Real-world impact of fremanezumab on migraine symptoms and resource utilization in the United States [0.03%]
关于福美奈珠单抗对美国偏头痛症状和医疗资源利用真实世界影响的分析
Peter McAllister,Lois Lamerato,Lynda J Krasenbaum et al.
Peter McAllister et al.
Background: Fremanezumab, a fully humanized monoclonal antibody (IgG2Δa) that selectively targets calcitonin gene-related peptide (CGRP), is approved for migraine prevention in adults. Real-world data on the effectivenes...
Observational Study
The journal of headache and pain. 2021 Dec 20;22(1):156. DOI:10.1186/s10194-021-01358-9 2021
Discontinuing monoclonal antibodies targeting CGRP pathway after one-year treatment: an observational longitudinal cohort study [0.03%]
靶向CGRP途径的单克隆抗体治疗一年后停止用药：观察性纵向队列研究
Fabrizio Vernieri,Nicoletta Brunelli,Roberta Messina et al.
Fabrizio Vernieri et al.
Background: Monoclonal antibodies anti-calcitonin gene-related peptide (mAbs anti-CGRP) pathway are effective and safe on migraine prevention. However, some drug agencies limited these treatments to one year due to their ...
Observational Study
The journal of headache and pain. 2021 Dec 18;22(1):154. DOI:10.1186/s10194-021-01363-y 2021
The relationship between headache-attributed disability and lost productivity: 2. Empirical evidence from population-based studies in nine disparate countries [0.03%]
基于人群的九个不同国家的研究关于头痛致残与生产力损失之间的关系：第二部分：实证证据
Hallie Thomas,Simple Futarmal Kothari,Andreas Husøy et al.
Hallie Thomas et al.
Background: Headache disorders are disabling, with major consequences for productivity, yet the literature is silent on the relationship between headache-attributed disability and lost productivity, often erroneously rega...
Impact of age and sex on the efficacy of fremanezumab in patients with difficult-to-treat migraine: results of the randomized, placebo-controlled, phase 3b FOCUS study [0.03%]
Fremanezumab治疗难治性偏头痛疗效与性别和年龄的关系：随机双盲安慰剂对照Ⅲb期FOCUS研究
Antoinette MaassenVanDenBrink,Gisela M Terwindt,Joshua M Cohen et al.
Antoinette MaassenVanDenBrink et al.
Background: Migraine prevalence is age and sex dependent, predominating in women in early and middle adulthood; however, migraine also represents a substantial burden for men and adults of all ages. Thus, understanding th...
In search of a gold standard patient-reported outcome measure to use in the evaluation and treatment-decision making in migraine prevention. A real-world evidence study [0.03%]
寻找金标准的患者报告结局指标用于偏头痛预防的评估和治疗决策的一个真实世界证据研究
Alicia Alpuente,Victor J Gallardo,Edoardo Caronna et al.
Alicia Alpuente et al.
Background: Patient-Reported Outcomes (PROs) have been developed to numerically quantify disability, impact and quality of life. They have been widely used in migraine clinical trials. However, we still do not know which ...
Increase in ACC GABA+ levels correlate with decrease in migraine frequency, intensity and disability over time [0.03%]
ACC中GABA+水平的升高与 migraine的频率、强度和残疾程度随时间降低有关
Aimie L Peek,Andrew M Leaver,Sheryl Foster et al.
Aimie L Peek et al.
Background: An imbalance between inhibitory and excitatory neurometabolites has been implicated in chronic pain. Prior work identified elevated levels of Gamma-aminobutyric acid + macromolecules ("GABA+") using magnetic r...
Altered brain functional network dynamics in classic trigeminal neuralgia: a resting-state functional magnetic resonance imaging study [0.03%]
经典三叉神经痛患者静息态脑功能网络动态改变的功能磁共振成像研究
Pengfei Zhang,Yanli Jiang,Guangyao Liu et al.
Pengfei Zhang et al.
Background: Accumulating studies have indicated a wide range of brain alterations with respect to the structure and function of classic trigeminal neuralgia (CTN). Given the dynamic nature of pain experience, the explorat...
Preventive treatment with CGRP monoclonal antibodies restores brain stem habituation deficits and excitability to painful stimuli in migraine: results from a prospective case-control study [0.03%]
针对偏头痛患者开展的一项前瞻性病例对照研究结果显示，CGRP单克隆抗体预防性治疗可修复脑干习惯化缺陷并减少对疼痛刺激的兴奋性
Anne Thiele,Lara Klehr,Sebastian Strauß et al.
Anne Thiele et al.
Background & objectives: Calcitonin gene-related peptide ligand/receptor (CGRP) antibodies effectively reduce headache frequency in migraine. It is understood that they act peripherally, which raises the question whether ...
Age- and frequency-dependent changes in dynamic contrast perception in visual snow syndrome [0.03%]
视觉雪症患者的动态对比感知变化与年龄和频率的关系
Ozan E Eren,Andreas Straube,Florian Schöberl et al.
Ozan E Eren et al.
Objective: Patients with visual snow syndrome (VSS) suffer from a debilitating continuous ("TV noise-like") visual disturbance. They report problems with vision at night and palinopsia despite normal visual acuity. The un...
Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation [0.03%]
Src家族激酶的活性对于皮层扩散性抑制和神经炎症中嘌呤能P2X7受体信号传导是必需的
Lingdi Nie,Dongqing Ma,John P Quinn et al.
Lingdi Nie et al.
Background: Purinergic P2X7 receptor plays an important role in migraine pathophysiology. Yet precise molecular mechanism underlying P2X7R signaling in migraine remains unclear. This study explores the hypothesis that P2X...