Medial prefrontal cortex-targeted low-intensity focused ultrasound alleviates migraine-related allodynia and affective symptoms via modulating glutamate/GABA balance in mice [0.03%]
靶向中前额叶皮层的低强度聚焦超声通过调节谷氨酸/γ-氨基丁酸平衡来缓解小鼠偏头痛相关性痛觉过敏和情感症状
Jiayi Liu,Mingjie Zhang,Qiuquan Cai et al.
Jiayi Liu et al.
Background: Migraine affects nearly one billion people worldwide and remains a major global health burden with inadequate treatment options. In this study, transcranial low-intensity focused ultrasound (LIFU) targeting th...
Rimegepant for the acute treatment of migraine: a systematic review and meta-analysis [0.03%]
瑞美吉泮治疗偏头痛的急性发作：系统性回顾和荟萃分析
Melissa Istoc,Basit A Chaudhry,Rune H Christensen et al.
Melissa Istoc et al.
Objective: To determine the efficacy and tolerability of a single 75 mg oral dose of rimegepant compared with placebo for the acute treatment of migraine attacks in adults. ...
Brain structural MRI changes before and after 6 months of preventive treatment with erenumab and onabotulinumtoxinA in migraine [0.03%]
偏头痛患者在预防性使用依瑞欧马托和肉毒杆菌毒素A治疗前后大脑结构MRI的变化
Joana Rosell-Mirmi,Edoardo Caronna,Víctor J Gallardo et al.
Joana Rosell-Mirmi et al.
Background: Structural neuroimaging findings in migraine remain heterogeneous, and the impact of preventive treatments such as erenumab and onabotulinumtoxinA (OnabotA) on brain plasticity is poorly understood. We aimed t...
Multimodal serum and MRI signatures of neuroaxonal injury in high-frequency migraine [0.03%]
高频偏头痛的神经轴突损伤的多模态血清和MRI特征
Víctor J Gallardo,Edoardo Caronna,Joana Rosell-Mirmi et al.
Víctor J Gallardo et al.
Background: It remains unclear whether high-frequency migraine is associated with objective markers of possible neuroaxonal injury and potential expression of neurodegenerative hallmarks. We compared serum and MRI biomark...
A neural substrate for targeted analgesia associated with attenuated serotonergic transmission in a mouse model of medication overuse headache [0.03%]
与药物过度使用性头痛小鼠模型中血清素能传递减弱相关的靶向镇痛的神经介质
Deqi Zhai,Chunxiao Yang,Zihua Gong et al.
Deqi Zhai et al.
Background: Medication overuse headache (MOH) is a chronic disorder due to excessive acute headache treatment use. Neuroimaging studies suggest the involvement of the orbitofrontal cortex (OFC) in the pathophysiology of M...
Impaired glymphatic function and advanced brain age gap in chronic migraine: a multimodal MRI study [0.03%]
慢性偏头痛患者的糖淋巴功能障碍及脑衰老差距：多模态磁共振成像研究
Chenyu Dai,Fangwang Fu,Yu Guo et al.
Chenyu Dai et al.
Objectives: This study investigated whether the coupling between cortical blood-oxygen-level-dependent (BOLD) signals and cerebrospinal fluid (CSF) flow, a physiologically motivated but indirect proxy related to glymphati...
Connar Stanley James Westgate,Tanja Lylloff,David Møbjerg Kristensen et al.
Connar Stanley James Westgate et al.
Background: Cluster headache is associated with compensated hypogonadism in males, suggesting impaired testicular steroidogenesis. It is unknown if adrenal steroidogenesis is dysregulated and how this is linked to cluster...
Patterns of headache in patients with antiphospholipid syndrome in relation to autoantibodies [0.03%]
抗磷脂综合征患者头痛的模式与自身抗体的关系
Radwa Soliman,Youssra Gadallah Mahfouz,Rania Gamal Anwar El-Skaan et al.
Radwa Soliman et al.
Background: The interplay between Antiphospholipid syndrome (APS) and migraine is very controversial; migraine is believed to be the most common neurologic symptom in APS, and there are claims that migraineurs have abnorm...
What's a migraine day? Towards a consensus definition for clinical care and research - a Delphi panel-based study [0.03%]
什么是偏头痛发作日？临床护理和研究中一致定义的共识——基于德尔菲专家组的研究
Luna De Loose,Koen Paemeleire,Christina I Deligianni et al.
Luna De Loose et al.
Background: Although guidelines for controlled trials have proposed a definition for a migraine day, substantial variability remains across clinical trials, highlighting the need for a universally adopted definition. ...
Shuu-Jiun Wang,Tsubasa Takizawa,Jiying Zhou et al.
Shuu-Jiun Wang et al.
Migraine is a debilitating neurovascular disorder affecting over one billion people globally. While reported prevalence in Asia is lower than in Western countries, significant regional variations and unique clinical presentations necessitat...