In patients' words: natural language processing of reports from patients experiencing orofacial pain and dysfunction [0.03%]
患者的言语：自然语言处理患者经受口腔面部疼痛和功能障碍的报告
Dominik A Ettlin,Markus Wolf,Nikola Biller-Andorno et al.
Dominik A Ettlin et al.
Background: Provision of value-based, patient-centered care requires careful appraisal of patients’ symptoms. Understanding subjective experiences, needs, and feelings is crucial for shared decision-making, especially wh...
Calcitonin gene-related peptide monoclonal antibody treatment for new daily persistent headache [0.03%]
新发每日持续性头痛的降钙素基因相关肽单克隆抗体治疗
Sanjay Cheema,Khadija Rerhou Rantell,Rachel Pickering et al.
Sanjay Cheema et al.
Background: New daily persistent headache (NDPH) is a rare headache disorder that often resembles chronic migraine (CM) phenotypically, but unlike CM is daily from onset. Several calcitonin gene-related peptide monoclonal...
Observational Study
The journal of headache and pain. 2025 Jul 28;26(1):170. DOI:10.1186/s10194-025-02111-2 2025
Headache diagnosis in children and adolescents: validation of the Italian version of the HARDSHIP questionnaire [0.03%]
儿童和青少年头痛诊断：意大利版HARDSHIP问卷的验证研究
Agnese Onofri,Raffaele Ornello,Chiara Rosignoli et al.
Agnese Onofri et al.
Background: Headache disorders are common in children and adolescents, significantly affecting quality of life and academic performance. Despite their high prevalence, they remain underdiagnosed and undertreated. The Chil...
The DRN-VLO pathway via distinct 5-HT synaptic mechanisms modulates neuropathic pain-induced depressive-like behaviors in mice [0.03%]
小鼠慢性神经痛抑郁样行为的调控涉及DRN-VLO通路依赖和非依赖5-HT突触机制
Hai-Yan Sheng,Wei-Zhen Liu,Yan-Kai Liu et al.
Hai-Yan Sheng et al.
Background: The neuronal activities within the dorsal raphe nucleus (DRN) and the ventrolateral orbital cortex (VLO) are strongly implicated in the development of depression, a condition comorbid with chronic pain. The go...
Psychological transdiagnostic factors and migraine characteristics as predictors of migraine-related disability [0.03%]
心理共病因素和偏头痛特征作为偏头痛相关残疾的预测指标
Janosch Fox,Charly Gaul,Julia Ohse et al.
Janosch Fox et al.
Background: Migraine is a prevalent primary headache disorder that significantly impairs daily life. Research on factors contributing to migraine-related disability remains limited, particularly from a biopsychosocial per...
Randomized Controlled Trial
The journal of headache and pain. 2025 Jul 23;26(1):167. DOI:10.1186/s10194-025-02101-4 2025
Botulinum toxin type A inhibits microglia pyroptosis by suppressing Cblb-mediated degradation of Pdlim1 to attenuate neuropathic pain [0.03%]
肉毒杆菌毒素A通过抑制Cblb介导的Pdlim1降解来抑制小胶质细胞焦亡从而缓解神经病理性疼痛
Sheng Tian,Lanxiang Wu,Heqing Zheng et al.
Sheng Tian et al.
Background: Microglia pyroptosis, a newly identified form of inflammatory cell death, is involved in the development of neuropathic pain (NP). Botulinum toxin type A (BTX-A) has been shown to be effective in relieving NP,...
The efficacy and mechanisms of low-intensity transcranial ultrasound stimulation on pain: a systematic review of human and animal studies [0.03%]
低强度经颅超声刺激的镇痛效果及机制：人类和动物研究的系统综述
Hao-Ran Xu,Yiu-Liang Yi,Chuan Xue et al.
Hao-Ran Xu et al.
Background: Low-intensity transcranial ultrasound stimulation (LITUS) is an emerging non-invasive neuromodulation technique for pain treatment, with the unique ability to modulate deep brain nuclei associated with pain. T...
Li-Ling Hope Pan,Yu-Hsiang Ling,Shuu-Jiun Wang et al.
Li-Ling Hope Pan et al.
Background and aim: Tension-type headache is the most prevalent primary headache disorder. While the episodic subtype is more common, chronic tension-type headache significantly impacts health-related quality of life and ...
Chisato Iba,Miyuki Unekawa,Keiko Ihara et al.
Chisato Iba et al.
Background: Antiseizure medications are often used as preventive treatment of migraine in appropriate cases; however, the efficacy of lacosamide (LCM), a sodium channel blocker, in preventing migraine attacks remains uncl...
Structural alterations in occipital cortices in trigeminal neuralgia: a voxel- and surface-based morphometric MRI study [0.03%]
三叉神经痛患者枕区皮层结构异常的体素和基于表面积的形态测量学研究
Francesca Caramia,Antonio Di Renzo,Marco Fiorelli et al.
Francesca Caramia et al.
Background: To investigate gray matter structural alterations in patients with primary trigeminal neuralgia (TN) using voxel-based and surface-based morphometry, and to explore potential associations with clinical and neu...