Kappa opioid receptor availability correlates with depressive symptom burden in chronic migraine: a preliminary investigation [0.03%]
κ-阿片受体可利用率与慢性偏头痛的抑郁症状负荷相关性初步研究
Dajung J Kim,Majid Saberi,Tanpreet Kaur et al.
Dajung J Kim et al.
Background: Chronic pain is frequently accompanied by affective disturbances, yet the neurobiological mechanisms linking pain perception and affective vulnerability remain poorly understood. The kappa opioid receptor (KOR...
Over 600 million people aged 18-65 will have headache tomorrow: global 1-day prevalence and recall bias from a meta-analysis of individual participant data (N = 38,512) from the general populations of 15 countries [0.03%]
明日将有超过六亿一十八至六十五岁的人出现头痛：针对来自十五个国家的三万八千五百一十二名普通人群体中单个参与者数据荟萃分析所得之全球日发病情况及回忆偏差
Andreas Kattem Husøy,Shengyuan Yu,Ruozhuo Liu et al.
Andreas Kattem Husøy et al.
Background: Our recent estimate of the global 1-year prevalence of headache among those aged 18-65 years was 65%: considerably higher than previous estimates, but based solely on high-quality epidemiological data derived ...
Shared genetic architecture between depression and migraine: a large-scale genome-wide cross-trait analysis [0.03%]
抑郁症和偏头痛的共享遗传结构：大规模组间跨性状分析
Min Zhang,Qiyin Li,Yuan Zhao et al.
Min Zhang et al.
Background: Depression and migraine are highly prevalent neuropsychiatric disorders that frequently co-occur. However, the extent to which they share genetic determinants, particularly for postpartum depression (PPD), an ...
Pharmacological and transcutaneous auricular vagal targeting of endoplasmic reticulum stress in the trigeminal ganglion alleviates migraine-like behaviors [0.03%]
靶向三叉神经节内质网应激的药理学和经皮耳迷走神经方法可缓解类似偏头痛的行为反应
Huan-Jun Lu,Meng-Xuan Huang,Yi-Fan Wang et al.
Huan-Jun Lu et al.
Background: Endoplasmic reticulum (ER) stress has emerged as a key player in the development of diverse chronic pain disorders; however, its specific contribution to migraine pathophysiology has yet to be fully elucidated...
A modified FLIT-B model of trigeminal neuralgia reveals anterior cingulate cortex involvement in anxiety-like behavior in mice [0.03%]
改良的FLIT-B三叉神经痛模型揭示了前扣带回在小鼠类似焦虑行为中的作用
Xiaoqin Lian,Taoxia Xie,Chen Chen et al.
Xiaoqin Lian et al.
Background: Trigeminal neuralgia (TN) is a debilitating orofacial pain disorder characterized by paroxysmal, lancinating pain and prominent affective comorbidities. Increasing evidence suggests that chronic TN involves ab...
Functional characterisation of dura mater αCGRP degradation fragments at vascular, immune, and CGRP receptor targets [0.03%]
脑膜中α-CGRPs的降解片段在血管、免疫和CGRPe受体靶点的功能表征
Mette N Jensen,Jens B Kristensen,Maria Castrillo et al.
Mette N Jensen et al.
Objective: Calcitonin gene related peptide (CGRP) is a central mediator in migraine and can trigger attacks in susceptible individuals. Therapies targeting CGRP or its receptor provide clinical benefit, but treatment resp...
Clinical, demographic, and lifestyle characteristics of patients with cervicogenic headache: comparison with an age- and sex-matched group of individuals with migraine [0.03%]
颈椎源性头痛患者的临床、人口统计和生活方式特征：与年龄及性别相匹配的偏头痛患者组的对比研究
Magdalena Nowaczewska,Sara Kierońska-Siwak,Marcin Straburzyński et al.
Magdalena Nowaczewska et al.
Background: Cervicogenic headache (CEH) can be frequently misdiagnosed as migraine. This study aimed to compare clinical, demographic, and lifestyle characteristics of patients with CEH and individuals with migraine. ...
Pharmacological mechanisms underlying neurovascular alterations related to resistant and refractory migraine: CGRP pathways and beyond [0.03%]
与难治性偏头痛相关的神经血管改变的药理学机制：CGRP通路等
Damiana Scuteri,Michalis Kodounis,Masahito Katsuki et al.
Damiana Scuteri et al.
Background: Migraine is the fourth leading cause of disability worldwide. It impairs patients' physical, emotional and social functioning, as well as their productivity. This is also due to poor pharmacological control of...
Methodology and baseline characteristics of the China Migraine registry (CHIME): a nationwide, multi-center, prospective cohort study of 11,814 patients [0.03%]
中国头痛专病注册登记（CHIME）研究的方法学和基线特征：一项针对11814例患者的前瞻性队列研究
Ye Ran,Zizi He,Xun Han et al.
Ye Ran et al.
Background: Migraine is the leading cause of years lived with disability (YLDs) in young and middle-aged populations globally. Despite strategic initiatives to standardize headache care in China, large-scale real-world ev...
Abnormal structural connectivity-functional connectivity coupling beyond the cortex in patients with chronic migraine [0.03%]
慢性偏头痛患者皮层下结构连接-功能连接耦合异常
Yan Li,Yixuan Hu,Chenyu Dai et al.
Yan Li et al.
Background: Studies have shown that patients with chronic migraine exhibit abnormalities in structural and functional brain networks. However, the underlying brain mechanisms that govern structural-to-functional connectiv...