Intravascular Endothelin-1 does not trigger or increase susceptibility to Spreading Depolarizations [0.03%]
血管内皮素-1不能触发或增加扩散去极化发生的倾向性
Kazutaka Sugimoto,Andreia Morais,Homa Sadeghian et al.
Kazutaka Sugimoto et al.
Objectives: Spreading depolarizations (SD) likely manifest as aura in migraineurs. Triggers are unknown although vascular events have been implicated. Direct carotid puncture has been reported to trigger migraine with aur...
Cindy Tiseo,Alessandro Vacca,Anton Felbush et al.
Cindy Tiseo et al.
Migraine and sleep disorders are common and often burdensome chronic conditions with a high prevalence in the general population, and with considerable socio-economic impact and costs.The existence of a relationship between migraine and sle...
A cross-sectional study on the burden and impact of migraine on work productivity and quality of life in selected workplaces in the Philippines [0.03%]
菲律宾选定工作场所 migraine 对劳动生产率和生活质量影响的负担的横断面研究
Nel Jason Haw,Ian Theodore Cabaluna,Germaine Erika Kaw et al.
Nel Jason Haw et al.
Background: Migraine imposes a substantial personal and economic burden to many working age individuals. This study aimed to evaluate the burden and impact of migraine on work productivity in selected workplaces in the Ph...
A proof-of-concept study on CGRP plasma levels of migraineurs during a 6-month treatment with ERENUMAB [0.03%]
使用ERENUMAB治疗6个月期间偏头痛患者CGRP血浆水平的概念验证研究
Giuseppe Tringali,Catello Vollono,Paolo Calabresi et al.
Giuseppe Tringali et al.
The introduction of monoclonal antibodies (mAbs) against calcitonin-gene related peptide (CGRP) or CGRP receptors in the treatment of migraine raised concerns on the possible risks associated to the long-term inhibition of CGRP physiologica...
Impact of galcanezumab on total pain burden: findings from phase 3 randomized, double-blind, placebo-controlled studies in patients with episodic or chronic migraine (EVOLVE-1, EVOLVE-2, and REGAIN trials) [0.03%]
Galcanezumab对总体疼痛负担的影响：在阵发性或慢性偏头痛患者中进行的III期随机双盲安慰剂对照研究的结果(EVOLVE-1，EVOLVE-2和REGAIN试验)
Jessica Ailani,J Scott Andrews,Mallikarjuna Rettiganti et al.
Jessica Ailani et al.
Background: Focus on the frequency of migraine pain may undervalue the total burden of migraine as pain duration and severity may present unique, additive burden. A composite measure of total pain burden (TPB; frequency, ...
Plasma levels of CGRP and expression of specific microRNAs in blood cells of episodic and chronic migraine subjects: towards the identification of a panel of peripheral biomarkers of migraine? [0.03%]
阵发性与慢性偏头痛病人血浆CGRP水平和血液细胞中特异的microRNA表达：寻找外周血液偏头痛标志物？
Rosaria Greco,Roberto De Icco,Chiara Demartini et al.
Rosaria Greco et al.
Background: Migraine can manifest with an episodic or a chronic pattern in a continuum of disease severity. Multiple factors are associated with the progression of the pattern from episodic to chronic. One of the most con...
Özge Uygun,Mustafa Ertaş,Esme Ekizoğlu et al.
Özge Uygun et al.
Background: Headache is the most common COVID-19-related neurological symptom. We aimed to reveal diagnostic clues of headache for COVID-19 infection and to investigate the course of primary headaches during the pandemic....
Eptinezumab for the prevention of chronic migraine: efficacy and safety through 24 weeks of treatment in the phase 3 PROMISE-2 (Prevention of migraine via intravenous ALD403 safety and efficacy-2) study [0.03%]
Eptinezumab用于预防慢性偏头痛：在三期临床试验PROMISE-2（通过静脉注射ALD403预防偏头痛的安全性和有效性研究-2）中，观察24周的疗效和安全性
Stephen Silberstein,Merle Diamond,Nada A Hindiyeh et al.
Stephen Silberstein et al.
Background: PROMISE-2 was a phase 3, randomized, double-blind, placebo-controlled study that evaluated the efficacy and safety of repeat intravenous (IV) doses of the calcitonin gene-related peptide-targeted monoclonal an...
Response inhibition alterations in migraine: evidence from event-related potentials and evoked oscillations [0.03%]
偏头痛中的反应抑制改变：来自事件相关电位和诱发振荡的证据
Guoliang Chen,Yansong Li,Zhao Dong et al.
Guoliang Chen et al.
Background: Migraine is characterized by a hypersensitivity to environmental stimulation which climaxes during headache attacks but persists during attack-free period. Despite ongoing debates about the nature of the mecha...
My Migraine Voice survey: disease impact on healthcare resource utilization, personal and working life in Finland [0.03%]
我的 migraine voice 研究调查：疾病对医疗资源利用，和个人及工作生活的影响在芬兰
Marja-Liisa Sumelahti,Markku Sumanen,Merika S Sumanen et al.
Marja-Liisa Sumelahti et al.
Background: A global My Migraine Voice survey was conducted in 31 countries among 11,266 adults who suffered from ≥4 monthly migraine days (MMD). The aim of this retrospective observational survey-based study was to anal...