A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for migraine [0.03%]
横跨组织的转录组关联研究揭示了偏头痛的新易感基因
Jianxiong Gui,Xiaoyue Yang,Chen Tan et al.
Jianxiong Gui et al.
Background: Migraine is a common neurological disorder with a strong genetic component. Despite the identification of over 100 loci associated with migraine susceptibility through genome-wide association studies (GWAS), t...
Genetic evidence for the causal relationships between migraine, dementia, and longitudinal brain atrophy [0.03%]
遗传学证据表明偏头痛、痴呆和脑萎缩之间的因果关系
Lei Zhao,Yilan Tang,Yiheng Tu et al.
Lei Zhao et al.
Background: Migraine is a neurological disease with a significant genetic component and is characterized by recurrent and prolonged episodes of headache. Previous epidemiological studies have reported a higher risk of dem...
Plasma calcitonin gene-related peptide levels in idiopathic intracranial hypertension: an exploratory study [0.03%]
特发性颅内高压患者血浆降钙素基因相关肽水平的探索性研究
Nik Krajnc,Florian Frank,Stefan Macher et al.
Nik Krajnc et al.
Background: Idiopathic intracranial hypertension (IIH) is a debilitating condition characterized by increased intracranial pressure often presenting with chronic migraine-like headache. Calcitonin gene-related peptide (CG...
GBD2021: headache disorders and global lost health - a focus on children, and a view forward [0.03%]
GBD 2021 儿童偏头痛概览及未来展望：全球失衡健康状况下的儿童头痛障碍
Timothy J Steiner,Andreas Husøy,Lars Jacob Stovner
Timothy J Steiner
Therapeutic patterns and migraine disease burden in switchers of CGRP-targeted monoclonal antibodies - insights from the German NeuroTransData registry [0.03%]
德国神经元转录数据登记处CGRP靶向单克隆抗体转换者中的治疗模式和偏头痛疾病负担——来自德国神经元传输数据登记处的见解
Ja Bin Hong,Heike Israel-Willner,Andreas Peikert et al.
Ja Bin Hong et al.
Background: Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway have shown good efficacy in migraine prophylaxis. However, a subset of patients does not respond to the first mAb treat...
Helin Gosalia,David Moreno-Ajona,Peter J Goadsby
Helin Gosalia
Medication-overuse headache (MOH), which potentially involves 1-2% of the population, is defined as a headache, on ≥ 15 days a month affected, along with overuse of one or other acute attack medications. MOH presents with significant chall...
Brain structural and functional abnormalities associated with acute post-traumatic headache: iron deposition and functional connectivity [0.03%]
急性创伤性头痛相关的脑结构和功能异常：铁沉积与功能连接性
Simona Nikolova,Catherine Chong,Jing Li et al.
Simona Nikolova et al.
Background: The purpose of this study was to interrogate brain iron accumulation in participants with acute post-traumatic headache (PTH) due to mild traumatic brain injury (mTBI), and to determine if functional connectiv...
PACAP38/mast-cell-specific receptor axis mediates repetitive stress-induced headache in mice [0.03%]
促肾上腺皮质激素释放肽38/肥大细胞特异性受体轴介导应激性头痛
Hyeonwi Son,Yan Zhang,John Shannonhouse et al.
Hyeonwi Son et al.
Background: Pain, an evolutionarily conserved warning system, lets us recognize threats and motivates us to adapt to those threats. Headache pain from migraine affects approximately 15% of the global population. However, ...
The burdens attributable to primary headache disorders in children and adolescents in Iran: estimates from a schools-based study [0.03%]
基于学校的估计：伊朗儿童和青少年原发性头痛障碍的负担
Mansoureh Togha,Pegah Rafiee,Faraidoon Haghdoost et al.
Mansoureh Togha et al.
Background: We recently found headache disorders to be highly prevalent among children (aged 6-11 years) and adolescents (aged 12-17) in Iran (gender- and age-adjusted 1-year prevalences: migraine 25.2%, tension-type head...
MERTK in the rat trigeminal system: a potential novel target for cluster headache? [0.03%]
大鼠三叉神经系统的MERTK：群集性头痛的潜在新靶点？
Jacob C A Edvinsson,Caroline Ran,Felicia Jennysdotter Olofsgård et al.
Jacob C A Edvinsson et al.
The trigeminal system is key to the pathophysiology of migraine and cluster headache, two primary headache disorders that share many features. Recently, MER proto-oncogene tyrosine kinase (MERTK), a cell surface receptor, was strongly assoc...