Early life stress induces brain-wide electrical network predisposition to migraine [0.03%]
早期压力通过诱导广泛的脑电网络倾向性而成为偏头痛的发病因素
Micah Johnson,Maureen Eberle,Ian Hultman et al.
Micah Johnson et al.
Background: Migraine is a disorder of severe, recurrent headaches and debilitating sensory, cognitive and affective symptoms, often triggered by stress. Early life stress in childhood has been shown to increase the likeli...
CD4+T cells mediate systemic and local immune changes and pain symptoms in the rat model of temporomandibular disorders related pain [0.03%]
CD4⁺T细胞介导的大鼠颞下颌紊乱相关疼痛模型中的全身及局部免疫变化和痛觉症状
Jianquan He,Yuzhuo Hei,Lin Li et al.
Jianquan He et al.
Background and purpose: Immune cells involved in pain has received increasing attention, but the available literature on the role of T cells in temporomandibular disorders (TMD) related pain is limited. Our previous study...
Consistency of response to rimegepant for the acute treatment of migraine among real-world users - findings from the prospective observational CONFIDENCE study [0.03%]
REALITY研究：rimegepant治疗偏头痛急性发作疗效的持久性：CONFIDENCE研究结果
Richard B Lipton,Lucy Abraham,Alexandre Urani et al.
Richard B Lipton et al.
Background: Real-world data on the effectiveness of rimegepant for the acute treatment of migraine is limited, particularly regarding consistency of response over multiple attacks. ...
Oscillatory edge connectivity in pain-related regions supports machine learning identification of migraine [0.03%]
与疼痛相关区域的振荡边缘连接性支持机器学习识别偏头痛
Fu-Jung Hsiao,Kuan-Lin Lai,Wei-Ta Chen et al.
Fu-Jung Hsiao et al.
Background: Objective and interpretable brain signatures for migraine diagnosis and phenotyping remain limited. Edge-centric connectivity treats interregional connections as primary analytical units and captures higher-or...
Blood-brain barrier integrity and brain entropy in reversible cerebral vasoconstriction syndrome [0.03%]
可逆性脑血管收缩综合征患者血脑屏障完整性和脑熵的研究
Chia-Hung Wu,Tun-Wei Hsu,Yu-Hsiang Ling et al.
Chia-Hung Wu et al.
Background: Elucidating functional brain dynamics under different blood-brain barrier (BBB) permeabilities may resolve the enigmatic pathophysiology of reversible cerebral vasoconstriction (RCVS); however, relevant invest...
Integrative multi-omics analysis identifies endocrine-disrupting chemical-related molecular mechanisms in migraine [0.03%]
整合多组学分析识别出与偏头痛相关的内分泌干扰化学物质相关分子机制
Yinfan Ren,Ziqi Xu,Zifei Xu et al.
Yinfan Ren et al.
Background: Migraine is a highly prevalent, heritable neurological disorder with a marked female predominance, indicating substantial hormonal contributions to disease pathophysiology. Endocrine-disrupting chemicals (EDCs...
Sex-dependent central amygdala physiology after supradural CGRP exposure is associated with migraine-like behaviors [0.03%]
外源性CGRP致敏诱导雌雄小鼠发生偏头痛样行为的差异及中央杏仁核神经元活动的变化
Nico Antenucci,Sambantham Shanmugam,Mariacristina Mazzitelli et al.
Nico Antenucci et al.
Background: Calcitonin gene-related peptide (CGRP) is a key mediator of migraine, but the mechanisms through which meningeal CGRP engages central circuits involved in the sensory and affective dimensions of migraine remai...
Central sensitization, work-related stress, and musculoskeletal pain symptoms in desk-based workers with and without migraine: a cross-sectional study [0.03%]
中枢敏化、与工作相关的压力以及桌面办公的偏头痛患者和非偏头痛患者的肌肉骨骼疼痛症状：一项横断面研究
Dilara Onan,Pelin Yenilmez Yeşildaş,Merve Ceren Akgör et al.
Dilara Onan et al.
Background: Migraine can impair productivity, work performance, and daily functioning in working-age adults. While higher Central Sensitization Inventory (CSI) scores have been observed in migraine chronicity, work-relate...
Transcriptional correlates of structure-function coupling plasticity in trigeminal neuralgia: unveiling the synaptic and metabolic associations [0.03%]
三叉神经痛结构功能耦合可塑性的转录相关性：揭示突触和代谢关联
Jian Zhang,Xujing Nie,Shuyue Fu et al.
Jian Zhang et al.
Background: Trigeminal neuralgia (TN) is characterized by severe facial pain, transitioning from peripheral vascular compression to central sensitization. However, the core central pathophysiological mechanisms-particular...
A glutamatergic ventrolateral periaqueductal gray-lateral habenula pathway is associated with depression-like behavioral measures in young adult male mice with trigeminal neuropathic pain [0.03%]
小鼠三叉神经病理性疼痛抑郁样行为与谷氨酸能室导水管周围灰质侧缰核通路有关
Lulu Zhang,Yizhen Yao,Chengmao Zhou et al.
Lulu Zhang et al.
Background: Depression is a clinically important comorbidity of trigeminal pain disorders, including trigeminal neuralgia, yet the neural circuits linking persistent trigeminal nerve injury to negative affect remain incom...