Three-Component [3+2] Cycloaddition for Regio- and Diastereoselective Synthesis of Spirooxindole-Pyrrolidines [0.03%]
通过三组分[3+2]环加成反应合成螺氧吲哚-吡咯烷类化合物
Xiaofeng Zhang,Miao Liu,Desheng Zhan et al.
Xiaofeng Zhang et al.
1,3-Dipolar cycloaddition of nonstabilized azomethine ylides derived from α-C-H functionalization of tetrahydroisoquinoline for regio- and diastereoselective synthesis of spirooxindole-pyrrolidines is developed. A three-component reaction ...
Anti-cancer activity of heteroaromatic acetals of andrographolide and its isomers [0.03%]
andrographolide杂芳酰胺及其异构体的抗肿瘤活性研究
Nitesh Tamang,Christopher Andrews,Sai Kiran Mavileti et al.
Nitesh Tamang et al.
Acetals (2a-d, 3a-d, and 6a-d) of andrographolide (1), 14-deoxy-12-hydroxyandrographolide (4), and isoandrographolide (5) were synthesized using benzaldehyde and heteroaromatic aldehydes. All the synthesized derivatives were characterized u...
Thermodynamics of Pillararene•Guest Complexation: Blinded Dataset for the SAMPL9 Challenge [0.03%]
pillararene•客体分子包合物的热力学数据：第十九届SAMPL系列盲预测挑战专题之三
Chun-Lin Deng,Ming Cheng,Peter Y Zavalij et al.
Chun-Lin Deng et al.
We report an investigation of the complexation between a water soluble pillararene host (WP6) and a panel of hydrophobic cationic guests (G1 - G20) by a combination of 1H NMR spectroscopy and isothermal titration calorimetry in phosphate bu...
Efficient Synthesis of 6,6´-Diamido-2,2´-dipicolylamine Ligands for Potential Phosphate Anion Sensing [0.03%]
高效合成用于潜在磷酸根离子检测的六六'二胺-2,2'-二吡啶基胺配体
Shuai Wang,Lichong Gong,Georges El Fakhri et al.
Shuai Wang et al.
We report here the efficient synthesis of 6,6´-diamido-2,2´-dipicolylamines (DA-DPAs) which could be applied to phosphate anion sensing via pre-formed metal complexes. The design was based on the retrosynthetic analysis. This strategy ena...
Application of Site-Identification by Ligand Competitive Saturation in Computer-Aided Drug Design [0.03%]
基于竞争饱和配体的药物作用位点计算识别及其在计算机辅助药物设计中的应用研究
Himanshu Goel,Anthony Hazel,Wenbo Yu et al.
Himanshu Goel et al.
Site Identification by Ligand Competitive Saturation (SILCS) is a molecular simulation approach that uses diverse small solutes in aqueous solution to obtain functional group affinity patterns of a protein or other macromolecule. This invol...
Sven Kirschner,Kang Yuan,Michael J Ingleson
Sven Kirschner
Haloboration, the addition of B-X (X = Cl, Br, I) across an unsaturated moiety e.g., C[double bond, length as m-dash]Y or C[triple bond, length as m-dash]Y (Y = C, N, etc.), is dramatically less utilised than the ubiquitous hydroboration re...
Silvia Cercatillo,Michael Friedrich,Bernd Kromer et al.
Silvia Cercatillo et al.
In this study we aim to identify the optimal cellulose extraction protocol for 14C dating of wood, with a focus on glacial trees. To achieve this, we compare three cellulose extraction methods on the basis of cellulose yield and 14C age. Th...
Triptycene Walled Glycoluril Trimer: Synthesis and Recognition Properties [0.03%]
三苯并二环戊二烯型笼状甘油尿素三聚体的合成与识别性质研究
Sandra Zebaze Ndendjio,Wenjin Liu,Nicolas Yvanez et al.
Sandra Zebaze Ndendjio et al.
We report the synthesis of a new acyclic CB[n]-type host (1) that features a central glycoluril trimer capped by triptycene sidewalls. Host 1 has good solubility in water (≈ 3 mM) and does not undergo strong self-association (Ks = 480 M-1)...
Benign Synthesis of Fused-thiazoles with Enone-based Natural Products and Drugs for Lead Discovery [0.03%]
基于内酯和烯酮类天然产物及药物的噻唑并杂环生物碱的衍生化反应研究
Rawan Alnufaie,Mohamad Akbar Ali,Ibrahim S Alkhaibari et al.
Rawan Alnufaie et al.
In an effort to synthesize a library of bioactive molecules, we present an efficient synthesis of fused-thiazole derivatives of natural products and approved drugs by using an environmentally usable solvent, acetic acid, and without any ext...
Vitaliy M Sviripa,Michael V Fiandalo,Kristin L Begley et al.
Vitaliy M Sviripa et al.
Androgen-deprivation therapy (ADT) is only a palliative measure, and prostate cancer invariably recurs in a lethal, castration-resistant form (CRPC). Prostate cancer resists ADT by metabolizing weak, adrenal androgens to growth-promoting 5...