Cationic liposome-nucleic acid complexes for gene delivery and gene silencing [0.03%]
阳离子脂质体-核酸复合物的基因传递及基因沉默作用
Cyrus R Safinya,Kai K Ewert,Ramsey N Majzoub et al.
Cyrus R Safinya et al.
Cationic liposomes (CLs) are studied worldwide as carriers of DNA and short interfering RNA (siRNA) for gene delivery and gene silencing, and related clinical trials are ongoing. Optimization of transfection efficiency and silencing efficie...
Synthesis and Structural Characterization of 1-Arylimidazole-2-thiones and N, N'-Aryldiethoxyethylthioureas with Electronically Diverse Substituents: A Manifold of Hydrogen Bonding Networks [0.03%]
具有电子多样性取代基的1-芳基咪唑-2-噻酮和N，N'-芳基二乙氧基亚甲基硫脲的合成与结构表征：多样的氢键网络
Joshua H Palmer,Gerard Parkin
Joshua H Palmer
The 1-arylimidazole-2-thiones, (HmimAr) [Ar = 3,4,5-C6H2(OMe)3, 2,4-C6H3(NO2)(OMe), 2,4,6-C6H2Cl3 and 3,5-C6H3(CF3)2], which feature electronically diverse substituents, may be obtained via acid-catalyzed ring closure of the corresponding N...
Yih Horng Tan,Kohki Fujikawa,Papapida Pornsuriyasak et al.
Yih Horng Tan et al.
Monoliths of nanoporous gold (np-Au) were modified with self-assembled monolayers of octadecanethiol (C18-SH), 8-mercaptooctyl α-D-mannopyranoside (αMan-C8-SH), and 8-mercapto-3,6-dioxaoctanol (HO-PEG2-SH), and the loading was assessed us...
Highly Sensitive Simultaneous Detection of Mercury and Copper Ions by Ultrasmall Fluorescent DNA-Ag Nanoclusters [0.03%]
超小型荧光DNA-Ag纳米簇的高灵敏度同时检测汞和铜离子的方法
Shengliang Li,Weipeng Cao,Anil Kumar et al.
Shengliang Li et al.
Fluorescent metal nanoclusters (NCs) have given rise to a new class of fluorescent nanomaterials for the detection of heavy metals. Here, we design a simple, rapid and highly sensitive sensing nanosystem for the detection of Hg2+ and Cu2+ b...
A facile microwave-assisted protocol for rapid synthesis of N-acetylneuraminic acid congeners [0.03%]
一种简便的微波辅助合成N-乙酰神经氨酸类似物的方法
Jonel P Saludes,Dhananjaya Sahoo,I Abrrey Monreal
Jonel P Saludes
We developed a simple, rapid and efficient microwave irradiation-assisted protocol that is 1- to 2-orders of magnitude faster than conventional techniques, providing an expedient access to the sialic acid congeners Neu5Ac1Me (1), Neu5Acβ1,...
Endonuclease and Exonuclease Activities on Oligodeoxynucleotides Containing Spiroiminodihydantoin Depend on the Sequence Context and the Lesion Stereochemistry [0.03%]
寡脱氧核糖核酸中的内切酶和外切酶活性取决于序列环境和立体化学性质
Xin Chen,Aaron M Fleming,James G Muller et al.
Xin Chen et al.
8-Oxo-7,8-dihydro-2'-deoxyguanosine (dOG), a well-studied oxidation product of 2'-deoxyguanosine (dG), is prone to facile further oxidation forming spiroiminodihydantoin 2'-deoxyribonucleoside (dSp) in the nucleotide pool and in single-stra...
R Rajasekhar Reddy,Krishna R Raghupathi,Diego Amado Torres et al.
R Rajasekhar Reddy et al.
In the past decade, there has been an increasing interest in supramolecular systems that can undergo physical or chemical tranformations upon encountering a specific stimulus. Micelle-forming amphiphilic systems based on polymers and dendri...
Katie M Feher,Hai Hoang,Michael P Schramm
Katie M Feher
A fluorescently labeled resorcinarene cavitand has been successfully embedded in DLPC lipid vesicles and imaged using confocal microscopy. The cavitand resides exclusively in the bilayer.
Alan Dehope,Daniel Mendoza-Espinosa,Bruno Donnadieu et al.
Alan Dehope et al.
Deprotonation of N,N-diisopropyl-C-ferrocenylaldiminium triflate 2 cleanly leads to the corresponding 1,2-diamino-1,2-diferrocenylethene 3, the dimer of the desired (amino)(ferrocenyl)carbene. Fulvene 6, obtained by addition of the lithium ...
TUD-1: synthesis and application of a versatile catalyst, carrier, material… [0.03%]
TUD-1：一种多功能催化剂、载体和材料的合成及应用
Selvedin Telalović,Anand Ramanathan,Guido Mul et al.
Selvedin Telalović et al.
The three-dimensional sponge-like mesoporous material TUD-1 is straightforward to prepare. Its synthesis can readily be modified to introduce metals into the framework of TUD-1, imparting many different catalytic activities. M-TUD-1 catalys...