Very late entecavir resistance after more than 10 years of therapy in a treatment-naïve patient with chronic hepatitis B genotype D3 [0.03%]
初始感染乙型肝炎病毒D3型的患者经恩替卡韦治疗超过十年后仍产生非常晚发的耐药变异
David Pereira Santiago,María Elisabeth Prieto Rodríguez,Elena Fernández Ruiz
David Pereira Santiago
Entecavir resistance in nucleos(t)ide-naïve patients with chronic hepatitis B is exceptional because of its high genetic barrier. We report a case of progressive virological breakthrough after more than 10 years of effective entecavir ther...
Beyond the scalpel ‒ The critical impact of lifestyle and tumor biology in non-cirrhotic hepatocellular carcinoma [0.03%]
超越手术刀——非肝硬化性肝细胞癌的生活方式和肿瘤生物学的critical影响
Paula Fernández-Álvarez,Andrés Castaño-García,María Varela Calvo
Paula Fernández-Álvarez
The epidemiological landscape of hepatocellular carcinoma (HCC) is shifting from viral-dominated etiologies toward metabolic dysfunction-associated steatotic liver disease (MASLD). While the majority of cases still occur within the context ...
Automated extraction of colonoscopy quality indicators from free-text reports using a prompt-based large language model pipeline [0.03%]
基于提示的大语言模型管道自动生成结肠镜检查质量指标报告摘要
Alda Andrade,Diogo Rodrigues,Helena Ribeiro et al.
Alda Andrade et al.
Background and aims: Artificial intelligence has increasingly enabled large-scale analysis of clinical documentation, offering new opportunities to improve quality monitoring in endoscopy. In colonoscopy, key quality indi...
Ultra-processed food intake and risk of inflammatory bowel disease in the adult population ‒ A systematic review and meta-analysis [0.03%]
超加工食品摄入与成人炎症性肠病风险的系统评价和meta分析
Raúl Mendoza-Rodríguez,Álvaro Gutiérrez-Garrido,Rita Jiménez-Rosales et al.
Raúl Mendoza-Rodríguez et al.
Purpose: The incidence of inflammatory bowel disease has risen in recent years. Although its pathophysiology remains unclear, evidence suggests that dietary factors, especially ultra-processed foods, may play a role. ...
Persistent geographic inequalities in oesophageal cancer mortality in Spain despite overall declines [0.03%]
尽管总体下降西班牙食管癌死亡率的地理差异仍然持久
Lucía Cayuela,Sara Cabrera Fernández,Gema Flox-Benítez et al.
Lucía Cayuela et al.
Background: Oesophageal cancer remains a leading cause of cancer mortality worldwide, with marked geographical variation. This study examined sex-specific temporal trends and subnational spatial patterns in oesophageal ca...
Diagnostic and therapeutic considerations in m.3243A>G-associated chronic intestinal pseudo-obstruction [0.03%]
线粒体DNA m.3243A>G突变相关慢性肠梗阻的诊疗考虑
Josef Finsterer
Josef Finsterer
We read with interest the article by Zhang et al. about an 18-year-old female carrier of the m.3243A>G variant in the MT-TL1 gene. Clinically, the mutation manifested as MELAS syndrome (mitochondrial encephalopathy, lactic acidosis, and str...
EUS-guided diagnosis of gastric adenocarcinoma with sarcomatoid differentiation: when mucosal biopsy is not the whole story [0.03%]
内镜超声引导下的胃腺癌伴梭形细胞分化病变的诊断：当黏膜活检不能说明全部问题时
Fengmei Ma,Lirong Liu
Fengmei Ma
A 65-year-old man presented with gastric outlet obstruction and marked neutrophil-predominant leukocytosis. Gastroscopy showed an infiltrative antral lesion, and superficial biopsy revealed moderately differentiated adenocarcinoma. However,...
Outcomes of laser hemorrhoidoplasty in grade II-IV hemorrhoidal disease: a four-year, single center experience [0.03%]
激光治疗II-IV度痔病的疗效：一项为期四年的单中心经验分析
Lotte Heynderickx,Bart Van Geluwe,Celine De Meyere et al.
Lotte Heynderickx et al.
Background: Open hemorrhoidectomy remains the gold standard for the surgical treatment of hemorrhoidal disease but is associated with substantial postoperative pain and complications. In contrast, Laser Hemorrhoidoplasty ...
Diffuse micronodular gastric metastases from invasive lobular breast carcinoma ‒ Characterization of an unusual endoscopic pattern [0.03%]
弥漫性微小结节型胃转移癌在侵袭性乳头状乳腺导管癌中的内镜表现及特征描述
Miguel Casado Portolés,Cristina Olmedo Moreno,Ana González Blanco et al.
Miguel Casado Portolés et al.
Gastric metastases from breast cancer are uncommon and may mimic primary gastric neoplasia, particularly in invasive lobular carcinoma. We report a 72-year-old woman with previous luminal B/HER2-negative invasive lobular breast carcinoma an...
Juan Berenguer,José Antonio Pérez-Molina
Juan Berenguer
Anal cancer has traditionally received limited attention, partly because of its low incidence compared with other gastrointestinal malignancies. However, this situation may be changing. Although uncommon, anal cancer is increasingly recogni...