Burden of tension-type headache in the Middle East and North Africa region, 1990-2019 [0.03%]
1990至2019年中部和北部非洲紧张型头痛负担
Saeid Safiri,Ali-Asghar Kolahi,Maryam Noori et al.
Saeid Safiri et al.
Introduction: Tension-type headache (TTH) is the most prevalent neurological disorder. As there is a gap in the literature regarding the disease burden attributable to TTH in the Middle East and North Africa (MENA) region...
Relative efficacy of lasmiditan versus rimegepant and ubrogepant as acute treatments for migraine: network meta-analysis findings [0.03%]
网络meta分析：激光地坦与瑞美吉泮和乌博gefran治疗急性偏头痛的相对疗效
Pepa Polavieja,Mark Belger,Shiva Kumar Venkata et al.
Pepa Polavieja et al.
Background: In the absence of head-to-head trials, comprehensive evidence comparing onset of efficacy of novel agents for acute treatment of migraine is lacking. This study aimed to explore the relative efficacy of lasmid...
P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine [0.03%]
小鼠偏头痛模型中P2X7R/NLRP3信号途径介导的细胞焦亡及神经炎症对认知功能障碍的影响
Yajuan Wang,Zhengming Shan,Lily Zhang et al.
Yajuan Wang et al.
Migraine is the second most common form of headache disorder and the second leading cause of disability worldwide. Cognitive symptoms ranked second resulting in migraine-related disability, after pain. P2X7 receptor (P2X7R) was recently sho...
The headache registry of the German Migraine and Headache Society (DMKG): baseline data of the first 1,351 patients [0.03%]
德国头痛协会(MGH)的头颈部疼痛登记数据库——第一年1351例患者的基线数据
Ruth Ruscheweyh,Theresa Klonowski,Gudrun Goßrau et al.
Ruth Ruscheweyh et al.
Background: Although good treatment options exist for many headache disorders, not all patients benefit and disability continues to be large. To design strategies for improving headache care, real-world data observing sta...
Contribution of tetrodotoxin-resistant persistent Na+ currents to the excitability of C-type dural afferent neurons in rats [0.03%]
河豚毒耐受的持续性钠电流对大鼠C型硬脑膜神经元兴奋性的作用
Michiko Nakamura,Il-Sung Jang
Michiko Nakamura
Background: Growing evidence supports the important role of persistent sodium currents (INaP) in the neuronal excitability of various central neurons. However, the role of tetrodotoxin-resistant (TTX-R) Na+ channel-mediat...
Hypoperfusion in nucleus accumbens in chronic migraine using 3D pseudo-continuous arterial spin labeling imaging MRI [0.03%]
使用三维伪连续动脉自旋标记成像MRI检测慢性偏头痛患者伏隔核灌注降低现象
Mengqi Liu,Yijie Sun,Xin Li et al.
Mengqi Liu et al.
Background: Nucleus accumbens (NAcc) played an important role in pain mediation, and presents changes of neuronal plasticity and functional connectivity. However, less is known about altered perfusion of NAcc in chronic m...
Repeated inflammatory dural stimulation-induced cephalic allodynia causes alteration of gut microbial composition in rats [0.03%]
重复的头皮神经炎症刺激诱发的大鼠头部异常疼痛导致肠道菌群组成变化
Shuai Miao,Wenjing Tang,Heng Li et al.
Shuai Miao et al.
Background: Gut microbial dysbiosis and gut-brain axis dysfunction have been implicated in the pathophysiology of migraine. However, it is unclear whether migraine-related cephalic allodynia could induce the alteration of...
A study to investigate the prevalence of headache disorders and migraine among people registered in a health insurance association in Japan [0.03%]
一项研究：调查日本健康保险协会登记人员中头痛和偏头痛的患病率
Fumihiko Sakai,Koichi Hirata,Hisaka Igarashi et al.
Fumihiko Sakai et al.
Background: Migraine is a chronic disease characterized by episodic headache attacks. No recent studies have, however been conducted on the epidemiology of migraine or the treatment landscape in Japan. This study was cond...
Galcanezumab effect on "whole pain burden" and multidimensional outcomes in migraine patients with previous unsuccessful treatments: a real-world experience [0.03%]
галканезумаб对之前治疗无效的偏头痛患者的“整体疼痛负担”和多维度结局的影响：真实世界经验
Marcello Silvestro,Alessandro Tessitore,Ilaria Orologio et al.
Marcello Silvestro et al.
Background: Clinical trials have demonstrated galcanezumab as safe and effective in migraine prevention. However, real-life data are still lacking and overlook the impact of galcanezumab on those different migraine facets...
CGRP and PACAP-38 play an important role in diagnosing pediatric migraine [0.03%]
CGRP和PACAP-38在儿科偏头痛诊断中发挥重要作用
Junhui Liu,Guan Wang,Yuan Dan et al.
Junhui Liu et al.
Background: An increasing number of studies have suggested that the important role of vasoactive peptides, such as pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) and calcitonin gene-related peptide (CGRP...