Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model [0.03%]
CB1受体激活通过调节HCN2-pNR2B信号通路缓解慢性偏头痛模型的大脑敏化现象
Xiaoxu Zeng,Jia Mai,Hongjian Xie et al.
Xiaoxu Zeng et al.
Background: Central sensitization has been widely accepted as an underlying pathophysiological mechanism of chronic migraine (CM), activation of cannabinoid type-1 receptor (CB1R) exerts antinociceptive effects by relievi...
Neuroanatomical restoration of salience network links reduced headache impact to cognitive function improvement in mild traumatic brain injury with posttraumatic headache [0.03%]
头伤后头痛的脑损伤患者中取代表征网络连接恢复可减轻头痛影响并改善认知功能
Hui Xu,Cheng Xu,Pengpeng Gu et al.
Hui Xu et al.
Background: Neuroanatomical alterations have been associated with cognitive deficits in mild traumatic brain injury (MTBI). However, most studies have focused on the abnormal gray matter volume in widespread brain regions...
PAR2 activation in the dura causes acute behavioral responses and priming to glyceryl trinitrate in a mouse migraine model [0.03%]
活化终末疼痛感受器触发急性和延迟的偏头痛样症状小鼠模型
Bianca N Mason,Shayne N Hassler,Kathryn DeFea et al.
Bianca N Mason et al.
Background: Migraine is a severely debilitating disorder that affects millions of people worldwide. Studies have indicated that activation of protease-activated receptor-2 (PAR2) in the dura mater causes headache response...
Periaqueductal gray matter echogenicity as a marker of migraine chronification: a case control study [0.03%]
中脑导水管周围灰质回声强度作为偏头痛慢性化的标志：一项病例对照研究
Dolores Vilas,Sara Rubio,Mireia Gea et al.
Dolores Vilas et al.
Background: Migraine is one of the most prevalent and disabling medical diseases in the world. The periaqueductal gray matter and the red nucleus play an important role in its pathogenesis. Our aim was to evaluate the ech...
Migraine symptoms, healthcare resources utilization and disease burden in a large Polish migraine cohort : Results from 'Migraine in Poland'-a nationwide cross-sectional survey [0.03%]
波兰全国性大规模偏头痛患者的偏头痛症状、医疗资源利用和疾病负担：“波兰偏头痛”横断面调查结果摘要
Marta Waliszewska-Prosół,Marcin Straburzyński,Ewa K Czapińska-Ciepiela et al.
Marta Waliszewska-Prosół et al.
Background: The Migraine in Poland study is the first large scale nationwide cross-sectional online survey of symptoms, approaches to management, treatment patterns, quality of life, and sociodemographic characteristics o...
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention-part 1: amitriptyline [0.03%]
欧洲头痛协会（EHF）对偏头痛预防的口服药物重新评估及荟萃分析第一部分：阿米替林
Christian Lampl,Jan Versijpt,Faisal Mohammad Amin et al.
Christian Lampl et al.
Objective: The aim of this paper is to critically re-appraise the published trials assessing amitriptyline for migraine prophylaxis. Methods: ...
Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain [0.03%]
potent双MAGL/FAAH抑制剂AKU-005通过作用于内源大麻素系统来减少与偏头痛疼痛相关的脑膜痛觉过敏
Adriana Della Pietra,Georgii Krivoshein,Konstantin Ivanov et al.
Adriana Della Pietra et al.
Background: Engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids (endoCBs) 2-arachidonoylglycerol (2-AG) and anandamide...
Headache impact and socioeconomic status: findings from a study of the German Migraine and Headache Society (DMKG) [0.03%]
头痛影响及经济状况：德国头痛和偏头痛协会的研究结果
Britta Müller,Charly Gaul,Olaf Reis et al.
Britta Müller et al.
Backgound: Headache disorders are not only among the most prevalent, they are also among the most disabling disorders worldwide. This paper investigates the association between headache impact on daily life and the socioe...
Bernadett Tuka,Tamás Körtési,Nikolett Nánási et al.
Bernadett Tuka et al.
Background: The glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites derived from catabolism of tryptophan (Trp) have significant involvement n...
Cytokines in primary headache disorders: a systematic review and meta-analysis [0.03%]
原发性头痛疾病细胞因子的系统评价和荟萃分析
Abdu Kisekka Musubire,Sanjay Cheema,Jason C Ray et al.
Abdu Kisekka Musubire et al.
Background: The role of inflammation and cytokines in the pathophysiology of primary headache disorders is uncertain. We performed a systematic review and meta-analysis to synthesise the results of studies comparing perip...