A systematic review of the toxicity of salsolinol and its metabolites [0.03%]
_salsoniol及其代谢物毒性的系统评价研究论文
Jasmine Kaur Sidhu,Hong Yu Wong,Beek Yoke Chin et al.
Jasmine Kaur Sidhu et al.
Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline) is a tetrahydroisoquinoline compound formed by the condensation reaction between dopamine and acetaldehyde. While it plays a role in normal physiological functions at physio...
Whole-grain millets attenuate atherosclerosis by modulating cholesterol metabolism and the FGF-2/PI3K/Akt and Wnt-1/β-catenin pathways in high-cholesterol-fed rats [0.03%]
全谷米糠通过调节胆固醇代谢及FGF-2/PI3K/Akt和Wnt-1/β-连环蛋白信号通路抑制高胆固醇饮食大鼠动脉粥样硬化病变发展
Haritha Rajan,Abhirami Sunitha,Mani Sebastian et al.
Haritha Rajan et al.
Millets, rich in nutrients, have the potential to enhance immunity and combat diseases, including atherosclerosis. As a chronic inflammatory disease contributing to high global mortality, atherosclerosis involves key signaling pathways such...
Structure-based identification of liensinine as a natural allosteric SHP2 inhibitor with anti-proliferative activity in HepG2 cells [0.03%]
基于结构的梁辛素作为SHP2别构抑制剂的研究及其在HepG2细胞中的增殖抑制作用
Beom Su Seo,Dong Oh Moon
Beom Su Seo
SHP2, encoded by the PTPN11 gene, is a non-receptor tyrosine phosphatase that plays a key role in oncogenic Ras/MAPK signaling. Aberrant SHP2 activity contributes to the progression of various cancers, including liver cancer. In this study,...
Characterization of COVID-19 patients in clinical, epidemiological, and laboratory settings: the role of vitamin D binding protein and vitamin D level in severity [0.03%]
临床、流行病学和实验室环境中新冠肺炎患者的特征：维生素D结合蛋白及维生素D水平在疾病严重程度中的作用
Aleen Sardar Al-Noori,Ahmed Mohamed Salih,Muayad Aghali Merza
Aleen Sardar Al-Noori
There are contradictory findings on the role of vitamin D-binding protein in COVID-19 development, disease severity, and outcomes. Therefore, we aimed to explore the association between the serum vitamin D level, DBP, and the COVID-19 sever...
Curcumin-mediated synthesis of copper-doped TiO2 nanocomposite for potentially promising antioxidant, wound healing, and anti-apoptosis [0.03%]
姜黄素介导合成铜掺杂二氧化钛纳米复合材料用于抗氧化、伤口愈合和抗细胞凋亡研究
Saja Zubair Dhabian,Mustafa Taher Hatem
Saja Zubair Dhabian
The paper provides a green, eco-friendly synthesis and analysis of a novel curcumin-based, copper-doped titanium dioxide nanocomposite (CuO/TiO2 -Curcumin NC). Curcumin was also utilized as a green reducing agent and also capping agent ther...
Inhibition of the RIPK1-driven necroptotic pathway protects against hypotensive and tachycardic responses to LPS in a rat model of septic shock [0.03%]
利用RIPK1介导的坏死性凋亡通路抑制保护内毒素诱导的失血性休克早期低血压和心动过速反应
Bahar Tunctan,Sefika Pinar Senol,Dilsah Ezgi Yilmaz et al.
Bahar Tunctan et al.
Necroptosis, a lytic type of cell death that is dependent on RIPK1-activated RIPK3 and MLKL, has been implicated in the progression of septic shock-related events. However, the role of RIPK1/RIPK3/MLKL necrosome in hemodynamic alterations a...
Multidimensional assessment of natural ligands fisetin, morin and rutin against factor XIIa activity using in vitro and in silico studies [0.03%]
基于体外和分子对接研究的天然配体衍生化合物抑制FXIIa活性的构效关系研究
Hassan A Madkhali
Hassan A Madkhali
The discovery of selective inhibitors of factor XIIa (FXIIa) is an attractive approach for development of new antithrombotics that do not interfere with normal hemostasis. Here we report an in vitro chromogenic assay and in silico molecular...
Abdoul Karim Ouattara,Issoufou Tao,Julien Dembélé et al.
Abdoul Karim Ouattara et al.
Toll-like receptor 3 (TLR3) is a key component of the innate immune system that recognizes viral double-stranded RNA (dsRNA) as well as endogenous RNA released from necrotic cells. Unlike other TLRs, TLR3 signals exclusively through the TIR...
The role of an immunohistochemical panel including CD45, CK5/6, and ER in classifying challenging breast lesions in Iraqi pathology [0.03%]
包括CD45、CK5/6和ER的免疫组化谱系在伊拉克病理中的作用：用于分类具有挑战性的乳腺病变
Saman Rafeeq Abdullah
Saman Rafeeq Abdullah
Accurate diagnosis of breast lesions is often complicated by the morphological overlap between benign, pre-malignant, and malignant entities on hematoxylin and eosin (H&E) stained sections. This study evaluated the diagnostic utility of an ...
Chronic inflammation in the development of colorectal cancer: pathological model and therapeutic targets [0.03%]
慢性炎症与结直肠癌发生发展：病理模型和治疗靶点
Alexander Blagov,Nikolay Shakhpazyan,Olga Maltseva et al.
Alexander Blagov et al.
Colorectal cancer is very severe and a hard disease to treat because it is the second most deadly type of cancer in the world. The primary causes of mortality from colorectal cancer, which can be associated with a common and potentially fat...