Oxidized low-density lipoprotein induces M2-type differentiation of macrophages to promote the protracted progression of atherosclerotic inflammation in high-fat diet-fed ApoE -/- mice [0.03%]
氧化的低密度脂蛋白诱导巨噬细胞产生M2型分化，促进高脂饮食喂养的ApoE基因敲除小鼠动脉粥样硬化炎症的持续进展
Bo Zhang,Weichang Xia,Jingqun Zhou et al.
Bo Zhang et al.
In this study, the significance of oxidized low-density lipoprotein (ox-LDL) in promoting the progression of atherosclerosis was investigated by inducing the differentiation of macrophages into the M2 subtype within a high-fat diet-induced ...
Ulinastatin protects against myocardial ischemia/reperfusion injury in rats via Rho/ROCK signaling pathway [0.03%]
乌拉斯坦通过Rho/ROCK信号通路保护大鼠心肌缺血再灌注损伤
Ling Liu,Jun Liu,Junshuai Wang et al.
Ling Liu et al.
We aimed to study the influences of ulinastatin on diseased myocardial tissues, cardiomyocyte apoptosis and inflammatory reaction in rats with myocardial ischemia/reperfusion injury (IRI) via the Ras homolog (Rho)/Rho-associated kinase (ROC...
Melatonin reduces myocardial cell damage in myocardial ischemia/reperfusion rats by inhibiting NLRP3 activation [0.03%]
褪黑素通过抑制NLRP3活化减少心肌缺血/再灌注大鼠的心肌细胞损伤
Shurong Li,Xiang Li,Fang Xie et al.
Shurong Li et al.
Melatonin (Mel) is an endogenous hormone with many pharmacological effects, such as sedation, hypnosis, antidepressant, blood pressure regulation, anti-inflammatory and anti-tumor. It is mainly synthesized by pineal gland in vivo. Mel can r...
LINC00339 accelerates invasion and migration of colorectal cancer via mediating miRNA-30a-5p [0.03%]
LINC00339通过介导miRNA-30a-5p促进结直肠癌的侵袭和迁移
Peng Zhou,Jie Wu,Zihan Zheng et al.
Peng Zhou et al.
To analyze the biological function of LINC00339 in the progression of colorectal cancer (CRC). We aim to provide directions in the early-stage treatment of CRC. LINC00339 level in 60 paired CRC tissues and paracancerous tissues was examined...
Anti- IL-22 neutralizing antibodies decrease inflammation lesions and reduce mortality in enterovirus 71-infected mice [0.03%]
抗IL-22中和抗体降低肠道病毒71感染小鼠的炎症病变并降低死亡率
Chang Zhang,Sa Tang,Xue Zong et al.
Chang Zhang et al.
Hand, foot, and mouth disease (HFMD) can cause fatal encephalitis in 0-5-year-old infants and children. There is no effective antiviral drug available to treat HFMD caused by enterovirus 71 (EV71). Our study investigates the relationship be...
Association of Orai1 and Peizo1 genes expression with cellular proliferation, metastasis and angiogenesis biomarkers in colon tumor biopsies of CRC patients [0.03%]
CRC患者结肠肿瘤活检标本中Orai1和Peizo1基因表达与细胞增殖、转移及血管生成生物标志物的关联性研究
Farhang Awla,Goran Othman
Farhang Awla
Colon cancer is a complex malignancy characterized by intricate molecular interactions that influence its progression. This study investigates the role of calcium channel gene expression (ORAI1 and Piezo1) and their interplay with angiogene...
Next-generation sequencing and immunohistochemistry approaches for microsatellite instability detection in endometrial cancer [0.03%]
下一代测序和免疫组化在子宫内膜癌微卫星不稳定性检测中的应用方法
Azhin Saber Ali,Lana Sardar Alalem
Azhin Saber Ali
The purpose was to determine the effectiveness of immunohistochemical observation, a quick and easy method for determining Microsatellite instability MSI and/or other types of endometrial cancer (EC) based on modern classification. As molec...
LncRNA TEX41 promotes the proliferation and migration of squamous cell carcinoma cells by upregulating Atg5 via sponging miR-153-3p [0.03%]
长链非编码RNA TEX41通过海绵吸附miR-153-3p上调Atg5促进鳞状细胞癌细胞增殖和迁移
Wenbo Yang,Yuyou Chen
Wenbo Yang
This study was conducted to investigate if lncRNA TEX41 could have effects on SCC. The aim was to confirm that TEX41 could promote SCC progression by up-regulating Atg5 via miR-153-3p. TEX41, miR-153-3p, and Atg5 mRNA expression were examin...
Prognostic potential of MNX1-AS1 in chemotherapy of colorectal carcinoma [0.03%]
MNX1-AS1在结直肠癌化疗中的预后潜力
Guangjun Zhong,Ming Zhou,Zhaojun Wang et al.
Guangjun Zhong et al.
To clarify the role of MNX1-AS1 in 5-FU resistance of Colorectal carcinoma (CRC). Relative levels of MNX1-AS1 in CRC and paracancerous tissues were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Recruited CRC patien...
Xue Li,Dan Li
Xue Li
Malignant tumors are one of the diseases that are most threatening to the health of people and their life. Moreover, it has already had a great impact on social and financial problems. With the further development of science and technology,...