Sara Razi,Fattah Sotoodehnejadnematalahi,Sepideh Chodary Khameneh et al.
Sara Razi et al.
Despite significant advancements in the treatment of non-small cell lung cancer (NSCLC) using conventional therapeutic methods, drug resistance remains a major factor contributing to disease recurrence. In this study, we aimed to explore th...
Multi drug resistant Pseudomonas aeruginosa in burn infection among Iraq patients [0.03%]
伊拉克烧伤患者的多重耐药铜绿假单胞菌感染
Wasnaa Jomaa Mohammed,Hala Mohammed
Wasnaa Jomaa Mohammed
Pseudomonas aeruginosa is a prominent opportunistic pathogen, especially in burn wound infections, and is often associated with high morbidity and mortality due to its multidrug resistance (MDR) characteristics.This study aimed to evaluate ...