CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine [0.03%]
中枢杏仁核中PKC-δ阳性神经元的CGRP依赖性敏化介导慢性偏头痛
Tse-Ming Chou,Zhung-Fu Lee,Shuu-Jiun Wang et al.
Tse-Ming Chou et al.
Background: To investigate specific brain regions and neural circuits that are responsible for migraine chronification. Methods: We est...
Cerebral perfusion variance in new daily persistent headache and chronic migraine: an arterial spin-labeled MR imaging study [0.03%]
新发每日持续性头痛和慢性偏头痛的脑灌注差异：一项动脉自旋标记磁共振成像研究
Xiaoyan Bai,Wei Wang,Xueyan Zhang et al.
Xiaoyan Bai et al.
Background and purpose: New daily persistent headache (NDPH) and chronic migraine (CM) are two different types of headaches that might involve vascular dysregulation. There is still a lack of clarity about altered brain p...
PACAP signaling is not involved in GTN- and levcromakalim-induced hypersensitivity in mouse models of migraine [0.03%]
GTN和levcromakalim诱导的偏头痛小鼠模型中的超敏反应不涉及PACAP信号传导
Song Guo,Charlotte Ernstsen,Anders Hay-Schmidt et al.
Song Guo et al.
Background: Calcitonin gene-related peptide (CGRP) antagonizing drugs represents the most important advance in migraine therapy for decades. However, these new drugs are only effective in 50-60% of patients. Recent studie...
Effects of eptinezumab on self-reported work productivity in adults with migraine and prior preventive treatment failure in the randomized, double-blind, placebo-controlled DELIVER study [0.03%]
在随机、双盲、安慰剂对照的DELIVER研究中，Eptinezumab对之前预防性治疗失败的偏头痛成人自我报告的工作效率的影响
Piero Barbanti,Peter J Goadsby,Giorgio Lambru et al.
Piero Barbanti et al.
Background: The multinational phase 3b DELIVER trial was designed to evaluate the efficacy and safety of eptinezumab for migraine prevention in patients with prior preventive treatment failures across 17 countries. In the...
Altered functional connectivity of the right caudate nucleus in chronic migraine: a resting-state fMRI study [0.03%]
慢性偏头痛右侧尾状核功能连接发生改变的静息状态fMRI研究
Ziyu Yuan,Wei Wang,Xueyan Zhang et al.
Ziyu Yuan et al.
Background: The definitive pathogenic mechanisms underlying chronic migraine (CM) remain unclear. Mounting evidence from functional and structural magnetic resonance imaging (MRI) studies suggests that the caudate nucleus...
Expression of vasopressin and its receptors in migraine-related regions in CNS and the trigeminal system: influence of sex [0.03%]
与偏头痛相关的中枢神经系统和三叉神经系统的血管压素及其受体的表达情况：性别影响研究
Aida Maddahi,Lars Edvinsson,Karin Warfvinge
Aida Maddahi
Background: Hypothalamus is a key region in migraine attacks. In addition, women are disproportionately affected by migraine. The calcitonin gene-related peptide (CGRP) system is an important key player in migraine pathop...
Debate: Are cluster headache and migraine distinct headache disorders? [0.03%]
争论：丛集性头痛和偏头痛是完全不同的头痛类型吗？
Mohammad Al-Mahdi Al-Karagholi,Kuan-Po Peng,Anja Sofie Petersen et al.
Mohammad Al-Mahdi Al-Karagholi et al.
Cluster headache and migraine are regarded as distinct primary headaches. While cluster headache and migraine differ in multiple aspects such as gender-related and headache specific features (e.g., attack duration and frequency), both show ...
Trigeminal ganglion itself can be a viable target to manage trigeminal neuralgia [0.03%]
三叉神经节本身可以成为治疗三叉神经痛的可行靶点
Elina Kc,Jaisan Islam,Young Seok Park
Elina Kc
Excruciating trigeminal neuralgia (TN) management is very difficult and severely affects the patient's quality of life. Earlier studies have shown that the trigeminal ganglion (TG) comprises several receptors and signal molecules that are i...
Tracking the evolution of non-headache symptoms through the migraine attack [0.03%]
追踪偏头痛发作过程中非头痛症状的演变过程
Roberta Messina,Ilaria Cetta,Bruno Colombo et al.
Roberta Messina et al.
Background: The migraine attack is classically divided into the prodromal, aura, headache and postdromal phase. Previous studies have highlighted non-headache symptoms associated with migraine occurring during the prodrom...
Variability in recurrence rates with acute treatments for migraine: why recurrence is not an appropriate outcome measure [0.03%]
偏头痛急性治疗中复发率的变化性：为何复发并非适当的结果测量标准
Stewart J Tepper,Jessica Ailani,Sutapa Ray et al.
Stewart J Tepper et al.
Background: Headache recurrence is a common feature of acute therapies, whether approved or still in development, and continues to be a significant problem for both the patient and the clinician. Further complicating this...