Shared and independent roles of CGRP and PACAP in migraine pathophysiology [0.03%]
CGRP和PACAP在偏头痛病理生理中的共同作用和独立作用
Adisa Kuburas,Andrew F Russo
Adisa Kuburas
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both are vasodilatory peptides that can cause migraine-like attacks ...
Is the right way to go in between? : Rimegepant as needed provides preventive benefit. A comment on: monthly migraine days, tablet utilization, and quality of life associated with rimegepant-post hoc results from an open label safety study (BHV3000-201) [0.03%]
中路才是正道吗？：按需使用rimegepant可产生预防效果。对“基于对BHV3000-201开放标签安全性研究的事后分析，rimegepant与每月偏头痛天数、片剂利用率和生活质量相关”一文的评论
Andreas R Gantenbein,Andreas Kleinschmidt
Andreas R Gantenbein
In the study by Johnston et al., gepants were meant to be taken to treat emergent migraine. It is tempting to speculate what the effect would be if patients were instructed to take a gepant as needed (PRN) or even prior to headache onset. W...
Disease burden of migraine and tension-type headache in non-high-income East and Southeast Asia from 1990 to 2019 [0.03%]
1990至2019年非高收入东亚和东南亚地区偏头痛和肌紧张性头痛疾病负担
Rongguang Ge,Jie Chang
Rongguang Ge
Background: The world faces severe challenges from migraine and tension-type headache (TTH), which cause grave disability to patients and place a heavy burden on their caregivers. However, headaches in specific individual...
Anna K Szewczyk,Samiye Ulutas,Tülin Aktürk et al.
Anna K Szewczyk et al.
Migraine is a severe neurovascular disorder of which the pathophysiology is not yet fully understood. Besides the role of inflammatory mediators that interact with the trigeminovascular system, cyclic fluctuations in sex steroid hormones ar...
Early and sustained efficacy of fremanezumab over 24-weeks in migraine patients with multiple preventive treatment failures: the multicenter, prospective, real-life FRIEND2 study [0.03%]
一项多中心前瞻性真实世界研究：对于多种预防治疗失败的偏头痛患者，fremanezumab早期且持续有效——FRIEND2研究
Piero Barbanti,Gabriella Egeo,Cinzia Aurilia et al.
Piero Barbanti et al.
Background: To verify the long-term (24-week) efficacy, safety, and tolerability of fremanezumab in real-life patients with high-frequency episodic migraine (HFEM: ≥ 8 days/month) or chronic migraine (CM: ≥ 15 days/mont...
Multicenter Study
The journal of headache and pain. 2023 Mar 23;24(1):30. DOI:10.1186/s10194-023-01561-w 2023
A study on the correlation of the asymmetric regulation between the periaqueductal gray and the bilateral trigeminal nucleus caudalis in migraine male rats [0.03%]
关于偏头痛雄性大鼠导水管周围灰质与双侧延髓三叉神经脊核不对称调控相关性的研究
Zhijian Cao,Wenjing Yu,Luping Zhang et al.
Zhijian Cao et al.
Background: The study was designed to explore the correlation of the asymmetric regulation between periaqueductal gray (PAG) and bilateral trigeminal nucleus caudalis (TNC) in migraine rats through studying the changes of...
FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability [0.03%]
FGF-21和GDF-15在偏头痛患者中升高并与偏头痛相关伤残严重程度有关
Jiahui He,Mengting Zhou,Fanglin Zhao et al.
Jiahui He et al.
Background: Migraine is a prevalent disorder with significant socioeconomic impact. The impairment of metabolic homeostasis in migraine warrants further investigation. Changes in serum levels of Fibroblast-growth-factor 2...
A novel score to estimate thrombus burden and predict intracranial hypertension in cerebral venous sinus thrombosis [0.03%]
一种估计脑静脉窦血栓形成中血栓负担和预测颅内高压的新评分系统
Zhongao Wang,Chaitu Dandu,Yibing Guo et al.
Zhongao Wang et al.
Background: Current methods to evaluate the severity of cerebral venous sinus thrombosis (CVST) lack patient-specific indexes. Herein, a novel scoring method was investigated to estimate the thrombus burden and the intrac...
Galcanezumab effects on incidence of headache after occurrence of triggers, premonitory symptoms, and aura in responders, non-responders, super-responders, and super non-responders [0.03%]
对于响应者、非响应者、超级响应者和超级非响应者的触发因素、先兆症状和前驱症状后头痛发作的影响
Sait Ashina,Agustin Melo-Carrillo,Ajayi Toluwanimi et al.
Sait Ashina et al.
Background: The goal of this observational, open-label, cohort study was to determine whether prophylactic migraine treatment with galcanezumab, a peripherally acting drug, alters the incidence of premonitory symptoms, an...
Observational Study
The journal of headache and pain. 2023 Mar 16;24(1):26. DOI:10.1186/s10194-023-01560-x 2023
Cross-sectional, hospital-based analysis of headache types using ICHD-3 criteria in the Middle East, Asia, and Africa: the Head-MENAA study [0.03%]
基于横断面的医院头痛类型分析：在中东、亚洲和非洲使用ICHD-3标准进行Head-MENAA研究
H Genc,B Baykan,H Bolay et al.
H Genc et al.
Background: Headaches are frequent neurological disorders that are yet to be unveiled and treated comprehensively worldwide. Bearing in mind that the distribution of headache subtypes in neurology clinics (NC) is essentia...
Multicenter Study
The journal of headache and pain. 2023 Mar 13;24(1):24. DOI:10.1186/s10194-023-01555-8 2023