Olivia Grech,Matilde Sassani,Gisela Terwindt et al.
Olivia Grech et al.
Background: Migraine is a highly prevalent disorder with significant economical and personal burden. Despite the development of effective therapeutics, the causes which precipitate migraine attacks remain elusive. Clinica...
Exploring the neurobiology of the premonitory phase of migraine preclinically - a role for hypothalamic kappa opioid receptors? [0.03%]
从临床前的角度探索偏头痛先兆期的神经生物学机制-下丘脑κ型阿片受体的作用？
Caroline M Kopruszinski,Robson Vizin,Moe Watanabe et al.
Caroline M Kopruszinski et al.
Background: The migraine premonitory phase is characterized in part by increased thirst, urination and yawning. Imaging studies show that the hypothalamus is activated in the premonitory phase. Stress is a well know migra...
Synaptic alterations in visual cortex reshape contrast-dependent gamma oscillations and inhibition-excitation ratio in a genetic mouse model of migraine [0.03%]
基于遗传性偏头痛小鼠模型的视觉皮层突触改变重塑了依赖对比度的gamma振荡和抑制/兴奋比值
Nicolò Meneghetti,Chiara Cerri,Eleonora Vannini et al.
Nicolò Meneghetti et al.
Background: Migraine affects a significant fraction of the world population, yet its etiology is not completely understood. In vitro results highlighted thalamocortical and intra-cortical glutamatergic synaptic gain-of-fu...
Development and validation of a novel model for characterizing migraine outcomes within real-world data [0.03%]
用于真实世界数据中偏头痛结果特征的新型模型的开发与验证
Nada A Hindiyeh,Daniel Riskin,Kimberly Alexander et al.
Nada A Hindiyeh et al.
Background: In disease areas with 'soft' outcomes (i.e., the subjective aspects of a medical condition or its management) such as migraine or depression, extraction and validation of real-world evidence (RWE) from electro...
Does MIDAS reduction at 3 months predict the outcome of erenumab treatment? A real-world, open-label trial [0.03%]
三个月时进行MIDAS减量能否预测erasnumab治疗的效果？一项真实世界、开放标签试验
Roberto De Icco,Gloria Vaghi,Marta Allena et al.
Roberto De Icco et al.
Background: In Italy, monoclonal antibodies targeting the CGRP pathway are subsidized for the preventive treatment of high frequency and chronic migraine (CM) in patients with a MIgraine Disability ASsessment (MIDAS) scor...
A systematic review of economic evaluations of pharmacological treatments for adults with chronic migraine [0.03%]
成人慢性偏头痛药物治疗的经济学评价系统回顾
Saval Khanal,Martin Underwood,Seyran Naghdi et al.
Saval Khanal et al.
Background and aims: Chronic migraine is a common neurovascular brain disorder with substantial economic costs. We performed a systematic review to identify economic evaluations of pharmacological treatments for adults wi...
Preventive treatment can reverse cognitive impairment in chronic migraine [0.03%]
预防性治疗可逆转慢性偏头痛患者的认知障碍
Cristina González-Mingot,Anna Gil-Sánchez,Marc Canudes-Solans et al.
Cristina González-Mingot et al.
Objective: To study the impact of chronic migraine (CM) on the cognition and quality of life (QoL) of patients in the interictal period, and to analyse the degree of reversibility of any observed alterations following the...
Serum CGRP in migraine patients using erenumab as preventive treatment [0.03%]
在预防性使用依那莫单抗的偏头痛患者中检测血清CGRP水平
Simone de Vries Lentsch,Ingrid M Garrelds,A H Jan Danser et al.
Simone de Vries Lentsch et al.
Aim: Serum levels of Calcitonin Gene-Related Peptide (CGRP)-like immunoreactivity (CGRP-LI) in migraine patients before and after starting treatment with erenumab were measured to evaluate the association with clinical tr...
Functional connectivity and structural changes of thalamic subregions in episodic migraine [0.03%]
发作性偏头痛的丘脑亚区的功能连接和结构变化
Ying Yang,Huang Xu,Ziru Deng et al.
Ying Yang et al.
Background: The thalamus plays a crucial role in transmitting nociceptive information to various cortical regions involving migraine-related allodynia and photophobia. Abnormal structural and functional alterations relate...
The prevalence of primary headache disorders in children and adolescents in Zambia: a schools-based study [0.03%]
赞比亚学龄儿童和青少年原发性头痛的患病率：基于学校的调查研究
Nfwama Kawatu,Somwe Wa Somwe,Ornella Ciccone et al.
Nfwama Kawatu et al.
Background: The Global Campaign against Headache collects data from children (6-11 years) and adolescents (12-17) to inform health and education policies and contribute to the Global Burden of Disease (GBD) study. This su...