Neuropeptide FF receptor 2 inhibits capsaicin-induced CGRP Upregulation in mouse trigeminal ganglion [0.03%]
神经活性肽FF受体2通过抑制鼠三叉神经节中辣椒素诱导的CGRP上调发挥镇痛作用
Ya-Tin Lin,Zachary Yu,Sze-Chi Tsai et al.
Ya-Tin Lin et al.
Background: Stimulation of trigeminovascular pathway is widely used to establish the headache animal model. Headache is a common neurological disorder, in which symptomatic attacks are mediated by calcitonin-gene-related ...
Administrative prevalence and incidence, characteristics and prescription patterns of patients with migraine in Germany: a retrospective claims data analysis [0.03%]
德国偏头痛患者的患病率和发病率、患者特征及处方模式：回顾性保险数据研究
Tatjana Roessler,Juergen Zschocke,Anne Roehrig et al.
Tatjana Roessler et al.
Background: Migraine is a frequent headache disorder with high disease burden. The aims of this study were to determine the administrative prevalence and incidence of migraine in Germany; and to elucidate disease characte...
Acute sleep deprivation enhances susceptibility to the migraine substrate cortical spreading depolarization [0.03%]
急性睡眠剥夺增强了对 migraine substrate cortical spreading depolarization 的易感性
Andrea Negro,Jessica L Seidel,Thijs Houben et al.
Andrea Negro et al.
Background: Migraine is a common headache disorder, with cortical spreading depolarization (CSD) considered as the underlying electrophysiological event. CSD is a slowly propagating wave of neuronal and glial depolarizati...
Erenumab in highly therapy-refractory migraine patients: First German real-world evidence [0.03%]
依瑞歐馬單抗治療三叉神經阻斷失敗的偏頭痛患者：德國真實世界證據之首個案例
Armin Scheffler,Olga Messel,Sebastian Wurthmann et al.
Armin Scheffler et al.
Background: Calcitonin gene related peptide (CGRP) monoclonal antibodies (mAB) are the first specific migraine prophylactic medication. Erenumab is the only CGRP mAB targeting the CGRP receptor. Clinical data regarding ef...
P2X7 receptors exert a permissive effect on the activation of presynaptic AMPA receptors in rat trigeminal caudal nucleus glutamatergic nerve terminals [0.03%]
P2X7受体在大鼠三叉神经延髓核谷氨酸能神经末端发挥对前突触AMPA受体激活的允许作用
Diego Currò,Pierluigi Navarra,Irene Samengo et al.
Diego Currò et al.
Background: Purine receptors play roles in peripheral and central sensitization and are associated with migraine headache. We investigated the possibility that ATP plays a permissive role in the activation of AMPA recepto...
F Antonaci,S Arceri,M Rakusa et al.
F Antonaci et al.
Background: Trigeminal neuralgia (TN) is a severe, disabling form of painful cranial neuropathy. Even though TN has a typical clinical picture, diagnosis it is often missed or delayed in clinical practice. In order to inv...
Impact of primary headache disorder on quality of life among school students in Kuwait [0.03%]
科威特学生原发性头痛对生活质量的影响
Jasem Y Al-Hashel,R Alroughani,S Shuaibi et al.
Jasem Y Al-Hashel et al.
Background: Primary headache disorders have being increasingly reported in younger populations. They can have significant effects on their quality of life and academic achievement and may cause significant distress to the...
Migraine start, course and features over the cycle of combined hormonal contraceptive users with menstrual migraine - temporal relation to bleeding and hormone withdrawal: a prospective diary-based study [0.03%]
复方口服避孕药使用者的偏头痛发作、病程和特征与月经周期的关系——与出血及激素撤退的时间关系：一项基于日记的研究
Gabriele S Merki-Feld,Nina Caveng,Gina Speiermann et al.
Gabriele S Merki-Feld et al.
Background: Many studies have described the features of menstrually-related migraines (MRM) in the natural cycle and the efficacy of prevention. MRM in combined hormonal contraceptive (CHC) users has scarcely been researc...
Effect of age on pharmacokinetics, efficacy, and safety of galcanezumab treatment in adult patients with migraine: results from six phase 2 and phase 3 randomized clinical trials [0.03%]
年龄对成人偏头痛患者galcanezumab治疗的药代动力学、疗效和安全性的影响：六项II期和III期随机临床试验结果
Virginia L Stauffer,Ira Turner,Phebe Kemmer et al.
Virginia L Stauffer et al.
Background: Migraine clinical profile may change with age, making it necessary to verify that migraine treatments are equally safe and effective in older patients. These analyses evaluated the effects of patient age on th...
Addressing chronic persistent headaches after MTBI as a neuropathic pain state [0.03%]
脑部轻度创伤后慢性持续性头痛作为神经病理性疼痛状态的治疗
Albert Leung
Albert Leung
An increasing number of patients with chronic persistent post-traumatic headache (PPTH) after mild traumatic brain injury (MTBI) are being referred to headache or pain specialists as conventional treatment options for primary headache disor...