TMAO converts cytochrome c into a pro-apoptotic peroxidase by destabilizing the heme-Met80 ligation [0.03%]
胆碱代谢物TMAO通过破坏血红素-Met80配位将细胞色素c转化为促凋亡过氧化物酶
Kuldeep Singh,Anju Kumari,Seemasundari Yumlembam et al.
Kuldeep Singh et al.
Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, has been linked to cardiovascular, renal, and hepatic disorders, but its direct impact on mitochondrial apoptotic machinery remains unclear. Here, we show that TMAO binds c...
Activation of the Na/K-ATPase oxidant amplification loop by uremic toxins drives adipocyte dysfunction in vitro [0.03%]
尿毒症毒素激活Na/K-ATP酶氧化应激放大环驱动体外脂肪细胞功能障碍
Hari Vishal Lakhani,Muhammad A Chaudhry,Tilak Khanal et al.
Hari Vishal Lakhani et al.
Oxidative stress is a major contributor to chronic kidney disease (CKD) progression. In experimental CKD, circulating uremic toxins (UTs) increase reactive oxygen species (ROS) production, triggering the Na/K-ATPase-ROS amplification loop (...
Structural dynamics of PCSK9 loss-of-function variants: implications for LDL cholesterol regulation and cardiovascular risk [0.03%]
PCSK9功能丧失型变异体的结构动力学：对LDL胆固醇调节和心血管风险的影响
Mohammed Tarique,Ayyub Ali Patel,Ayaz Khurram Mallick et al.
Mohammed Tarique et al.
Cardiovascular disease (CVD) is a leading global cause of mortality, and understanding its underlying mechanisms is crucial for developing effective interventions. The liver-derived protein PCSK9 (proprotein convertase subtilisin/kexin-type...
MiR-200b-3p is involved in colorectal cancer progression by targeting DDIT4 [0.03%]
微RNA-200b-3p通过靶向DDIT4参与结直肠癌进展
Zhimin Liu,Yiping Li,Shangkui Xie et al.
Zhimin Liu et al.
This study aimed to explore the functional dynamics between microRNA-200b-3p (miR-200b-3p) and DNA damage-induced transcript 4 (DDIT4) in colorectal cancer (CRC) and their potential as therapeutic targets. Pan-cancer analysis was conducted ...
Ayed A Dera,Mesfer Al Shahrani,Gaffar Sarwar Zaman et al.
Ayed A Dera et al.
A glycogen storage disease (GSD) is a metabolic disorder caused by a deficiency of an enzyme or transport protein affecting glycogen synthesis, glycogen breakdown, or glucose breakdown, typically in muscles and/or liver cells. Several enzym...
Xanthohumol suppresses ECM degradation in osteoarthritis through the Nrf2/ PERK/ATF4/C/EBPβ signaling pathway [0.03%]
姜黄素通过Nrf2/PERK/ATF4/C/EBPβ信号通路抑制骨关节炎的ECM降解作用
Tiansheng Zheng,Shuo Niu,Qingluo Zhou et al.
Tiansheng Zheng et al.
In this study, the therapeutic efficacy of Xanthohumol (XH) was evaluated as a preventive agent for extracellular matrix (ECM) degradation in osteoarthritis, using the in vivo monosodium iodoacetate-induced arthritis model in rats, along wi...
Allele frequency of CTLA-4 rs231775 (+49 A>G) gene polymorphism and its association with cancer susceptibility in the Saudi Arabian population and other ethnic groups [0.03%]
CTLA-4 rs231775(+49 A>G)基因多态性的allele频率及其与沙特阿拉伯人群和其它人种癌症易感性的关联分析
Mohammad Salman Akhtar,Raed A Alharbi,Arshi Talat et al.
Mohammad Salman Akhtar et al.
Single-nucleotide polymorphisms (SNPs) of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene found in exon 1 are directly associated with the progression and onset of autoimmune disease and various human cancers. These SNPs are commonly kno...
CircFOXK2 induces non-small cell lung cancer tumorigenesis through the miR-328-5p/PKP3 axis [0.03%]
Circular RNA CircFOXK2通过miR-328-5p/PKP3轴促进非小细胞肺癌发生发展
Tongwei Xiang,Liping Chen,Huaying Wang et al.
Tongwei Xiang et al.
Circular RNAs (circRNAs) are non-coding RNAs (ncRNAs) implicated in the onset and advancement of various human cancers. Among these, circFOXK2 has been linked to non-small cell lung cancer (NSCLC); however, its precise functions and underly...
Glycation-mediated binding defect in human serum albumin transport of erdosteine: implications in diabetes [0.03%]
人血清白蛋白厄多司汀转运的糖基化介导结合缺陷：在糖尿病中的意义
Nada Mahmoud Dhab&#x;an Al-Atawi,Ohud Mohammed Ahmad Al-Harbi,Rasha Sulaiman Muhammad Al-Finaikh et al.
Nada Mahmoud Dhab&#x;an Al-Atawi et al.
Human serum albumin (HSA) is a protein in human blood primarily responsible for transporting ligands. Erdosteine is an important drug used in the treatment of acute and chronic respiratory diseases. This study employed molecular docking and...
Shared gene functions in autoimmune diseases identified via integrated bioinformatics analysis [0.03%]
基于整合生物信息学分析的自身免疫性疾病共有基因功能研究
Saniye Elvan Öztürk
Saniye Elvan Öztürk
Genetic transmission has minimal impact on autoimmune diseases compared to environmental factors. In conclusion, studies now focus on gene expression changes for diagnosis and treatment. This study used stringent cut-off values (p < 0.0...