Synthetic cation transporters incorporating crown ethers and calixarenes as headgroups and central relays: a comparison of sodium and chloride selectivity [0.03%]
以冠醚和杯芳烃为主链连接头的合成阳离子转运蛋白：钠离子与氯离子的选择性比较
José Carlos Iglesias-Sánchez,Wei Wang,Riccardo Ferdani et al.
José Carlos Iglesias-Sánchez et al.
An earlier study showed that a calix[4]arene could function as a central relay unit to form an ion conductance pathway through a phospholipid bilayer membrane. The present study expands the range of compounds from calix[4]arene to calix[6]a...
Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications [0.03%]
具备优异蛋白表达活性的mRNA研究及单个硫代磷酸修饰的ARCA四聚体合成性质研究
Malwina Strenkowska,Joanna Kowalska,Maciej Lukaszewicz et al.
Malwina Strenkowska et al.
We describe the chemical synthesis and preliminary biophysical and biochemical characterization of a series of mRNA 5' end (cap) analogs designed as reagents for obtaining mRNA molecules with augmented translation efficiency and stability i...
RNA structural motifs that entail hydrogen bonds involving sugar-phosphate backbone atoms of RNA [0.03%]
涉及RNA糖磷酸骨架原子氢键的RNA结构基元
Nikolai B Ulyanov,Thomas L James
Nikolai B Ulyanov
The growing number of high-resolution crystal structures of large RNA molecules provides much information for understanding the principles of structural organization of these complex molecules. Several in-depth analyses of nucleobase-center...
A Stereoselective Intramolecular Cyclopropanation via a De Novo Class of Push-Pull Carbenes Derived from DMDO-Epoxidations of Chiral Ynamides [0.03%]
通过手性炔胺的DMDO环氧化物衍生的新一类推拉卡宾实现立体选择性分子内环丙烷化
Hongyan Li,Jennifer E Antoline,Jin-Haek Yang et al.
Hongyan Li et al.
This work describes the first examples of diastereoselective intramolecular cyclopropanations of a de novo class of push-pull carbenes derived from DMDO-epoxidations of chiral ynamides. This reaction sequence essentially constitutes a tande...
Algorithms for the determination of binding constants and enantiomeric excess in complex host : guest equilibria using optical measurements [0.03%]
基于光学测量的复杂主客体体系中结合常数及对映过量测定的算法研究
Amanda E Hargrove,Zhenlin Zhong,Jonathan L Sessler et al.
Amanda E Hargrove et al.
The determination of binding constants is central to many areas of research, supramolecular chemistry in particular. Traditional nonlinear regression analysis, however, cannot be applied to complex systems unless certain assumptions are und...
Effect of Peptide-Chelate Architecture on Metabolic Stability of Peptide-based MRI Contrast Agents [0.03%]
肽基MRI对比剂的代谢稳定性受螯合结构的影响
Zhaoda Zhang,Andrew F Kolodziej,Jianfeng Qi et al.
Zhaoda Zhang et al.
A strategy for preparing high relaxivity, metabolically stable peptide-based MR contrast agents is described.
Singlet oxygen generation using iodinated squaraine and squaraine-rotaxane dyes [0.03%]
碘代苯并双螺烯和轮烷染料生成单线态氧
Easwaran Arunkumar,Pallikkara K Sudeep,Prashant V Kamat et al.
Easwaran Arunkumar et al.
The goal of this study was to assess the ability of squaraine-rotaxanes to generate singlet oxygen for potential application in photodynamic therapy (PDT). Specifically, we compare the aggregation and photophysical properties of an iodinate...
Partition of compounds from water and from air into amides [0.03%]
化合物从水和空气向酰胺的转移/partition of compounds from water and air into amides
Michael H Abraham,William E Acree,J Enrique Cometto-Muñiz
Michael H Abraham
Literature data on partitioning of compounds from the gas phase to a number of amides and from water to the amides has been collected and analyzed through the Abraham solvation equations. The resulting equations are statistically good enoug...
A divergent route towards single-chemical entity triazine dendrimers with opportunities for structural diversity [0.03%]
一种合成三嗪型单分子树枝状化合物的新方法及其结构多样性研究获奖科研成果名称示例奖项名称示例提名专家姓名示例科研团队负责人姓名示例科研项目名称示例科研项目来源示例科研成果所属单位示例科研成果类型名称示例科研成果名称示例
Hannah Crampton,Emily Hollink,Lisa M Perez et al.
Hannah Crampton et al.
This manuscript describes the successful synthesis and characterization of five generations of dendrimers based on melamine. Early generations of these materials appear to be single chemical entities: upon purification, no detectable impuri...
Polycationic triazine-based dendrimers: effect of peripheral groups on transfection efficiency [0.03%]
基于三嗪的多阳离子树状分子：臂端基团对转染效率的影响
Meredith A Mintzer,Olivia M Merkel,Thomas Kissel et al.
Meredith A Mintzer et al.
A panel of eight, second generation triazine dendrimers differing in the number of amines, guanidines, hydroxyls and aliphatic groups on the periphery was synthesized and assayed for gene transfer in an attempt to correlate the effects of s...